P0AAB8 (USPD_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Universal stress protein D

Gene names

Name:	uspD
Synonyms:	yiiT
Ordered Locus Names:	b3923, JW3894

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Required for resistance to DNA-damaging agents. Ref.4
Subcellular location	Cytoplasm By similarity.
Induction	During growth inhibition caused by the exhaustion of any of a variety of nutrients (carbon, nitrogen, phosphate, sulfate, required amino acid) or by the presence of a variety of toxic agents. Positively regulated by guanosine 3',5'-bisphosphate (ppGpp) and by a RecA/FtsK-dependent regulatory pathway. Ref.4
Sequence similarities	Belongs to the universal stress protein A family.

Ontologies

Keywords
Cellular component	Cytoplasm
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to stress Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 142	142	Universal stress protein D		PRO_0000147413

Sequences

	Sequence		Length	Mass (Da)
	P0AAB8 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 0684CAA0EBE1CF6C	FASTA	142	16,293
	10 20 30 40 50 60 MAYKHIGVAI SGNEEDALLV NKALELARHN DAHLTLIHID DGLSELYPGI YFPATEDILQ 70 80 90 100 110 120 LLKNKSDNKL YKLTKNIQWP KTKLRIERGE MPETLLEIMQ KEQCDLLVCG HHHSFINRLM 130 140 PAYRGMINKM SADLLIVPFI DK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes." Plunkett G. III, Burland V., Daniels D.L., Blattner F.R. Nucleic Acids Res. 21:3391-3398(1993) [PubMed: 8346018] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]	"The universal stress protein paralogues of Escherichia coli are co-ordinately regulated and co-operate in the defence against DNA damage." Gustavsson N., Diez A., Nystroem T. Mol. Microbiol. 43:107-117(2002) [PubMed: 11849540] [Abstract] Cited for: FUNCTION, GENE NAME, TRANSCRIPTIONAL REGULATION. Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L19201 Genomic DNA. Translation: AAB03055.1. U00096 Genomic DNA. Translation: AAC76905.1. AP009048 Genomic DNA. Translation: BAE77387.1.
PIR	S40866.
RefSeq	NP_418358.1. NC_000913.2.
3D structure databases
ProteinModelPortal	P0AAB8.
SMR	P0AAB8. Positions 2-141.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-35856N.
IntAct	P0AAB8. 1 interaction.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000000001; EBESCP00000000001; EBESCG00000000001. EBESCT00000014673; EBESCP00000013964; EBESCG00000013734.
GeneID	948415.
GenomeReviews	Gene locus JW3894 in contig AP009048_GR. Gene locus b3923 in contig U00096_GR.
KEGG	ecj:JW3894. eco:b3923.
PATRIC	32123359. VBIEscCol129921_4040.
Organism-specific databases
EchoBASE	EB1823.
EcoGene	EG11877. uspD.
Phylogenomic databases
eggNOG	COG0589.
GeneTree	EBGT00050000009429.
HOGENOM	HBG733992.
OMA	LADECDY.
PhylomeDB	P0AAB8.
ProtClustDB	PRK09982.
Enzyme and pathway databases
BioCyc	EcoCyc:EG11877-MONOMER.
Gene expression databases
Genevestigator	P0AAB8.
Family and domain databases
InterPro	IPR014729. Rossmann-like_a/b/a_fold. IPR006016. UspA. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K14065.
Pfam	PF00582. Usp. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

USPD_ECOLI

Accession

Primary (citable) accession number: P0AAB8
Secondary accession number(s): P32163, Q2M8L9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program