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Protein

Serine transporter

Gene

sdaC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:SDAC-MONOMER.
ECOL316407:JW2767-MONOMER.
MetaCyc:SDAC-MONOMER.

Protein family/group databases

TCDBi2.A.42.2.1. the hydroxy/aromatic amino acid permease (haaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine transporter
Gene namesi
Name:sdaC
Synonyms:dcrA
Ordered Locus Names:b2796, JW2767
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12142. sdaC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Topological domaini44 – 46PeriplasmicSequence analysis3
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Topological domaini68 – 99CytoplasmicSequence analysisAdd BLAST32
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Topological domaini121 – 140PeriplasmicSequence analysisAdd BLAST20
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 163CytoplasmicSequence analysis2
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 201PeriplasmicSequence analysisAdd BLAST17
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Topological domaini223 – 249CytoplasmicSequence analysisAdd BLAST27
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21
Topological domaini271 – 297PeriplasmicSequence analysisAdd BLAST27
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Topological domaini319 – 347CytoplasmicSequence analysisAdd BLAST29
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369PeriplasmicSequence analysis1
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Topological domaini391 – 406CytoplasmicSequence analysisAdd BLAST16
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Topological domaini428 – 429PeriplasmicSequence analysis2

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoliWiki
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938081 – 429Serine transporterAdd BLAST429

Proteomic databases

PaxDbiP0AAD6.
PRIDEiP0AAD6.

Expressioni

Inductioni

By leucine and by growth in rich medium. Repressed by LeuO. Part of the sdaCB operon.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261307. 17 interactors.
STRINGi511145.b2796.

Structurei

3D structure databases

ProteinModelPortaliP0AAD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C44. Bacteria.
COG0814. LUCA.
HOGENOMiHOG000270787.
KOiK03837.
OMAiHQLHLPS.
PhylomeDBiP0AAD6.

Family and domain databases

InterProiIPR004694. Hydroxy_aa_transpt.
[Graphical view]
TIGRFAMsiTIGR00814. stp. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AAD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METTQTSTIA SKDSRSAWRK TDTMWMLGLY GTAIGAGVLF LPINAGVGGM
60 70 80 90 100
IPLIIMAILA FPMTFFAHRG LTRFVLSGKN PGEDITEVVE EHFGIGAGKL
110 120 130 140 150
ITLLYFFAIY PILLVYSVAI TNTVESFMSH QLGMTPPPRA ILSLILIVGM
160 170 180 190 200
MTIVRFGEQM IVKAMSILVF PFVGVLMLLA LYLIPQWNGA ALETLSLDTA
210 220 230 240 250
SATGNGLWMT LWLAIPVMVF SFNHSPIISS FAVAKREEYG DMAEQKCSKI
260 270 280 290 300
LAFAHIMMVL TVMFFVFSCV LSLTPADLAA AKEQNISILS YLANHFNAPV
310 320 330 340 350
IAWMAPIIAI IAITKSFLGH YLGAREGFNG MVIKSLRGKG KSIEINKLNR
360 370 380 390 400
ITALFMLVTT WIVATLNPSI LGMIETLGGP IIAMILFLMP MYAIQKVPAM
410 420
RKYSGHISNV FVVVMGLIAI SAIFYSLFS
Length:429
Mass (Da):46,906
Last modified:October 11, 2005 - v1
Checksum:iF97AB93F84A38FE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01233 Genomic DNA. Translation: AAA50169.1.
U29581 Genomic DNA. Translation: AAB40446.1.
U00096 Genomic DNA. Translation: AAC75838.1.
AP009048 Genomic DNA. Translation: BAE76868.1.
PIRiS45633.
RefSeqiNP_417276.1. NC_000913.3.
WP_000450476.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75838; AAC75838; b2796.
BAE76868; BAE76868; BAE76868.
GeneIDi947264.
KEGGiecj:JW2767.
eco:b2796.
PATRICi32121008. VBIEscCol129921_2896.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01233 Genomic DNA. Translation: AAA50169.1.
U29581 Genomic DNA. Translation: AAB40446.1.
U00096 Genomic DNA. Translation: AAC75838.1.
AP009048 Genomic DNA. Translation: BAE76868.1.
PIRiS45633.
RefSeqiNP_417276.1. NC_000913.3.
WP_000450476.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AAD6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261307. 17 interactors.
STRINGi511145.b2796.

Protein family/group databases

TCDBi2.A.42.2.1. the hydroxy/aromatic amino acid permease (haaap) family.

Proteomic databases

PaxDbiP0AAD6.
PRIDEiP0AAD6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75838; AAC75838; b2796.
BAE76868; BAE76868; BAE76868.
GeneIDi947264.
KEGGiecj:JW2767.
eco:b2796.
PATRICi32121008. VBIEscCol129921_2896.

Organism-specific databases

EchoBASEiEB2063.
EcoGeneiEG12142. sdaC.

Phylogenomic databases

eggNOGiENOG4105C44. Bacteria.
COG0814. LUCA.
HOGENOMiHOG000270787.
KOiK03837.
OMAiHQLHLPS.
PhylomeDBiP0AAD6.

Enzyme and pathway databases

BioCyciEcoCyc:SDAC-MONOMER.
ECOL316407:JW2767-MONOMER.
MetaCyc:SDAC-MONOMER.

Miscellaneous databases

PROiP0AAD6.

Family and domain databases

InterProiIPR004694. Hydroxy_aa_transpt.
[Graphical view]
TIGRFAMsiTIGR00814. stp. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSDAC_ECOLI
AccessioniPrimary (citable) accession number: P0AAD6
Secondary accession number(s): P36559, Q2MA38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.