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Protein

Arabinose import ATP-binding protein AraG

Gene

araG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system (Probable).2 Publications

Catalytic activityi

ATP + H2O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In).UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 47ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processSugar transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:ARAG-MONOMER
MetaCyc:ARAG-MONOMER

Protein family/group databases

TCDBi3.A.1.2.2 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Arabinose import ATP-binding protein AraGUniRule annotation (EC:3.6.3.17UniRule annotation)
Gene namesi
Name:araGUniRule annotation
Ordered Locus Names:b1900, JW1888
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10058 araG

Subcellular locationi

  • Cell inner membrane UniRule annotation1 Publication; Peripheral membrane protein UniRule annotation1 Publication

GO - Cellular componenti

  • cytosol Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000919361 – 504Arabinose import ATP-binding protein AraGAdd BLAST504

Proteomic databases

PaxDbiP0AAF3
PRIDEiP0AAF3

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (AraG), two transmembrane proteins (AraH) and a solute-binding protein (AraF).UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
metQP286353EBI-559586,EBI-1114713

Protein-protein interaction databases

BioGridi4261851, 4 interactors
DIPiDIP-48055N
IntActiP0AAF3, 7 interactors
STRINGi316385.ECDH10B_2040

Structurei

3D structure databases

ProteinModelPortaliP0AAF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 243ABC transporter 1UniRule annotationAdd BLAST236
Domaini256 – 499ABC transporter 2UniRule annotationAdd BLAST244

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Arabinose importer (TC 3.A.1.2.2) family. [View classification]UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105C2J Bacteria
COG1129 LUCA
InParanoidiP0AAF3
KOiK10539
OMAiDEHRVLD
PhylomeDBiP0AAF3

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR017917 ABC_transptr_Ara_ATP-bd_AraG
IPR027417 P-loop_NTPase
PANTHERiPTHR43790:SF6 PTHR43790:SF6, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits
PS51268 ARAG, 1 hit

Sequencei

Sequence statusi: Complete.

P0AAF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQSTPYLSF RGIGKTFPGV KALTDISFDC YAGQVHALMG ENGAGKSTLL
60 70 80 90 100
KILSGNYAPT TGSVVINGQE MSFSDTTAAL NAGVAIIYQE LHLVPEMTVA
110 120 130 140 150
ENIYLGQLPH KGGIVNRSLL NYEAGLQLKH LGMDIDPDTP LKYLSIGQWQ
160 170 180 190 200
MVEIAKALAR NAKIIAFDEP TSSLSAREID NLFRVIRELR KEGRVILYVS
210 220 230 240 250
HRMEEIFALS DAITVFKDGR YVKTFTDMQQ VDHDALVQAM VGRDIGDIYG
260 270 280 290 300
WQPRSYGEER LRLDAVKAPG VRTPISLAVR SGEIVGLFGL VGAGRSELMK
310 320 330 340 350
GMFGGTQITA GQVYIDQQPI DIRKPSHAIA AGMMLCPEDR KAEGIIPVHS
360 370 380 390 400
VRDNINISAR RKHVLGGCVI NNGWEENNAD HHIRSLNIKT PGAEQLIMNL
410 420 430 440 450
SGGNQQKAIL GRWLSEEMKV ILLDEPTRGI DVGAKHEIYN VIYALAAQGV
460 470 480 490 500
AVLFASSDLP EVLGVADRIV VMREGEIAGE LLHEQADERQ ALSLAMPKVS

QAVA
Length:504
Mass (Da):55,018
Last modified:August 1, 1988 - v1
Checksum:i23B401BCF34CFA3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06091 Genomic DNA Translation: CAA29477.1
U00096 Genomic DNA Translation: AAC74970.1
AP009048 Genomic DNA Translation: BAA15720.1
PIRiS01074
RefSeqiNP_416413.1, NC_000913.3
WP_001187819.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74970; AAC74970; b1900
BAA15720; BAA15720; BAA15720
GeneIDi946408
KEGGiecj:JW1888
eco:b1900
PATRICifig|1411691.4.peg.350

Similar proteinsi

Entry informationi

Entry nameiARAG_ECOLI
AccessioniPrimary (citable) accession number: P0AAF3
Secondary accession number(s): P08531
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: April 25, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health