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Protein

D-serine/D-alanine/glycine transporter

Gene

cycA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine.

GO - Molecular functioni

  • antibiotic transmembrane transporter activity Source: EcoCyc
  • beta-alanine transmembrane transporter activity Source: EcoCyc
  • D-alanine transmembrane transporter activity Source: EcoCyc
  • D-serine transmembrane transporter activity Source: EcoCyc
  • glycine transmembrane transporter activity Source: EcoCyc
  • L-alanine transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • antibiotic transport Source: EcoCyc
  • beta-alanine transport Source: EcoCyc
  • D-alanine transport Source: EcoCyc
  • D-serine transport Source: EcoCyc
  • glycine transport Source: EcoCyc
  • L-alanine transport Source: EcoCyc

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:CYCA-MONOMER
MetaCyc:CYCA-MONOMER

Protein family/group databases

TCDBi2.A.3.1.7 the amino acid-polyamine-organocation (apc) family

Names & Taxonomyi

Protein namesi
Recommended name:
D-serine/D-alanine/glycine transporter
Gene namesi
Name:cycA
Synonyms:dagA, ytfD
Ordered Locus Names:b4208, JW4166
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12504 cycA

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Topological domaini72 – 101CytoplasmicSequence analysisAdd BLAST30
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Topological domaini123 – 136PeriplasmicSequence analysisAdd BLAST14
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Topological domaini158 – 161CytoplasmicSequence analysis4
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 210PeriplasmicSequence analysisAdd BLAST28
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Topological domaini232 – 255CytoplasmicSequence analysisAdd BLAST24
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Topological domaini277 – 282PeriplasmicSequence analysis6
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Topological domaini304 – 349CytoplasmicSequence analysisAdd BLAST46
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Topological domaini392 – 412CytoplasmicSequence analysisAdd BLAST21
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Topological domaini434 – 440PeriplasmicSequence analysis7
Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Topological domaini462 – 470CytoplasmicSequence analysis1 Publication9

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000541991 – 470D-serine/D-alanine/glycine transporterAdd BLAST470

Proteomic databases

EPDiP0AAE0
PaxDbiP0AAE0
PRIDEiP0AAE0

Interactioni

Protein-protein interaction databases

BioGridi4262718171 interactors.
DIPiDIP-9359N
IntActiP0AAE0 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliP0AAE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C85 Bacteria
COG1113 LUCA
HOGENOMiHOG000261849
InParanoidiP0AAE0
KOiK11737
OMAiINFITRY
PhylomeDBiP0AAE0

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004840 Amoino_acid_permease_CS
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
PROSITEiView protein in PROSITE
PS00218 AMINO_ACID_PERMEASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

P0AAE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDQVKVVAD DQAPAEQSLR RNLTNRHIQL IAIGGAIGTG LFMGSGKTIS
60 70 80 90 100
LAGPSIIFVY MIIGFMLFFV MRAMGELLLS NLEYKSFSDF ASDLLGPWAG
110 120 130 140 150
YFTGWTYWFC WVVTGMADVV AITAYAQFWF PDLSDWVASL AVIVLLLTLN
160 170 180 190 200
LATVKMFGEM EFWFAMIKIV AIVSLIVVGL VMVAMHFQSP TGVEASFAHL
210 220 230 240 250
WNDGGWFPKG LSGFFAGFQI AVFAFVGIEL VGTTAAETKD PEKSLPRAIN
260 270 280 290 300
SIPIRIIMFY VFALIVIMSV TPWSSVVPEK SPFVELFVLV GLPAAASVIN
310 320 330 340 350
FVVLTSAASS ANSGVFSTSR MLFGLAQEGV APKAFAKLSK RAVPAKGLTF
360 370 380 390 400
SCICLLGGVV MLYVNPSVIG AFTMITTVSA ILFMFVWTII LCSYLVYRKQ
410 420 430 440 450
RPHLHEKSIY KMPLGKLMCW VCMAFFVFVV VLLTLEDDTR QALLVTPLWF
460 470
IALGLGWLFI GKKRAAELRK
Length:470
Mass (Da):51,660
Last modified:October 11, 2005 - v1
Checksum:iF9279E48D838EAF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97104.1
U00096 Genomic DNA Translation: AAC77165.1
AP009048 Genomic DNA Translation: BAE78209.1
PIRiS56433
RefSeqiNP_418629.1, NC_000913.3
WP_000228346.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77165; AAC77165; b4208
BAE78209; BAE78209; BAE78209
GeneIDi948725
KEGGiecj:JW4166
eco:b4208
PATRICifig|1411691.4.peg.2493

Similar proteinsi

Entry informationi

Entry nameiCYCA_ECOLI
AccessioniPrimary (citable) accession number: P0AAE0
Secondary accession number(s): P39312, Q2M697
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome