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Protein

Tyrosine-specific transport protein

Gene

tyrP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transporting tyrosine across the cytoplasmic membrane.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:TYRP-MONOMER.
ECOL316407:JW1895-MONOMER.

Protein family/group databases

TCDBi2.A.42.1.1. the hydroxy/aromatic amino acid permease (haaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-specific transport protein
Alternative name(s):
Tyrosine permease
Gene namesi
Name:tyrP
Ordered Locus Names:b1907, JW1895
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11041. tyrP.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 34PeriplasmicSequence analysis5
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 80CytoplasmicSequence analysisAdd BLAST25
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 121PeriplasmicSequence analysisAdd BLAST20
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 147CytoplasmicSequence analysis5
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Topological domaini169 – 183PeriplasmicSequence analysisAdd BLAST15
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 216CytoplasmicSequence analysisAdd BLAST12
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 274PeriplasmicSequence analysisAdd BLAST37
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Topological domaini296 – 307CytoplasmicSequence analysisAdd BLAST12
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 331PeriplasmicSequence analysis3
Transmembranei332 – 352HelicalSequence analysisAdd BLAST21
Topological domaini353 – 375CytoplasmicSequence analysisAdd BLAST23
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Topological domaini397 – 403PeriplasmicSequence analysis7

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoliWiki
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938041 – 403Tyrosine-specific transport proteinAdd BLAST403

Proteomic databases

PaxDbiP0AAD4.
PRIDEiP0AAD4.

Expressioni

Inductioni

Repressed by tyrosine and induced by phenylalanine under the control of regulatory protein TyrR.

Interactioni

Protein-protein interaction databases

BioGridi4262055. 7 interactors.
DIPiDIP-48105N.
IntActiP0AAD4. 1 interactor.
MINTiMINT-1305835.
STRINGi511145.b1907.

Structurei

3D structure databases

ProteinModelPortaliP0AAD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105E0U. Bacteria.
COG0814. LUCA.
HOGENOMiHOG000269673.
InParanoidiP0AAD4.
KOiK03834.
OMAiALLMPHI.
PhylomeDBiP0AAD4.

Family and domain databases

InterProiIPR002091. ArAA_permease.
IPR013061. Trp/try_permease_CS.
IPR013059. Trp_tyr_transpt.
IPR018227. Tryptophan/tyrosine_permease.
[Graphical view]
PfamiPF03222. Trp_Tyr_perm. 1 hit.
[Graphical view]
PRINTSiPR00166. AROAAPRMEASE.
TIGRFAMsiTIGR00837. araaP. 1 hit.
PROSITEiPS00594. AROMATIC_AA_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AAD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNRTLGSVF IVAGTTIGAG MLAMPLAAAG VGFSVTLILL IGLWALMCYT
60 70 80 90 100
ALLLLEVYQH VPADTGLGTL AKRYLGRYGQ WLTGFSMMFL MYALTAAYIS
110 120 130 140 150
GAGELLASSI SDWTGISMSA TAGVLLFTFV AGGVVCVGTS LVDLFNRFLF
160 170 180 190 200
SAKIIFLVVM LVLLLPHIHK VNLLTLPLQQ GLALSAIPVI FTSFGFHGSV
210 220 230 240 250
PSIVSYMDGN IRKLRWVFII GSAIPLVAYI FWQVATLGSI DSTTFMGLLA
260 270 280 290 300
NHAGLNGLLQ ALREMVASPH VELAVHLFAD LALATSFLGV ALGLFDYLAD
310 320 330 340 350
LFQRSNTVGG RLQTGAITFL PPLAFALFYP RGFVMALGYA GVALAVLALI
360 370 380 390 400
IPSLLTWQSR KHNPQAGYRV KGGRPALVVV FLCGIAVIGV QFLIAAGLLP

EVG
Length:403
Mass (Da):42,819
Last modified:October 11, 2005 - v1
Checksum:i7BECCAA833679796
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti131 – 135AGGVV → RRVAWL in AAA24705 (PubMed:3049553).Curated5
Sequence conflicti222 – 224SAI → ECD in AAA24705 (PubMed:3049553).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23240 Genomic DNA. Translation: AAA24705.1.
U00096 Genomic DNA. Translation: AAC74977.1.
AP009048 Genomic DNA. Translation: BAA15730.1.
PIRiC64954. GRECY.
RefSeqiNP_416420.1. NC_000913.3.
WP_000797560.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74977; AAC74977; b1907.
BAA15730; BAA15730; BAA15730.
GeneIDi946412.
KEGGiecj:JW1895.
eco:b1907.
PATRICi32119145. VBIEscCol129921_1990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23240 Genomic DNA. Translation: AAA24705.1.
U00096 Genomic DNA. Translation: AAC74977.1.
AP009048 Genomic DNA. Translation: BAA15730.1.
PIRiC64954. GRECY.
RefSeqiNP_416420.1. NC_000913.3.
WP_000797560.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AAD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262055. 7 interactors.
DIPiDIP-48105N.
IntActiP0AAD4. 1 interactor.
MINTiMINT-1305835.
STRINGi511145.b1907.

Protein family/group databases

TCDBi2.A.42.1.1. the hydroxy/aromatic amino acid permease (haaap) family.

Proteomic databases

PaxDbiP0AAD4.
PRIDEiP0AAD4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74977; AAC74977; b1907.
BAA15730; BAA15730; BAA15730.
GeneIDi946412.
KEGGiecj:JW1895.
eco:b1907.
PATRICi32119145. VBIEscCol129921_1990.

Organism-specific databases

EchoBASEiEB1034.
EcoGeneiEG11041. tyrP.

Phylogenomic databases

eggNOGiENOG4105E0U. Bacteria.
COG0814. LUCA.
HOGENOMiHOG000269673.
InParanoidiP0AAD4.
KOiK03834.
OMAiALLMPHI.
PhylomeDBiP0AAD4.

Enzyme and pathway databases

BioCyciEcoCyc:TYRP-MONOMER.
ECOL316407:JW1895-MONOMER.

Miscellaneous databases

PROiP0AAD4.

Family and domain databases

InterProiIPR002091. ArAA_permease.
IPR013061. Trp/try_permease_CS.
IPR013059. Trp_tyr_transpt.
IPR018227. Tryptophan/tyrosine_permease.
[Graphical view]
PfamiPF03222. Trp_Tyr_perm. 1 hit.
[Graphical view]
PRINTSiPR00166. AROAAPRMEASE.
TIGRFAMsiTIGR00837. araaP. 1 hit.
PROSITEiPS00594. AROMATIC_AA_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTYRP_ECOLI
AccessioniPrimary (citable) accession number: P0AAD4
Secondary accession number(s): P18199, P76309
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.