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P0AAB6

- GALF_ECOLI

UniProt

P0AAB6 - GALF_ECOLI

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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

galF

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Pathwayi

GO - Molecular functioni

  1. enzyme regulator activity Source: InterPro
  2. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
  2. UDP-glucose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciEcoCyc:G7093-MONOMER.
ECOL316407:JW2027-MONOMER.
SABIO-RKP0AAB6.
UniPathwayiUPA00030.
UPA00215.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Uridine diphosphoglucose pyrophosphorylase
Gene namesi
Name:galF
Synonyms:wcaN
Ordered Locus Names:b2042, JW2027
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13578. galF.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297UTP--glucose-1-phosphate uridylyltransferasePRO_0000201349Add
BLAST

Proteomic databases

PaxDbiP0AAB6.
PRIDEiP0AAB6.

Expressioni

Gene expression databases

GenevestigatoriP0AAB6.

Interactioni

Protein-protein interaction databases

DIPiDIP-35871N.
IntActiP0AAB6. 17 interactions.
STRINGi511145.b2042.

Structurei

3D structure databases

ProteinModelPortaliP0AAB6.
SMRiP0AAB6. Positions 5-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 2 family.Curated

Phylogenomic databases

eggNOGiCOG1210.
HOGENOMiHOG000283477.
InParanoidiP0AAB6.
KOiK00963.
OMAiMDEIMTN.
OrthoDBiEOG6Z9B3V.
PhylomeDBiP0AAB6.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005774. GalF.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01105. galF. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AAB6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNLKAVIPV AGLGMHMLPA TKAIPKEMLP IVDKPMIQYI VDEIVAAGIK
60 70 80 90 100
EILLVTHASK NAVENHFDTS YELESLLEQR VKRQLLAEVQ SICPPGVTIM
110 120 130 140 150
NVRQGEPLGL GHSILCARPA IGDNPFVVVL PDVVIDDASA DPLRYNLAAM
160 170 180 190 200
IARFNETGRS QVLAKRMPGD LSEYSVIQTK EPLDREGKVS RIVEFIEKPD
210 220 230 240 250
QPQTLDSDIM AVGRYVLSAD IWPELERTQP GAWGRIQLTD AIAELAKKQS
260 270 280 290
VDAMLMTGDS YDCGKKMGYM QAFVKYGLRN LKEGAKFRKG IEKLLSE
Length:297
Mass (Da):32,829
Last modified:September 13, 2005 - v1
Checksum:i6F85D6BB12C0C5A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38473 Genomic DNA. Translation: AAC77853.1.
U00096 Genomic DNA. Translation: AAC75103.1.
AP009048 Genomic DNA. Translation: BAA15896.1.
PIRiA64970.
RefSeqiNP_416546.1. NC_000913.3.
YP_490284.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC75103; AAC75103; b2042.
BAA15896; BAA15896; BAA15896.
GeneIDi12930684.
946560.
KEGGiecj:Y75_p2005.
eco:b2042.
PATRICi32119417. VBIEscCol129921_2119.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38473 Genomic DNA. Translation: AAC77853.1 .
U00096 Genomic DNA. Translation: AAC75103.1 .
AP009048 Genomic DNA. Translation: BAA15896.1 .
PIRi A64970.
RefSeqi NP_416546.1. NC_000913.3.
YP_490284.1. NC_007779.1.

3D structure databases

ProteinModelPortali P0AAB6.
SMRi P0AAB6. Positions 5-293.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-35871N.
IntActi P0AAB6. 17 interactions.
STRINGi 511145.b2042.

Proteomic databases

PaxDbi P0AAB6.
PRIDEi P0AAB6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC75103 ; AAC75103 ; b2042 .
BAA15896 ; BAA15896 ; BAA15896 .
GeneIDi 12930684.
946560.
KEGGi ecj:Y75_p2005.
eco:b2042.
PATRICi 32119417. VBIEscCol129921_2119.

Organism-specific databases

EchoBASEi EB3348.
EcoGenei EG13578. galF.

Phylogenomic databases

eggNOGi COG1210.
HOGENOMi HOG000283477.
InParanoidi P0AAB6.
KOi K00963.
OMAi MDEIMTN.
OrthoDBi EOG6Z9B3V.
PhylomeDBi P0AAB6.

Enzyme and pathway databases

UniPathwayi UPA00030 .
UPA00215 .
BioCyci EcoCyc:G7093-MONOMER.
ECOL316407:JW2027-MONOMER.
SABIO-RK P0AAB6.

Miscellaneous databases

PROi P0AAB6.

Gene expression databases

Genevestigatori P0AAB6.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR005774. GalF.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF00483. NTP_transferase. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR01105. galF. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "The GalF protein of Escherichia coli is not a UDP-glucose pyrophosphorylase but interacts with the GalU protein possibly to regulate cellular levels of UDP-glucose."
    Marolda C.L., Valvano M.A.
    Mol. Microbiol. 22:827-840(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiGALF_ECOLI
AccessioniPrimary (citable) accession number: P0AAB6
Secondary accession number(s): P71245, P78083, P97192
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3