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Protein

Threonine/serine transporter TdcC

Gene

tdcC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system).UniRule annotation1 Publication

GO - Molecular functioni

  • L-serine transmembrane transporter activity Source: EcoCyc
  • L-threonine transmembrane transporter activity Source: EcoCyc
  • solute:proton symporter activity Source: EcoCyc
  • threonine efflux transmembrane transporter activity Source: InterPro

GO - Biological processi

  • amino acid transport Source: EcoliWiki
  • L-serine transport Source: EcoCyc
  • threonine transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Symport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:TDCC-MONOMER.
ECOL316407:JW3087-MONOMER.
MetaCyc:TDCC-MONOMER.

Protein family/group databases

TCDBi2.A.42.2.2. the hydroxy/aromatic amino acid permease (haaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine/serine transporter TdcCUniRule annotation
Alternative name(s):
H(+)/threonine-serine symporterUniRule annotation
Gene namesi
Name:tdcCUniRule annotation
Ordered Locus Names:b3116, JW3087
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10991. tdcC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalUniRule annotationAdd BLAST21
Transmembranei44 – 64HelicalUniRule annotationAdd BLAST21
Transmembranei97 – 117HelicalUniRule annotationAdd BLAST21
Transmembranei140 – 160HelicalUniRule annotationAdd BLAST21
Transmembranei163 – 183HelicalUniRule annotationAdd BLAST21
Transmembranei207 – 227HelicalUniRule annotationAdd BLAST21
Transmembranei261 – 281HelicalUniRule annotationAdd BLAST21
Transmembranei311 – 331HelicalUniRule annotationAdd BLAST21
Transmembranei366 – 386HelicalUniRule annotationAdd BLAST21
Transmembranei389 – 409HelicalUniRule annotationAdd BLAST21
Transmembranei423 – 443HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: EcoliWiki
  • integral component of plasma membrane Source: EcoliWiki
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938121 – 443Threonine/serine transporter TdcCAdd BLAST443

Proteomic databases

PaxDbiP0AAD8.
PRIDEiP0AAD8.

Interactioni

Protein-protein interaction databases

BioGridi4262418. 8 interactors.
DIPiDIP-48056N.
IntActiP0AAD8. 1 interactor.
MINTiMINT-1252560.
STRINGi511145.b3116.

Structurei

3D structure databases

ProteinModelPortaliP0AAD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108MST. Bacteria.
COG0814. LUCA.
HOGENOMiHOG000270787.
KOiK03838.
OMAiANHFSSM.
PhylomeDBiP0AAD8.

Family and domain databases

HAMAPiMF_01583. Thr_Ser_transp_TdcC. 1 hit.
InterProiIPR004694. Hydroxy_aa_transpt.
IPR023726. Thr/Ser_transpt_TdcC.
IPR018227. Tryptophan/tyrosine_permease.
[Graphical view]
PfamiPF03222. Trp_Tyr_perm. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00814. stp. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AAD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSDSIVSS QTKQSSWRKS DTTWTLGLFG TAIGAGVLFF PIRAGFGGLI
60 70 80 90 100
PILLMLVLAY PIAFYCHRAL ARLCLSGSNP SGNITETVEE HFGKTGGVVI
110 120 130 140 150
TFLYFFAICP LLWIYGVTIT NTFMTFWENQ LGFAPLNRGF VALFLLLLMA
160 170 180 190 200
FVIWFGKDLM VKVMSYLVWP FIASLVLISL SLIPYWNSAV IDQVDLGSLS
210 220 230 240 250
LTGHDGILIT VWLGISIMVF SFNFSPIVSS FVVSKREEYE KDFGRDFTER
260 270 280 290 300
KCSQIISRAS MLMVAVVMFF AFSCLFTLSP ANMAEAKAQN IPVLSYLANH
310 320 330 340 350
FASMTGTKTT FAITLEYAAS IIALVAIFKS FFGHYLGTLE GLNGLVLKFG
360 370 380 390 400
YKGDKTKVSL GKLNTISMIF IMGSTWVVAY ANPNILDLIE AMGAPIIASL
410 420 430 440
LCLLPMYAIR KAPSLAKYRG RLDNVFVTVI GLLTILNIVY KLF
Length:443
Mass (Da):48,879
Last modified:October 11, 2005 - v1
Checksum:i761E524AEC4D2656
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70Missing in CAA32594 (PubMed:2660107).Curated1
Sequence conflicti70Missing in AAA24662 (PubMed:3053659).Curated1
Sequence conflicti431 – 443GLLTI…VYKLF → VC in CAA32594 (PubMed:2660107).CuratedAdd BLAST13
Sequence conflicti431 – 443GLLTI…VYKLF → VC in AAA24662 (PubMed:3053659).CuratedAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14430 Genomic DNA. Translation: CAA32594.1.
M23638 Genomic DNA. Translation: AAA24662.1.
U18997 Genomic DNA. Translation: AAA57920.1.
U00096 Genomic DNA. Translation: AAC76151.1.
AP009048 Genomic DNA. Translation: BAE77165.1.
PIRiA65101. BVECTC.
RefSeqiNP_417586.1. NC_000913.3.
WP_000107723.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76151; AAC76151; b3116.
BAE77165; BAE77165; BAE77165.
GeneIDi947629.
KEGGiecj:JW3087.
eco:b3116.
PATRICi32121648. VBIEscCol129921_3210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14430 Genomic DNA. Translation: CAA32594.1.
M23638 Genomic DNA. Translation: AAA24662.1.
U18997 Genomic DNA. Translation: AAA57920.1.
U00096 Genomic DNA. Translation: AAC76151.1.
AP009048 Genomic DNA. Translation: BAE77165.1.
PIRiA65101. BVECTC.
RefSeqiNP_417586.1. NC_000913.3.
WP_000107723.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AAD8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262418. 8 interactors.
DIPiDIP-48056N.
IntActiP0AAD8. 1 interactor.
MINTiMINT-1252560.
STRINGi511145.b3116.

Protein family/group databases

TCDBi2.A.42.2.2. the hydroxy/aromatic amino acid permease (haaap) family.

Proteomic databases

PaxDbiP0AAD8.
PRIDEiP0AAD8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76151; AAC76151; b3116.
BAE77165; BAE77165; BAE77165.
GeneIDi947629.
KEGGiecj:JW3087.
eco:b3116.
PATRICi32121648. VBIEscCol129921_3210.

Organism-specific databases

EchoBASEiEB0984.
EcoGeneiEG10991. tdcC.

Phylogenomic databases

eggNOGiENOG4108MST. Bacteria.
COG0814. LUCA.
HOGENOMiHOG000270787.
KOiK03838.
OMAiANHFSSM.
PhylomeDBiP0AAD8.

Enzyme and pathway databases

BioCyciEcoCyc:TDCC-MONOMER.
ECOL316407:JW3087-MONOMER.
MetaCyc:TDCC-MONOMER.

Miscellaneous databases

PROiP0AAD8.

Family and domain databases

HAMAPiMF_01583. Thr_Ser_transp_TdcC. 1 hit.
InterProiIPR004694. Hydroxy_aa_transpt.
IPR023726. Thr/Ser_transpt_TdcC.
IPR018227. Tryptophan/tyrosine_permease.
[Graphical view]
PfamiPF03222. Trp_Tyr_perm. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00814. stp. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTDCC_ECOLI
AccessioniPrimary (citable) accession number: P0AAD8
Secondary accession number(s): P11867, Q2M991
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.