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P0AAB6

- GALF_ECOLI

UniProt

P0AAB6 - GALF_ECOLI

Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

galF

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

    Pathwayi

    GO - Molecular functioni

    1. enzyme regulator activity Source: InterPro
    2. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
    2. UDP-glucose metabolic process Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Lipopolysaccharide biosynthesis

    Enzyme and pathway databases

    BioCyciEcoCyc:G7093-MONOMER.
    ECOL316407:JW2027-MONOMER.
    SABIO-RKP0AAB6.
    UniPathwayiUPA00030.
    UPA00215.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
    Alternative name(s):
    Alpha-D-glucosyl-1-phosphate uridylyltransferase
    UDP-glucose pyrophosphorylase
    Short name:
    UDPGP
    Uridine diphosphoglucose pyrophosphorylase
    Gene namesi
    Name:galF
    Synonyms:wcaN
    Ordered Locus Names:b2042, JW2027
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG13578. galF.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 297297UTP--glucose-1-phosphate uridylyltransferasePRO_0000201349Add
    BLAST

    Proteomic databases

    PaxDbiP0AAB6.
    PRIDEiP0AAB6.

    Expressioni

    Gene expression databases

    GenevestigatoriP0AAB6.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-35871N.
    IntActiP0AAB6. 17 interactions.
    STRINGi511145.b2042.

    Structurei

    3D structure databases

    ProteinModelPortaliP0AAB6.
    SMRiP0AAB6. Positions 5-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDPGP type 2 family.Curated

    Phylogenomic databases

    eggNOGiCOG1210.
    HOGENOMiHOG000283477.
    KOiK00963.
    OMAiMDEIMTN.
    OrthoDBiEOG6Z9B3V.
    PhylomeDBiP0AAB6.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR005774. GalF.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF00483. NTP_transferase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    TIGRFAMsiTIGR01105. galF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0AAB6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNLKAVIPV AGLGMHMLPA TKAIPKEMLP IVDKPMIQYI VDEIVAAGIK    50
    EILLVTHASK NAVENHFDTS YELESLLEQR VKRQLLAEVQ SICPPGVTIM 100
    NVRQGEPLGL GHSILCARPA IGDNPFVVVL PDVVIDDASA DPLRYNLAAM 150
    IARFNETGRS QVLAKRMPGD LSEYSVIQTK EPLDREGKVS RIVEFIEKPD 200
    QPQTLDSDIM AVGRYVLSAD IWPELERTQP GAWGRIQLTD AIAELAKKQS 250
    VDAMLMTGDS YDCGKKMGYM QAFVKYGLRN LKEGAKFRKG IEKLLSE 297
    Length:297
    Mass (Da):32,829
    Last modified:September 13, 2005 - v1
    Checksum:i6F85D6BB12C0C5A8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U38473 Genomic DNA. Translation: AAC77853.1.
    U00096 Genomic DNA. Translation: AAC75103.1.
    AP009048 Genomic DNA. Translation: BAA15896.1.
    PIRiA64970.
    RefSeqiNP_416546.1. NC_000913.3.
    YP_490284.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC75103; AAC75103; b2042.
    BAA15896; BAA15896; BAA15896.
    GeneIDi12930684.
    946560.
    KEGGiecj:Y75_p2005.
    eco:b2042.
    PATRICi32119417. VBIEscCol129921_2119.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U38473 Genomic DNA. Translation: AAC77853.1 .
    U00096 Genomic DNA. Translation: AAC75103.1 .
    AP009048 Genomic DNA. Translation: BAA15896.1 .
    PIRi A64970.
    RefSeqi NP_416546.1. NC_000913.3.
    YP_490284.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P0AAB6.
    SMRi P0AAB6. Positions 5-293.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-35871N.
    IntActi P0AAB6. 17 interactions.
    STRINGi 511145.b2042.

    Proteomic databases

    PaxDbi P0AAB6.
    PRIDEi P0AAB6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC75103 ; AAC75103 ; b2042 .
    BAA15896 ; BAA15896 ; BAA15896 .
    GeneIDi 12930684.
    946560.
    KEGGi ecj:Y75_p2005.
    eco:b2042.
    PATRICi 32119417. VBIEscCol129921_2119.

    Organism-specific databases

    EchoBASEi EB3348.
    EcoGenei EG13578. galF.

    Phylogenomic databases

    eggNOGi COG1210.
    HOGENOMi HOG000283477.
    KOi K00963.
    OMAi MDEIMTN.
    OrthoDBi EOG6Z9B3V.
    PhylomeDBi P0AAB6.

    Enzyme and pathway databases

    UniPathwayi UPA00030 .
    UPA00215 .
    BioCyci EcoCyc:G7093-MONOMER.
    ECOL316407:JW2027-MONOMER.
    SABIO-RK P0AAB6.

    Miscellaneous databases

    PROi P0AAB6.

    Gene expression databases

    Genevestigatori P0AAB6.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR005774. GalF.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF00483. NTP_transferase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    TIGRFAMsi TIGR01105. galF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    4. "The GalF protein of Escherichia coli is not a UDP-glucose pyrophosphorylase but interacts with the GalU protein possibly to regulate cellular levels of UDP-glucose."
      Marolda C.L., Valvano M.A.
      Mol. Microbiol. 22:827-840(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiGALF_ECOLI
    AccessioniPrimary (citable) accession number: P0AAB6
    Secondary accession number(s): P71245, P78083, P97192
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3