ID GALF_ECOLI Reviewed; 297 AA. AC P0AAB6; P71245; P78083; P97192; DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot. DT 13-SEP-2005, sequence version 1. DT 24-JAN-2024, entry version 118. DE RecName: Full=UTP--glucose-1-phosphate uridylyltransferase; DE EC=2.7.7.9; DE AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase; DE AltName: Full=UDP-glucose pyrophosphorylase; DE Short=UDPGP; DE AltName: Full=Uridine diphosphoglucose pyrophosphorylase; GN Name=galF; Synonyms=wcaN; OrderedLocusNames=b2042, JW2027; OS Escherichia coli (strain K12). OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=83333; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX PubMed=9097040; DOI=10.1093/dnares/3.6.379; RA Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., RA Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., RA Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y., RA Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y., RA Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y., RA Horiuchi T.; RT "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to RT the 40.1-50.0 min region on the linkage map."; RL DNA Res. 3:379-392(1996). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / MG1655 / ATCC 47076; RX PubMed=9278503; DOI=10.1126/science.277.5331.1453; RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., RA Shao Y.; RT "The complete genome sequence of Escherichia coli K-12."; RL Science 277:1453-1462(1997). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX PubMed=16738553; DOI=10.1038/msb4100049; RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.; RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 RT and W3110."; RL Mol. Syst. Biol. 2:E1-E5(2006). RN [4] RP CHARACTERIZATION. RX PubMed=8971705; DOI=10.1046/j.1365-2958.1996.01531.x; RA Marolda C.L., Valvano M.A.; RT "The GalF protein of Escherichia coli is not a UDP-glucose RT pyrophosphorylase but interacts with the GalU protein possibly to regulate RT cellular levels of UDP-glucose."; RL Mol. Microbiol. 22:827-840(1996). CC -!- CATALYTIC ACTIVITY: CC Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP- CC alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601, CC ChEBI:CHEBI:58885; EC=2.7.7.9; CC -!- PATHWAY: Carbohydrate metabolism; nucleotide-sugar metabolism. CC -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide CC biosynthesis. CC -!- SIMILARITY: Belongs to the UDPGP type 2 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U38473; AAC77853.1; -; Genomic_DNA. DR EMBL; U00096; AAC75103.1; -; Genomic_DNA. DR EMBL; AP009048; BAA15896.1; -; Genomic_DNA. DR PIR; A64970; A64970. DR RefSeq; NP_416546.1; NC_000913.3. DR RefSeq; WP_000183060.1; NZ_STEB01000002.1. DR AlphaFoldDB; P0AAB6; -. DR SMR; P0AAB6; -. DR BioGRID; 4259678; 180. DR DIP; DIP-35871N; -. DR IntAct; P0AAB6; 17. DR STRING; 511145.b2042; -. DR jPOST; P0AAB6; -. DR PaxDb; 511145-b2042; -. DR EnsemblBacteria; AAC75103; AAC75103; b2042. DR GeneID; 66674061; -. DR GeneID; 946560; -. DR KEGG; ecj:JW2027; -. DR KEGG; eco:b2042; -. DR PATRIC; fig|511145.12.peg.2119; -. DR EchoBASE; EB3348; -. DR eggNOG; COG1210; Bacteria. DR HOGENOM; CLU_029499_1_1_6; -. DR InParanoid; P0AAB6; -. DR OMA; MHYVRQG; -. DR OrthoDB; 9803306at2; -. DR PhylomeDB; P0AAB6; -. DR BioCyc; EcoCyc:G7093-MONOMER; -. DR SABIO-RK; P0AAB6; -. DR UniPathway; UPA00030; -. DR UniPathway; UPA00215; -. DR PRO; PR:P0AAB6; -. DR Proteomes; UP000000318; Chromosome. DR Proteomes; UP000000625; Chromosome. DR GO; GO:0005829; C:cytosol; IDA:EcoCyc. DR GO; GO:0030234; F:enzyme regulator activity; IEA:InterPro. DR GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IDA:EcoCyc. DR GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. DR GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro. DR CDD; cd02541; UGPase_prokaryotic; 1. DR InterPro; IPR005774; GalF. DR InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc. DR InterPro; IPR005835; NTP_transferase_dom. DR InterPro; IPR029044; Nucleotide-diphossugar_trans. DR NCBIfam; TIGR01105; galF; 1. DR PANTHER; PTHR43197; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1. DR PANTHER; PTHR43197:SF2; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1. DR Pfam; PF00483; NTP_transferase; 1. DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1. PE 1: Evidence at protein level; KW Lipopolysaccharide biosynthesis; Nucleotidyltransferase; KW Reference proteome; Transferase. FT CHAIN 1..297 FT /note="UTP--glucose-1-phosphate uridylyltransferase" FT /id="PRO_0000201349" SQ SEQUENCE 297 AA; 32829 MW; 6F85D6BB12C0C5A8 CRC64; MTNLKAVIPV AGLGMHMLPA TKAIPKEMLP IVDKPMIQYI VDEIVAAGIK EILLVTHASK NAVENHFDTS YELESLLEQR VKRQLLAEVQ SICPPGVTIM NVRQGEPLGL GHSILCARPA IGDNPFVVVL PDVVIDDASA DPLRYNLAAM IARFNETGRS QVLAKRMPGD LSEYSVIQTK EPLDREGKVS RIVEFIEKPD QPQTLDSDIM AVGRYVLSAD IWPELERTQP GAWGRIQLTD AIAELAKKQS VDAMLMTGDS YDCGKKMGYM QAFVKYGLRN LKEGAKFRKG IEKLLSE //