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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

galF

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Pathwayi: nucleotide-sugar metabolism

This protein is involved in the pathway nucleotide-sugar metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway nucleotide-sugar metabolism and in Carbohydrate metabolism.

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processLipopolysaccharide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00030
UPA00215

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Uridine diphosphoglucose pyrophosphorylase
Gene namesi
Name:galF
Synonyms:wcaN
Ordered Locus Names:Z3205, ECs2846
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002013501 – 297UTP--glucose-1-phosphate uridylyltransferaseAdd BLAST297

Interactioni

Protein-protein interaction databases

STRINGi155864.Z3205

Structurei

3D structure databases

ProteinModelPortaliP0AAB7
SMRiP0AAB7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 2 family.Curated

Phylogenomic databases

eggNOGiENOG4105C3Y Bacteria
COG1210 LUCA
HOGENOMiHOG000283477
KOiK00963
OMAiDECSFSY

Family and domain databases

CDDicd02541 UGPase_prokaryotic, 1 hit
Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR005774 GalF
IPR005771 GalU_uridylyltTrfase_bac/arc
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR43197 PTHR43197, 1 hit
PfamiView protein in Pfam
PF00483 NTP_transferase, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR01105 galF, 1 hit

Sequencei

Sequence statusi: Complete.

P0AAB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNLKAVIPV AGLGMHMLPA TKAIPKEMLP IVDKPMIQYI VDEIVAAGIK
60 70 80 90 100
EILLVTHASK NAVENHFDTS YELESLLEQR VKRQLLAEVQ SICPPGVTIM
110 120 130 140 150
NVRQGEPLGL GHSILCARPA IGDNPFVVVL PDVVIDDASA DPLRYNLAAM
160 170 180 190 200
IARFNETGRS QVLAKRMPGD LSEYSVIQTK EPLDREGKVS RIVEFIEKPD
210 220 230 240 250
QPQTLDSDIM AVGRYVLSAD IWPELERTQP GAWGRIQLTD AIAELAKKQS
260 270 280 290
VDAMLMTGDS YDCGKKMGYM QAFVKYGLRN LKEGAKFRKG IEKLLSE
Length:297
Mass (Da):32,829
Last modified:September 13, 2005 - v1
Checksum:i6F85D6BB12C0C5A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG57101.1
BA000007 Genomic DNA Translation: BAB36269.1
PIRiA85830
F90984
RefSeqiNP_310873.1, NC_002695.1
WP_000183060.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG57101; AAG57101; Z3205
BAB36269; BAB36269; BAB36269
GeneIDi914113
KEGGiece:Z3205
ecs:ECs2846
PATRICifig|386585.9.peg.2979

Similar proteinsi

Entry informationi

Entry nameiGALF_ECO57
AccessioniPrimary (citable) accession number: P0AAB7
Secondary accession number(s): P71245, P78083, P97192
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: April 25, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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