Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

galF

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Pathway:inucleotide-sugar metabolism

This protein is involved in the pathway nucleotide-sugar metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway nucleotide-sugar metabolism and in Carbohydrate metabolism.

Pathway:ilipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciECOL386585:GJFA-2809-MONOMER.
ECOO157:GALF-MONOMER.
UniPathwayiUPA00030.
UPA00215.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Uridine diphosphoglucose pyrophosphorylase
Gene namesi
Name:galF
Synonyms:wcaN
Ordered Locus Names:Z3205, ECs2846
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558 Componenti: Chromosome UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297UTP--glucose-1-phosphate uridylyltransferasePRO_0000201350Add
BLAST

Proteomic databases

PRIDEiP0AAB7.

Interactioni

Protein-protein interaction databases

STRINGi155864.Z3205.

Structurei

3D structure databases

ProteinModelPortaliP0AAB7.
SMRiP0AAB7. Positions 5-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 2 family.Curated

Phylogenomic databases

eggNOGiCOG1210.
HOGENOMiHOG000283477.
KOiK00963.
OMAiDYSYELE.
OrthoDBiEOG6Z9B3V.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005774. GalF.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01105. galF. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AAB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNLKAVIPV AGLGMHMLPA TKAIPKEMLP IVDKPMIQYI VDEIVAAGIK
60 70 80 90 100
EILLVTHASK NAVENHFDTS YELESLLEQR VKRQLLAEVQ SICPPGVTIM
110 120 130 140 150
NVRQGEPLGL GHSILCARPA IGDNPFVVVL PDVVIDDASA DPLRYNLAAM
160 170 180 190 200
IARFNETGRS QVLAKRMPGD LSEYSVIQTK EPLDREGKVS RIVEFIEKPD
210 220 230 240 250
QPQTLDSDIM AVGRYVLSAD IWPELERTQP GAWGRIQLTD AIAELAKKQS
260 270 280 290
VDAMLMTGDS YDCGKKMGYM QAFVKYGLRN LKEGAKFRKG IEKLLSE
Length:297
Mass (Da):32,829
Last modified:September 13, 2005 - v1
Checksum:i6F85D6BB12C0C5A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57101.1.
BA000007 Genomic DNA. Translation: BAB36269.1.
PIRiA85830.
F90984.
RefSeqiNP_310873.1. NC_002695.1.
WP_000183060.1. NZ_LAZD01000262.1.

Genome annotation databases

EnsemblBacteriaiAAG57101; AAG57101; Z3205.
BAB36269; BAB36269; BAB36269.
GeneIDi914113.
KEGGiecs:ECs2846.
PATRICi18355076. VBIEscCol44059_2739.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57101.1.
BA000007 Genomic DNA. Translation: BAB36269.1.
PIRiA85830.
F90984.
RefSeqiNP_310873.1. NC_002695.1.
WP_000183060.1. NZ_LAZD01000262.1.

3D structure databases

ProteinModelPortaliP0AAB7.
SMRiP0AAB7. Positions 5-293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z3205.

Proteomic databases

PRIDEiP0AAB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG57101; AAG57101; Z3205.
BAB36269; BAB36269; BAB36269.
GeneIDi914113.
KEGGiecs:ECs2846.
PATRICi18355076. VBIEscCol44059_2739.

Phylogenomic databases

eggNOGiCOG1210.
HOGENOMiHOG000283477.
KOiK00963.
OMAiDYSYELE.
OrthoDBiEOG6Z9B3V.

Enzyme and pathway databases

UniPathwayiUPA00030.
UPA00215.
BioCyciECOL386585:GJFA-2809-MONOMER.
ECOO157:GALF-MONOMER.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005774. GalF.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01105. galF. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiGALF_ECO57
AccessioniPrimary (citable) accession number: P0AAB7
Secondary accession number(s): P71245, P78083, P97192
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: July 22, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.