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Protein

Tryptophan-specific transport protein

Gene

mtr

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transporting tryptophan across the cytoplasmic membrane.

GO - Molecular functioni

  • active transmembrane transporter activity Source: EcoCyc
  • high-affinity tryptophan transmembrane transporter activity Source: EcoCyc
  • symporter activity Source: EcoCyc

GO - Biological processi

  • amino acid transmembrane transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:MTR-MONOMER.
ECOL316407:JW3130-MONOMER.
MetaCyc:MTR-MONOMER.

Protein family/group databases

TCDBi2.A.42.1.2. the hydroxy/aromatic amino acid permease (haaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan-specific transport protein
Alternative name(s):
Tryptophan permease
Gene namesi
Name:mtr
Ordered Locus Names:b3161, JW3130
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10617. mtr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicCurated10
Transmembranei11 – 34HelicalCuratedAdd BLAST24
Topological domaini35 – 38PeriplasmicCurated4
Transmembranei39 – 61HelicalCuratedAdd BLAST23
Topological domaini62 – 86CytoplasmicCuratedAdd BLAST25
Transmembranei87 – 109HelicalCuratedAdd BLAST23
Topological domaini110 – 122PeriplasmicCuratedAdd BLAST13
Transmembranei123 – 145HelicalCuratedAdd BLAST23
Topological domaini146 – 151CytoplasmicCurated6
Transmembranei152 – 174HelicalCuratedAdd BLAST23
Topological domaini175 – 188PeriplasmicCuratedAdd BLAST14
Transmembranei189 – 210HelicalCuratedAdd BLAST22
Topological domaini211 – 227CytoplasmicCuratedAdd BLAST17
Transmembranei228 – 251HelicalCuratedAdd BLAST24
Topological domaini252 – 281PeriplasmicCuratedAdd BLAST30
Transmembranei282 – 303HelicalCuratedAdd BLAST22
Topological domaini304 – 321CytoplasmicCuratedAdd BLAST18
Transmembranei322 – 343HelicalCuratedAdd BLAST22
Transmembranei344 – 365HelicalCuratedAdd BLAST22
Topological domaini366 – 386CytoplasmicCuratedAdd BLAST21
Transmembranei387 – 409HelicalCuratedAdd BLAST23
Topological domaini410 – 414PeriplasmicCurated5

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoliWiki
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000937971 – 414Tryptophan-specific transport proteinAdd BLAST414

Proteomic databases

PaxDbiP0AAD2.
PRIDEiP0AAD2.

Expressioni

Inductioni

By phenylalanine under the control of regulatory protein TyrR.

Interactioni

Protein-protein interaction databases

BioGridi4259278. 178 interactors.
STRINGi511145.b3161.

Structurei

3D structure databases

ProteinModelPortaliP0AAD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CIC. Bacteria.
COG0814. LUCA.
HOGENOMiHOG000269674.
InParanoidiP0AAD2.
KOiK03835.
OMAiIWLLGTM.
PhylomeDBiP0AAD2.

Family and domain databases

InterProiIPR002091. ArAA_permease.
IPR013061. Trp/try_permease_CS.
IPR013059. Trp_tyr_transpt.
IPR018227. Tryptophan/tyrosine_permease.
[Graphical view]
PfamiPF03222. Trp_Tyr_perm. 1 hit.
[Graphical view]
PRINTSiPR00166. AROAAPRMEASE.
TIGRFAMsiTIGR00837. araaP. 1 hit.
PROSITEiPS00594. AROMATIC_AA_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AAD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLTTTQTS PSLLGGVVII GGTIIGAGMF SLPVVMSGAW FFWSMAALIF
60 70 80 90 100
TWFCMLHSGL MILEANLNYR IGSSFDTITK DLLGKGWNVV NGISIAFVLY
110 120 130 140 150
ILTYAYISAS GSILHHTFAE MSLNVPARAA GFGFALLVAF VVWLSTKAVS
160 170 180 190 200
RMTAIVLGAK VITFFLTFGS LLGHVQPATL FNVAESNASY APYLLMTLPF
210 220 230 240 250
CLASFGYHGN VPSLMKYYGK DPKTIVKCLV YGTLMALALY TIWLLATMGN
260 270 280 290 300
IPRPEFIGIA EKGGNIDVLV QALSGVLNSR SLDLLLVVFS NFAVASSFLG
310 320 330 340 350
VTLGLFDYLA DLFGFDDSAV GRLKTALLTF APPVVGGLLF PNGFLYAIGY
360 370 380 390 400
AGLAATIWAA IVPALLARAS RKRFGSPKFR VWGGKPMIAL ILVFGVGNAL
410
VHILSSFNLL PVYQ
Length:414
Mass (Da):44,333
Last modified:October 11, 2005 - v1
Checksum:i87BF42540862FDD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59862 Genomic DNA. Translation: AAA24182.1.
M58338 Genomic DNA. Translation: AAA24183.1.
U18997 Genomic DNA. Translation: AAA57964.1.
U00096 Genomic DNA. Translation: AAC76195.1.
AP009048 Genomic DNA. Translation: BAE77207.1.
PIRiA39187.
RefSeqiNP_417630.1. NC_000913.3.
WP_000224351.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76195; AAC76195; b3161.
BAE77207; BAE77207; BAE77207.
GeneIDi947675.
KEGGiecj:JW3130.
eco:b3161.
PATRICi32121740. VBIEscCol129921_3256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59862 Genomic DNA. Translation: AAA24182.1.
M58338 Genomic DNA. Translation: AAA24183.1.
U18997 Genomic DNA. Translation: AAA57964.1.
U00096 Genomic DNA. Translation: AAC76195.1.
AP009048 Genomic DNA. Translation: BAE77207.1.
PIRiA39187.
RefSeqiNP_417630.1. NC_000913.3.
WP_000224351.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AAD2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259278. 178 interactors.
STRINGi511145.b3161.

Protein family/group databases

TCDBi2.A.42.1.2. the hydroxy/aromatic amino acid permease (haaap) family.

Proteomic databases

PaxDbiP0AAD2.
PRIDEiP0AAD2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76195; AAC76195; b3161.
BAE77207; BAE77207; BAE77207.
GeneIDi947675.
KEGGiecj:JW3130.
eco:b3161.
PATRICi32121740. VBIEscCol129921_3256.

Organism-specific databases

EchoBASEiEB0612.
EcoGeneiEG10617. mtr.

Phylogenomic databases

eggNOGiENOG4105CIC. Bacteria.
COG0814. LUCA.
HOGENOMiHOG000269674.
InParanoidiP0AAD2.
KOiK03835.
OMAiIWLLGTM.
PhylomeDBiP0AAD2.

Enzyme and pathway databases

BioCyciEcoCyc:MTR-MONOMER.
ECOL316407:JW3130-MONOMER.
MetaCyc:MTR-MONOMER.

Miscellaneous databases

PROiP0AAD2.

Family and domain databases

InterProiIPR002091. ArAA_permease.
IPR013061. Trp/try_permease_CS.
IPR013059. Trp_tyr_transpt.
IPR018227. Tryptophan/tyrosine_permease.
[Graphical view]
PfamiPF03222. Trp_Tyr_perm. 1 hit.
[Graphical view]
PRINTSiPR00166. AROAAPRMEASE.
TIGRFAMsiTIGR00837. araaP. 1 hit.
PROSITEiPS00594. AROMATIC_AA_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTR_ECOLI
AccessioniPrimary (citable) accession number: P0AAD2
Secondary accession number(s): P22306, Q2M949
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.