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Protein

Modulator of FtsH protease YccA

Gene

yccA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negatively modulates the activity of the FtsH protease for membrane substrates. Overexpression or stabilizing YccA counteracts the FtsH-mediated degradation of SecY when the SecYEG preprotein translocator is jammed.1 Publication

GO - Biological processi

  • negative regulation of apoptotic process Source: InterPro
  • regulation of proteolysis Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:EG11113-MONOMER

Protein family/group databases

TCDBi1.A.14.2.1 the calcium transporter a (cata) (formerly the testis-enhanced gene transfer (tegt) family

Names & Taxonomyi

Protein namesi
Recommended name:
Modulator of FtsH protease YccA
Gene namesi
Name:yccA
Ordered Locus Names:b0970, JW0953
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11113 yccA

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicCuratedAdd BLAST22
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Topological domaini44 – 46ExtracellularCurated3
Transmembranei47 – 64HelicalSequence analysisAdd BLAST18
Topological domaini65 – 73CytoplasmicCurated9
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Topological domaini95 – 104ExtracellularCurated10
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 132CytoplasmicCurated7
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Topological domaini154 – 157ExtracellularCurated4
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 195CytoplasmicCuratedAdd BLAST17
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 219Extracellular3

GO - Cellular componenti

  • integral component of membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No effect on SecY degradation.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1 – 12MDRIV…SHDRT → MTMITPSLHDRI: Protein is as sensitive to FtsH degradation as the wild-type. 1 PublicationAdd BLAST12
Mutagenesisi5 – 12Missing in yccA11; increases the half-life of overexpressed SecY, F(0) ATP synthase subunit a and itself in an HflKC-dependent fashion, but has no effect on degradation of cytosolic substrates sigma-32 or the phage lambda cII protein. Partially dominant over the wild-type allele. This protein interacts with but is not degraded by FtsH. 1 Publication8

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001791021 – 219Modulator of FtsH protease YccAAdd BLAST219

Post-translational modificationi

YccA is processively degraded by FtsH; degradation initiates via the approximately 20 residue N-terminal tail in a sequence non-specific manner. The deletion mutant yccA11 is resistant to FtsH-mediated degradation, probably because it is too short to be degraded by FtsH.

Proteomic databases

PaxDbiP0AAC6
PRIDEiP0AAC6

Expressioni

Inductioni

Regulated in a Cpx-dependent fashion.1 Publication

Interactioni

Subunit structurei

Both wild-type and the yccA11 mutant interact with the FtsH/HflKC complex.

Protein-protein interaction databases

BioGridi4260037, 11 interactors
DIPiDIP-47918N
IntActiP0AAC6, 1 interactor
STRINGi316385.ECDH10B_1040

Structurei

3D structure databases

ProteinModelPortaliP0AAC6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BI1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108MN8 Bacteria
COG0670 LUCA
HOGENOMiHOG000060391
InParanoidiP0AAC6
KOiK19416
OMAiPVRQHLK
PhylomeDBiP0AAC6

Family and domain databases

InterProiView protein in InterPro
IPR006213 Bax_inhbtr1_CS
IPR006214 Bax_inhibitor_1-related
PANTHERiPTHR23291 PTHR23291, 1 hit
PfamiView protein in Pfam
PF01027 Bax1-I, 1 hit
PROSITEiView protein in PROSITE
PS01243 BI1, 1 hit

Sequencei

Sequence statusi: Complete.

P0AAC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRIVSSSHD RTSLLSTHKV LRNTYFLLSL TLAFSAITAT ASTVLMLPSP
60 70 80 90 100
GLILTLVGMY GLMFLTYKTA NKPTGIISAF AFTGFLGYIL GPILNTYLSA
110 120 130 140 150
GMGDVIAMAL GGTALVFFCC SAYVLTTRKD MSFLGGMLMA GIVVVLIGMV
160 170 180 190 200
ANIFLQLPAL HLAISAVFIL ISSGAILFET SNIIHGGETN YIRATVSLYV
210
SLYNIFVSLL SILGFASRD
Length:219
Mass (Da):23,363
Last modified:April 1, 1988 - v1
Checksum:i4F787B853042ACD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00547 Genomic DNA Translation: CAA25218.1
U00096 Genomic DNA Translation: AAC74056.1
AP009048 Genomic DNA Translation: BAA35735.1
PIRiS07180
RefSeqiNP_415490.1, NC_000913.3
WP_000375136.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74056; AAC74056; b0970
BAA35735; BAA35735; BAA35735
GeneIDi946016
KEGGiecj:JW0953
eco:b0970
PATRICifig|1411691.4.peg.1303

Similar proteinsi

Entry informationi

Entry nameiYCCA_ECOLI
AccessioniPrimary (citable) accession number: P0AAC6
Secondary accession number(s): P06967
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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