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Protein

Proline-specific permease ProY

Gene

proY

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Permease that is involved in the transport across the cytoplasmic membrane of proline.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:PROY-MONOMER.
ECOL316407:JW5055-MONOMER.

Protein family/group databases

TCDBi2.A.3.1.23. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-specific permease ProY
Gene namesi
Name:proY
Synonyms:yajM
Ordered Locus Names:b0402, JW5055
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13609. proY.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717CytoplasmicSequence analysisAdd
BLAST
Transmembranei18 – 3821HelicalSequence analysisAdd
BLAST
Transmembranei39 – 5921HelicalSequence analysisAdd
BLAST
Topological domaini60 – 8425CytoplasmicSequence analysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence analysisAdd
BLAST
Topological domaini106 – 1138PeriplasmicSequence analysis
Transmembranei114 – 13421HelicalSequence analysisAdd
BLAST
Topological domaini135 – 15622CytoplasmicSequence analysisAdd
BLAST
Transmembranei157 – 17721HelicalSequence analysisAdd
BLAST
Topological domaini178 – 19720PeriplasmicSequence analysisAdd
BLAST
Transmembranei198 – 21821HelicalSequence analysisAdd
BLAST
Topological domaini219 – 24224CytoplasmicSequence analysisAdd
BLAST
Transmembranei243 – 26321HelicalSequence analysisAdd
BLAST
Topological domaini264 – 27714PeriplasmicSequence analysisAdd
BLAST
Transmembranei278 – 29821HelicalSequence analysisAdd
BLAST
Topological domaini299 – 33133CytoplasmicSequence analysisAdd
BLAST
Transmembranei332 – 35221HelicalSequence analysisAdd
BLAST
Topological domaini353 – 3553PeriplasmicSequence analysis
Transmembranei356 – 37621HelicalSequence analysisAdd
BLAST
Topological domaini377 – 39923CytoplasmicSequence analysisAdd
BLAST
Transmembranei400 – 42021HelicalSequence analysisAdd
BLAST
Topological domaini421 – 4244PeriplasmicSequence analysis
Transmembranei425 – 44521HelicalSequence analysisAdd
BLAST
Topological domaini446 – 45712CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Proline-specific permease ProYPRO_0000054207Add
BLAST

Proteomic databases

PaxDbiP0AAE2.
PRIDEiP0AAE2.

Interactioni

Protein-protein interaction databases

BioGridi4262813. 4 interactions.
DIPiDIP-47977N.
IntActiP0AAE2. 1 interaction.
MINTiMINT-1317808.
STRINGi511145.b0402.

Structurei

3D structure databases

ProteinModelPortaliP0AAE2.
SMRiP0AAE2. Positions 19-360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C85. Bacteria.
COG1113. LUCA.
HOGENOMiHOG000261849.
InParanoidiP0AAE2.
KOiK11736.
OMAiVVMMMAL.
OrthoDBiEOG6HQSQM.
PhylomeDBiP0AAE2.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AAE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKNKLKRG LSTRHIRFMA LGSAIGTGLF YGSADAIKMA GPSVLLAYII
60 70 80 90 100
GGIAAYIIMR ALGEMSVHNP AASSFSRYAQ ENLGPLAGYI TGWTYCFEIL
110 120 130 140 150
IVAIADVTAF GIYMGVWFPT VPHWIWVLSV VLIICAVNLM SVKVFGELEF
160 170 180 190 200
WFSFFKVATI IIMIVAGFGI IIWGIGNGGQ PTGIHNLWSN GGFFSNGWLG
210 220 230 240 250
MVMSLQMVMF AYGGIEIIGI TAGEAKDPEK SIPRAINSVP MRILVFYVGT
260 270 280 290 300
LFVIMSIYPW NQVGTAGSPF VLTFQHMGIT FAASILNFVV LTASLSAINS
310 320 330 340 350
DVFGVGRMLH GMAEQGSAPK IFSKTSRRGI PWVTVLVMTT ALLFAVYLNY
360 370 380 390 400
IMPENVFLVI ASLATFATVW VWIMILLSQI AFRRRLPPEE VKALKFKVPG
410 420 430 440 450
GVATTIGGLI FLLFIIGLIG YHPDTRISLY VGFAWIVVLL IGWMFKRRHD

RQLAENQ
Length:457
Mass (Da):50,216
Last modified:October 11, 2005 - v1
Checksum:i5F2819526EA06BD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA. Translation: AAB40158.1.
U00096 Genomic DNA. Translation: AAC73505.1.
AP009048 Genomic DNA. Translation: BAE76182.1.
PIRiB64769.
RefSeqiNP_414936.1. NC_000913.3.
WP_001295329.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73505; AAC73505; b0402.
BAE76182; BAE76182; BAE76182.
GeneIDi945050.
KEGGiecj:JW5055.
eco:b0402.
PATRICi32115953. VBIEscCol129921_0418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA. Translation: AAB40158.1.
U00096 Genomic DNA. Translation: AAC73505.1.
AP009048 Genomic DNA. Translation: BAE76182.1.
PIRiB64769.
RefSeqiNP_414936.1. NC_000913.3.
WP_001295329.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AAE2.
SMRiP0AAE2. Positions 19-360.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262813. 4 interactions.
DIPiDIP-47977N.
IntActiP0AAE2. 1 interaction.
MINTiMINT-1317808.
STRINGi511145.b0402.

Protein family/group databases

TCDBi2.A.3.1.23. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

PaxDbiP0AAE2.
PRIDEiP0AAE2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73505; AAC73505; b0402.
BAE76182; BAE76182; BAE76182.
GeneIDi945050.
KEGGiecj:JW5055.
eco:b0402.
PATRICi32115953. VBIEscCol129921_0418.

Organism-specific databases

EchoBASEiEB3376.
EcoGeneiEG13609. proY.

Phylogenomic databases

eggNOGiENOG4105C85. Bacteria.
COG1113. LUCA.
HOGENOMiHOG000261849.
InParanoidiP0AAE2.
KOiK11736.
OMAiVVMMMAL.
OrthoDBiEOG6HQSQM.
PhylomeDBiP0AAE2.

Enzyme and pathway databases

BioCyciEcoCyc:PROY-MONOMER.
ECOL316407:JW5055-MONOMER.

Miscellaneous databases

PROiP0AAE2.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiPROY_ECOLI
AccessioniPrimary (citable) accession number: P0AAE2
Secondary accession number(s): P77327, Q2MC24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: February 17, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.