uspE

Functionⁱ

Required for resistance to DNA-damaging agents.1 Publication

GO - Biological processⁱ

bacterial-type flagellum-dependent cell motility
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 16159758
cellular response to hydrogen peroxide
Source: EcoCyc
Inferred from expression patternⁱ
- 20209085
cellular response to UV
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 11849540
single-species biofilm formation
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 20209085

Complete GO annotation...

Enzyme and pathway databases

BioCycⁱ	EcoCyc:EG11246-MONOMER.

BioCycⁱ

EcoCyc:EG11246-MONOMER.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Universal stress protein E
Gene namesⁱ	Name:uspE Synonyms:ydaA Ordered Locus Names:b1333, JW1327
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG11246. uspE.

EcoGeneⁱ

EG11246. uspE.

Subcellular locationⁱ

Cytoplasm By similarity

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000147417	2 – 316	Universal stress protein EAdd BLAST		315

Proteomic databases

EPDⁱ	P0AAC0.
PaxDbⁱ	P0AAC0.
PRIDEⁱ	P0AAC0.

2D gel databases

SWISS-2DPAGEⁱ	P0AAC0.

SWISS-2DPAGEⁱ

P0AAC0.

Expressionⁱ

Inductionⁱ

During growth inhibition caused by the exhaustion of any of a variety of nutrients (carbon, nitrogen, phosphate, sulfate, required amino acid) or by the presence of a variety of toxic agents. Positively regulated by guanosine 3',5'-bisphosphate (ppGpp) and by a RecA/FtsK-dependent regulatory pathway.1 Publication

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	4260143. 13 interactors.
Database of interacting proteins More...DIPⁱ	DIP-48118N.
IntActⁱ	P0AAC0. 1 interactor.
Molecular INTeraction database More...MINTⁱ	MINT-7290918.
STRINGⁱ	511145.b1333.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	6 – 10	Combined sources	5
Helixⁱ	19 – 28	Combined sources	10
Beta strandⁱ	34 – 41	Combined sources	8
Helixⁱ	44 – 46	Combined sources	3
Turnⁱ	49 – 51	Combined sources	3
Helixⁱ	54 – 82	Combined sources	29
Beta strandⁱ	86 – 92	Combined sources	7
Helixⁱ	96 – 107	Combined sources	12
Beta strandⁱ	110 – 117	Combined sources	8
Helixⁱ	129 – 137	Combined sources	9
Beta strandⁱ	142 – 148	Combined sources	7
Beta strandⁱ	156 – 160	Combined sources	5
Helixⁱ	169 – 184	Combined sources	16
Turnⁱ	185 – 187	Combined sources	3
Beta strandⁱ	192 – 198	Combined sources	7
Helixⁱ	215 – 236	Combined sources	22
Beta strandⁱ	243 – 248	Combined sources	6
Helixⁱ	250 – 260	Combined sources	11
Beta strandⁱ	264 – 268	Combined sources	5
Helixⁱ	283 – 290	Combined sources	8
Beta strandⁱ	294 – 298	Combined sources	5

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5CB0	X-ray	3.21	A/B	1-316	[»]
Database of protein disorder More...DisProtⁱ	DP00991.
ProteinModelPortalⁱ	P0AAC0.
SMRⁱ	P0AAC0.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the universal stress protein A family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG4105Q9Y. Bacteria. COG0589. LUCA.
HOGENOMⁱ	HOG000277987.
InParanoidⁱ	P0AAC0.
KEGG Orthology (KO) More...KOⁱ	K14055.
PhylomeDBⁱ	P0AAC0.

Family and domain databases

Gene3Dⁱ	3.40.50.620. 2 hits.
InterProⁱ	View protein in InterPro IPR014729. Rossmann-like_a/b/a_fold. IPR006016. UspA.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00582. Usp. 2 hits.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P0AAC0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAMYQNMLVV IDPNQDDQPA LRRAVYLHQR IGGKIKAFLP IYDFSYEMTT 
        60         70         80         90        100
LLSPDERTAM RQGVISQRTA WIHEQAKYYL NAGVPIEIKV VWHNRPFEAI 
       110        120        130        140        150
IQEVISGGHD LVLKMAHQHD RLEAVIFTPT DWHLLRKCPS PVWMVKDQPW 
       160        170        180        190        200
PEGGKALVAV NLASEEPYHN ALNEKLVKET IELAEQVNHT EVHLVGAYPV 
       210        220        230        240        250
TPINIAIELP EFDPSVYNDA IRGQHLLAMK ALRQKFGINE NMTHVEKGLP 
       260        270        280        290        300
EEVIPDLAEH LQAGIVVLGT VGRTGISAAF LGNTAEQVID HLRCDLLVIK 
       310 
PDQYQTPVEL DDEEDD

Length:316

Mass (Da):35,707

Last modified:January 23, 2007 - v2

Checksum:ⁱF5F416848D452378

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	55	Missing in AAA87982 (PubMed:6292868).Curated		1
Sequence conflictⁱ	59 – 73	AMRQG…TAWIH → RYASGRHQPAYSLDP (PubMed:6292868).CuratedAdd BLAST		15

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U00096 Genomic DNA. Translation: AAC74415.1. AP009048 Genomic DNA. Translation: BAA14926.1. J01608 Genomic DNA. Translation: AAA87982.1.
PIRⁱ	H64882. QQECX.
NCBI Reference Sequences More...RefSeqⁱ	NP_415849.1. NC_000913.3. WP_001262123.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaⁱ	AAC74415; AAC74415; b1333. BAA14926; BAA14926; BAA14926.
GeneIDⁱ	945904.
KEGGⁱ	ecj:JW1327. eco:b1333.
PATRICⁱ	fig\|1411691.4.peg.944.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U00096 Genomic DNA. Translation: AAC74415.1. AP009048 Genomic DNA. Translation: BAA14926.1. J01608 Genomic DNA. Translation: AAA87982.1.
PIRⁱ	H64882. QQECX.
NCBI Reference Sequences More...RefSeqⁱ	NP_415849.1. NC_000913.3. WP_001262123.1. NZ_LN832404.1.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5CB0	X-ray	3.21	A/B	1-316	[»]
Database of protein disorder More...DisProtⁱ	DP00991.
ProteinModelPortalⁱ	P0AAC0.
SMRⁱ	P0AAC0.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4260143. 13 interactors.
Database of interacting proteins More...DIPⁱ	DIP-48118N.
IntActⁱ	P0AAC0. 1 interactor.
Molecular INTeraction database More...MINTⁱ	MINT-7290918.
STRINGⁱ	511145.b1333.

2D gel databases

SWISS-2DPAGEⁱ	P0AAC0.

SWISS-2DPAGEⁱ

P0AAC0.

Proteomic databases

EPDⁱ	P0AAC0.
PaxDbⁱ	P0AAC0.
PRIDEⁱ	P0AAC0.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC74415; AAC74415; b1333. BAA14926; BAA14926; BAA14926.
GeneIDⁱ	945904.
KEGGⁱ	ecj:JW1327. eco:b1333.
PATRICⁱ	fig\|1411691.4.peg.944.

Organism-specific databases

EchoBASEⁱ	EB1227.
EcoGeneⁱ	EG11246. uspE.

Phylogenomic databases

eggNOGⁱ	ENOG4105Q9Y. Bacteria. COG0589. LUCA.
HOGENOMⁱ	HOG000277987.
InParanoidⁱ	P0AAC0.
KEGG Orthology (KO) More...KOⁱ	K14055.
PhylomeDBⁱ	P0AAC0.

Enzyme and pathway databases

BioCycⁱ	EcoCyc:EG11246-MONOMER.

BioCycⁱ

EcoCyc:EG11246-MONOMER.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P0AAC0.

PROⁱ

PR:P0AAC0.

Family and domain databases

Gene3Dⁱ	3.40.50.620. 2 hits.
InterProⁱ	View protein in InterPro IPR014729. Rossmann-like_a/b/a_fold. IPR006016. UspA.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00582. Usp. 2 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	USPE_ECOLI
Accessionⁱ	P0AAC0Primary (citable) accession number: P0AAC0 Secondary accession number(s): P03807, P77421
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	January 23, 2007
	Last modified:	June 7, 2017
	This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0AAC0 (USPE_ECOLI)

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Universal stress protein E

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

2D gel databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ