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Protein

Arabinose import ATP-binding protein AraG

Gene

araG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system (Probable).2 Publications

Catalytic activityi

ATP + H2O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In).UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 478ATPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Sugar transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:ARAG-MONOMER.
ECOL316407:JW1888-MONOMER.
MetaCyc:ARAG-MONOMER.

Protein family/group databases

TCDBi3.A.1.2.2. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Arabinose import ATP-binding protein AraGUniRule annotation (EC:3.6.3.17UniRule annotation)
Gene namesi
Name:araGUniRule annotation
Ordered Locus Names:b1900, JW1888
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10058. araG.

Subcellular locationi

  • Cell inner membrane UniRule annotation1 Publication; Peripheral membrane protein UniRule annotation1 Publication

GO - Cellular componenti

  • cytosol Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Arabinose import ATP-binding protein AraGPRO_0000091936Add
BLAST

Proteomic databases

PaxDbiP0AAF3.
PRIDEiP0AAF3.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (AraG), two transmembrane proteins (AraH) and a solute-binding protein (AraF).UniRule annotation

Protein-protein interaction databases

BioGridi4261851. 3 interactions.
DIPiDIP-48055N.
IntActiP0AAF3. 7 interactions.
MINTiMINT-1305954.
STRINGi511145.b1900.

Structurei

3D structure databases

ProteinModelPortaliP0AAF3.
SMRiP0AAF3. Positions 8-502.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 243236ABC transporter 1UniRule annotationAdd
BLAST
Domaini256 – 499244ABC transporter 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Arabinose importer (TC 3.A.1.2.2) family. [View classification]UniRule annotation
Contains 2 ABC transporter domains.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105C2J. Bacteria.
COG1129. LUCA.
InParanoidiP0AAF3.
KOiK10539.
OMAiAKHEIYH.
PhylomeDBiP0AAF3.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
PS51268. ARAG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AAF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQSTPYLSF RGIGKTFPGV KALTDISFDC YAGQVHALMG ENGAGKSTLL
60 70 80 90 100
KILSGNYAPT TGSVVINGQE MSFSDTTAAL NAGVAIIYQE LHLVPEMTVA
110 120 130 140 150
ENIYLGQLPH KGGIVNRSLL NYEAGLQLKH LGMDIDPDTP LKYLSIGQWQ
160 170 180 190 200
MVEIAKALAR NAKIIAFDEP TSSLSAREID NLFRVIRELR KEGRVILYVS
210 220 230 240 250
HRMEEIFALS DAITVFKDGR YVKTFTDMQQ VDHDALVQAM VGRDIGDIYG
260 270 280 290 300
WQPRSYGEER LRLDAVKAPG VRTPISLAVR SGEIVGLFGL VGAGRSELMK
310 320 330 340 350
GMFGGTQITA GQVYIDQQPI DIRKPSHAIA AGMMLCPEDR KAEGIIPVHS
360 370 380 390 400
VRDNINISAR RKHVLGGCVI NNGWEENNAD HHIRSLNIKT PGAEQLIMNL
410 420 430 440 450
SGGNQQKAIL GRWLSEEMKV ILLDEPTRGI DVGAKHEIYN VIYALAAQGV
460 470 480 490 500
AVLFASSDLP EVLGVADRIV VMREGEIAGE LLHEQADERQ ALSLAMPKVS

QAVA
Length:504
Mass (Da):55,018
Last modified:August 1, 1988 - v1
Checksum:i23B401BCF34CFA3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06091 Genomic DNA. Translation: CAA29477.1.
U00096 Genomic DNA. Translation: AAC74970.1.
AP009048 Genomic DNA. Translation: BAA15720.1.
PIRiS01074.
RefSeqiNP_416413.1. NC_000913.3.
WP_001187819.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74970; AAC74970; b1900.
BAA15720; BAA15720; BAA15720.
GeneIDi946408.
KEGGiecj:JW1888.
eco:b1900.
PATRICi32119125. VBIEscCol129921_1980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06091 Genomic DNA. Translation: CAA29477.1.
U00096 Genomic DNA. Translation: AAC74970.1.
AP009048 Genomic DNA. Translation: BAA15720.1.
PIRiS01074.
RefSeqiNP_416413.1. NC_000913.3.
WP_001187819.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AAF3.
SMRiP0AAF3. Positions 8-502.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261851. 3 interactions.
DIPiDIP-48055N.
IntActiP0AAF3. 7 interactions.
MINTiMINT-1305954.
STRINGi511145.b1900.

Protein family/group databases

TCDBi3.A.1.2.2. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP0AAF3.
PRIDEiP0AAF3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74970; AAC74970; b1900.
BAA15720; BAA15720; BAA15720.
GeneIDi946408.
KEGGiecj:JW1888.
eco:b1900.
PATRICi32119125. VBIEscCol129921_1980.

Organism-specific databases

EchoBASEiEB0056.
EcoGeneiEG10058. araG.

Phylogenomic databases

eggNOGiENOG4105C2J. Bacteria.
COG1129. LUCA.
InParanoidiP0AAF3.
KOiK10539.
OMAiAKHEIYH.
PhylomeDBiP0AAF3.

Enzyme and pathway databases

BioCyciEcoCyc:ARAG-MONOMER.
ECOL316407:JW1888-MONOMER.
MetaCyc:ARAG-MONOMER.

Miscellaneous databases

PROiP0AAF3.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
PS51268. ARAG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARAG_ECOLI
AccessioniPrimary (citable) accession number: P0AAF3
Secondary accession number(s): P08531
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.