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P0AAE8 (CADB_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable cadaverine/lysine antiporter
Gene names
Name:cadB
Ordered Locus Names:b4132, JW4093
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable cadaverine/lysine antiporter or part of it.

Subcellular location

Cell inner membrane; Multi-pass membrane protein Ref.6.

Induction

At low pH in the presence of lysine, achieves maximal levels under anaerobic conditions. Expression controlled by CadC. Ref.1

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 444444Probable cadaverine/lysine antiporter
PRO_0000054244

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane35 – 5521Helical; Potential
Transmembrane68 – 8821Helical; Potential
Transmembrane95 – 11521Helical; Potential
Transmembrane123 – 14321Helical; Potential
Transmembrane149 – 16921Helical; Potential
Transmembrane193 – 21321Helical; Potential
Transmembrane222 – 24221Helical; Potential
Transmembrane250 – 27021Helical; Potential
Transmembrane273 – 29321Helical; Potential
Transmembrane323 – 34321Helical; Potential
Transmembrane354 – 37421Helical; Potential
Transmembrane384 – 40421Helical; Potential
Transmembrane405 – 42521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P0AAE8 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: E87913B449B0500A

FASTA44446,665
        10         20         30         40         50         60 
MSSAKKIGLF ACTGVVAGNM MGSGIALLPA NLASIGGIAI WGWIISIIGA MSLAYVYARL 

        70         80         90        100        110        120 
ATKNPQQGGP IAYAGEISPA FGFQTGVLYY HANWIGNLAI GITAVSYLST FFPVLNDPVP 

       130        140        150        160        170        180 
AGIACIAIVW VFTFVNMLGG TWVSRLTTIG LVLVLIPVVM TAIVGWHWFD AATYAANWNT 

       190        200        210        220        230        240 
ADTTDGHAII KSILLCLWAF VGVESAAVST GMVKNPKRTV PLATMLGTGL AGIVYIAATQ 

       250        260        270        280        290        300 
VLSGMYPSSV MAASGAPFAI SASTILGNWA APLVSAFTAF ACLTSLGSWM MLVGQAGVRA 

       310        320        330        340        350        360 
ANDGNFPKVY GEVDSNGIPK KGLLLAAVKM TALMILITLM NSAGGKASDL FGELTGIAVL 

       370        380        390        400        410        420 
LTMLPYFYSC VDLIRFEGVN IRNFVSLICS VLGCVFCFIA LMGASSFELA GTFIVSLIIL 

       430        440 
MFYARKMHER QSHSMDNHTA SNAH

« Hide

References

« Hide 'large scale' references
[1]"Identification of elements involved in transcriptional regulation of the Escherichia coli cad operon by external pH."
Watson N., Dunyak D.S., Rosey E.L., Slonczewski J.L., Olson E.R.
J. Bacteriol. 174:530-540(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
Strain: JLS821.
[2]"Nucleotide sequence of the Escherichia coli cad operon: a system for neutralization of low extracellular pH."
Meng S.-Y., Bennett G.N.
J. Bacteriol. 174:2659-2669(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes."
Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.
Nucleic Acids Res. 23:2105-2119(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[5]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[6]"Global topology analysis of the Escherichia coli inner membrane proteome."
Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
Strain: K12 / MG1655 / ATCC 47076.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M67452 Genomic DNA. Translation: AAA23532.1.
M76411 Genomic DNA. Translation: AAA23535.1.
U14003 Genomic DNA. Translation: AAA97032.1.
U00096 Genomic DNA. Translation: AAC77093.1.
AP009048 Genomic DNA. Translation: BAE78135.1.
PIRA41842.
RefSeqNP_418556.1. NC_000913.2.
YP_492276.1. NC_007779.1.

3D structure databases

ProteinModelPortalP0AAE8.
SMRP0AAE8. Positions 8-424.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-48089N.
IntActP0AAE8. 2 interactions.
MINTMINT-1247200.
STRING511145.b4132.

Protein family/group databases

TCDB2.A.3.2.2. amino acid-polyamine-organocation (APC) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC77093; AAC77093; b4132.
BAE78135; BAE78135; BAE78135.
GeneID12931786.
948654.
KEGGecj:Y75_p4020.
eco:b4132.
PATRIC32123831. VBIEscCol129921_4264.

Organism-specific databases

EchoBASEEB0130.
EcoGeneEG10132. cadB.

Phylogenomic databases

eggNOGCOG0531.
HOGENOMHOG000164506.
KOK03757.
OMANITPMMP.
ProtClustDBPRK10435.

Enzyme and pathway databases

BioCycEcoCyc:CADB-MONOMER.
ECOL316407:JW4093-MONOMER.
MetaCyc:CADB-MONOMER.

Gene expression databases

GenevestigatorP0AAE8.

Family and domain databases

InterProIPR002293. AA/rel_permease1.
IPR004754. Amino_acid_antiprt.
[Graphical view]
PANTHERPTHR11785. PTHR11785. 1 hit.
PIRSFPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsTIGR00905. 2A0302. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCADB_ECOLI
AccessionPrimary (citable) accession number: P0AAE8
Secondary accession number(s): P23891, Q2M6H1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: May 1, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families

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