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Protein

Probable cadaverine/lysine antiporter

Gene

cadB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable cadaverine/lysine antiporter or part of it.

GO - Molecular functioni

  • lysine:cadaverine antiporter activity Source: EcoCyc
  • solute:proton symporter activity Source: EcoCyc

GO - Biological processi

  • amino acid transmembrane transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Antiport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:CADB-MONOMER.
ECOL316407:JW4093-MONOMER.
MetaCyc:CADB-MONOMER.

Protein family/group databases

TCDBi2.A.3.2.2. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cadaverine/lysine antiporter
Gene namesi
Name:cadB
Ordered Locus Names:b4132, JW4093
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10132. cadB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21
Transmembranei273 – 293HelicalSequence analysisAdd BLAST21
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Transmembranei354 – 374HelicalSequence analysisAdd BLAST21
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000542441 – 444Probable cadaverine/lysine antiporterAdd BLAST444

Proteomic databases

PaxDbiP0AAE8.
PRIDEiP0AAE8.

Expressioni

Inductioni

At low pH in the presence of lysine, achieves maximal levels under anaerobic conditions. Expression controlled by CadC.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260780. 7 interactors.
DIPiDIP-48089N.
IntActiP0AAE8. 2 interactors.
MINTiMINT-1247200.
STRINGi511145.b4132.

Structurei

3D structure databases

ProteinModelPortaliP0AAE8.
SMRiP0AAE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D5Q. Bacteria.
COG0531. LUCA.
HOGENOMiHOG000164506.
InParanoidiP0AAE8.
KOiK03757.
OMAiIAVACAN.
PhylomeDBiP0AAE8.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004754. Amino_acid_antiprt.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00905. 2A0302. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AAE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAKKIGLF ACTGVVAGNM MGSGIALLPA NLASIGGIAI WGWIISIIGA
60 70 80 90 100
MSLAYVYARL ATKNPQQGGP IAYAGEISPA FGFQTGVLYY HANWIGNLAI
110 120 130 140 150
GITAVSYLST FFPVLNDPVP AGIACIAIVW VFTFVNMLGG TWVSRLTTIG
160 170 180 190 200
LVLVLIPVVM TAIVGWHWFD AATYAANWNT ADTTDGHAII KSILLCLWAF
210 220 230 240 250
VGVESAAVST GMVKNPKRTV PLATMLGTGL AGIVYIAATQ VLSGMYPSSV
260 270 280 290 300
MAASGAPFAI SASTILGNWA APLVSAFTAF ACLTSLGSWM MLVGQAGVRA
310 320 330 340 350
ANDGNFPKVY GEVDSNGIPK KGLLLAAVKM TALMILITLM NSAGGKASDL
360 370 380 390 400
FGELTGIAVL LTMLPYFYSC VDLIRFEGVN IRNFVSLICS VLGCVFCFIA
410 420 430 440
LMGASSFELA GTFIVSLIIL MFYARKMHER QSHSMDNHTA SNAH
Length:444
Mass (Da):46,665
Last modified:October 11, 2005 - v1
Checksum:iE87913B449B0500A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M67452 Genomic DNA. Translation: AAA23532.1.
M76411 Genomic DNA. Translation: AAA23535.1.
U14003 Genomic DNA. Translation: AAA97032.1.
U00096 Genomic DNA. Translation: AAC77093.1.
AP009048 Genomic DNA. Translation: BAE78135.1.
PIRiA41842.
RefSeqiNP_418556.1. NC_000913.3.
WP_000092909.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77093; AAC77093; b4132.
BAE78135; BAE78135; BAE78135.
GeneIDi948654.
KEGGiecj:JW4093.
eco:b4132.
PATRICi32123831. VBIEscCol129921_4264.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M67452 Genomic DNA. Translation: AAA23532.1.
M76411 Genomic DNA. Translation: AAA23535.1.
U14003 Genomic DNA. Translation: AAA97032.1.
U00096 Genomic DNA. Translation: AAC77093.1.
AP009048 Genomic DNA. Translation: BAE78135.1.
PIRiA41842.
RefSeqiNP_418556.1. NC_000913.3.
WP_000092909.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AAE8.
SMRiP0AAE8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260780. 7 interactors.
DIPiDIP-48089N.
IntActiP0AAE8. 2 interactors.
MINTiMINT-1247200.
STRINGi511145.b4132.

Protein family/group databases

TCDBi2.A.3.2.2. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

PaxDbiP0AAE8.
PRIDEiP0AAE8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77093; AAC77093; b4132.
BAE78135; BAE78135; BAE78135.
GeneIDi948654.
KEGGiecj:JW4093.
eco:b4132.
PATRICi32123831. VBIEscCol129921_4264.

Organism-specific databases

EchoBASEiEB0130.
EcoGeneiEG10132. cadB.

Phylogenomic databases

eggNOGiENOG4105D5Q. Bacteria.
COG0531. LUCA.
HOGENOMiHOG000164506.
InParanoidiP0AAE8.
KOiK03757.
OMAiIAVACAN.
PhylomeDBiP0AAE8.

Enzyme and pathway databases

BioCyciEcoCyc:CADB-MONOMER.
ECOL316407:JW4093-MONOMER.
MetaCyc:CADB-MONOMER.

Miscellaneous databases

PROiP0AAE8.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004754. Amino_acid_antiprt.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00905. 2A0302. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCADB_ECOLI
AccessioniPrimary (citable) accession number: P0AAE8
Secondary accession number(s): P23891, Q2M6H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.