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Protein

Universal stress protein E

Gene

uspE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for resistance to DNA-damaging agents.1 Publication

GO - Biological processi

  • bacterial-type flagellum-dependent cell motility Source: EcoCyc
  • cellular response to hydrogen peroxide Source: EcoCyc
  • cellular response to UV Source: EcoCyc
  • single-species biofilm formation Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG11246-MONOMER.
ECOL316407:JW1327-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Universal stress protein E
Gene namesi
Name:uspE
Synonyms:ydaA
Ordered Locus Names:b1333, JW1327
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11246. uspE.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001474172 – 316Universal stress protein EAdd BLAST315

Proteomic databases

EPDiP0AAC0.
PaxDbiP0AAC0.
PRIDEiP0AAC0.

2D gel databases

SWISS-2DPAGEP0AAC0.

Expressioni

Inductioni

During growth inhibition caused by the exhaustion of any of a variety of nutrients (carbon, nitrogen, phosphate, sulfate, required amino acid) or by the presence of a variety of toxic agents. Positively regulated by guanosine 3',5'-bisphosphate (ppGpp) and by a RecA/FtsK-dependent regulatory pathway.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260143. 13 interactors.
DIPiDIP-48118N.
IntActiP0AAC0. 1 interactor.
MINTiMINT-7290918.
STRINGi511145.b1333.

Structurei

Secondary structure

1316
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 10Combined sources5
Helixi19 – 28Combined sources10
Beta strandi34 – 41Combined sources8
Helixi44 – 46Combined sources3
Turni49 – 51Combined sources3
Helixi54 – 82Combined sources29
Beta strandi86 – 92Combined sources7
Helixi96 – 107Combined sources12
Beta strandi110 – 117Combined sources8
Helixi129 – 137Combined sources9
Beta strandi142 – 148Combined sources7
Beta strandi156 – 160Combined sources5
Helixi169 – 184Combined sources16
Turni185 – 187Combined sources3
Beta strandi192 – 198Combined sources7
Helixi215 – 236Combined sources22
Beta strandi243 – 248Combined sources6
Helixi250 – 260Combined sources11
Beta strandi264 – 268Combined sources5
Helixi283 – 290Combined sources8
Beta strandi294 – 298Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CB0X-ray3.21A/B1-316[»]
ProteinModelPortaliP0AAC0.
SMRiP0AAC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the universal stress protein A family.Curated

Phylogenomic databases

eggNOGiENOG4105Q9Y. Bacteria.
COG0589. LUCA.
HOGENOMiHOG000277987.
InParanoidiP0AAC0.
KOiK14055.
OMAiMAKYQNM.
PhylomeDBiP0AAC0.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
InterProiIPR014729. Rossmann-like_a/b/a_fold.
IPR006016. UspA.
[Graphical view]
PfamiPF00582. Usp. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AAC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMYQNMLVV IDPNQDDQPA LRRAVYLHQR IGGKIKAFLP IYDFSYEMTT
60 70 80 90 100
LLSPDERTAM RQGVISQRTA WIHEQAKYYL NAGVPIEIKV VWHNRPFEAI
110 120 130 140 150
IQEVISGGHD LVLKMAHQHD RLEAVIFTPT DWHLLRKCPS PVWMVKDQPW
160 170 180 190 200
PEGGKALVAV NLASEEPYHN ALNEKLVKET IELAEQVNHT EVHLVGAYPV
210 220 230 240 250
TPINIAIELP EFDPSVYNDA IRGQHLLAMK ALRQKFGINE NMTHVEKGLP
260 270 280 290 300
EEVIPDLAEH LQAGIVVLGT VGRTGISAAF LGNTAEQVID HLRCDLLVIK
310
PDQYQTPVEL DDEEDD
Length:316
Mass (Da):35,707
Last modified:January 23, 2007 - v2
Checksum:iF5F416848D452378
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55Missing in AAA87982 (PubMed:6292868).Curated1
Sequence conflicti59 – 73AMRQG…TAWIH → RYASGRHQPAYSLDP (PubMed:6292868).CuratedAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74415.1.
AP009048 Genomic DNA. Translation: BAA14926.1.
J01608 Genomic DNA. Translation: AAA87982.1.
PIRiH64882. QQECX.
RefSeqiNP_415849.1. NC_000913.3.
WP_001262123.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74415; AAC74415; b1333.
BAA14926; BAA14926; BAA14926.
GeneIDi945904.
KEGGiecj:JW1327.
eco:b1333.
PATRICi32117942. VBIEscCol129921_1391.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74415.1.
AP009048 Genomic DNA. Translation: BAA14926.1.
J01608 Genomic DNA. Translation: AAA87982.1.
PIRiH64882. QQECX.
RefSeqiNP_415849.1. NC_000913.3.
WP_001262123.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CB0X-ray3.21A/B1-316[»]
ProteinModelPortaliP0AAC0.
SMRiP0AAC0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260143. 13 interactors.
DIPiDIP-48118N.
IntActiP0AAC0. 1 interactor.
MINTiMINT-7290918.
STRINGi511145.b1333.

2D gel databases

SWISS-2DPAGEP0AAC0.

Proteomic databases

EPDiP0AAC0.
PaxDbiP0AAC0.
PRIDEiP0AAC0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74415; AAC74415; b1333.
BAA14926; BAA14926; BAA14926.
GeneIDi945904.
KEGGiecj:JW1327.
eco:b1333.
PATRICi32117942. VBIEscCol129921_1391.

Organism-specific databases

EchoBASEiEB1227.
EcoGeneiEG11246. uspE.

Phylogenomic databases

eggNOGiENOG4105Q9Y. Bacteria.
COG0589. LUCA.
HOGENOMiHOG000277987.
InParanoidiP0AAC0.
KOiK14055.
OMAiMAKYQNM.
PhylomeDBiP0AAC0.

Enzyme and pathway databases

BioCyciEcoCyc:EG11246-MONOMER.
ECOL316407:JW1327-MONOMER.

Miscellaneous databases

PROiP0AAC0.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
InterProiIPR014729. Rossmann-like_a/b/a_fold.
IPR006016. UspA.
[Graphical view]
PfamiPF00582. Usp. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUSPE_ECOLI
AccessioniPrimary (citable) accession number: P0AAC0
Secondary accession number(s): P03807, P77421
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.