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Protein

Low molecular weight protein-tyrosine-phosphatase Wzb

Gene

wzb

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Dephosphorylates Wzc. Required for the extracellular polysaccharide colanic acid synthesis. Probably involved in the export of colanic acid from the cell to medium. Involved in protection of cells against contact-dependent growth inhibition (CDI).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Pathwayi: exopolysaccharide biosynthesis

This protein is involved in the pathway exopolysaccharide biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway exopolysaccharide biosynthesis and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei9NucleophileBy similarity1
Active sitei14By similarity1
Active sitei115Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Exopolysaccharide synthesis

Enzyme and pathway databases

BioCyciECOO157:WZB-MONOMER.
UniPathwayiUPA00631.

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight protein-tyrosine-phosphatase Wzb (EC:3.1.3.48)
Gene namesi
Name:wzb
Ordered Locus Names:Z3226, ECs2866
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000465731 – 147Low molecular weight protein-tyrosine-phosphatase WzbAdd BLAST147

Interactioni

Protein-protein interaction databases

STRINGi155864.Z3226.

Structurei

3D structure databases

ProteinModelPortaliP0AAB3.
SMRiP0AAB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105KJF. Bacteria.
COG0394. LUCA.
HOGENOMiHOG000273091.
KOiK01104.
OMAiCEIAPEM.

Family and domain databases

CDDicd00115. LMWPc. 1 hit.
InterProiIPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF20. PTHR11717:SF20. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AAB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNNILVVCV GNICRSPTAE RLLQRYHPEL KVESAGLGAL VGKGADPTAI
60 70 80 90 100
SVAAEHQLSL EGHCARQISR RLCRNYDLIL TMEKRHIERL CEMAPEMRGK
110 120 130 140
VMLFGHWDNE CEIPDPYRKS RETFAAVYTL LERSARQWAQ ALNAEQV
Length:147
Mass (Da):16,709
Last modified:September 13, 2005 - v1
Checksum:i6E36D7CE1038133B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57121.1.
BA000007 Genomic DNA. Translation: BAB36289.1.
PIRiB90987.
E85832.
RefSeqiNP_310893.1. NC_002695.1.
WP_000482901.1. NZ_LPWC02000002.1.

Genome annotation databases

EnsemblBacteriaiAAG57121; AAG57121; Z3226.
BAB36289; BAB36289; BAB36289.
GeneIDi913690.
KEGGiece:Z3226.
ecs:ECs2866.
PATRICi18355116. VBIEscCol44059_2759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57121.1.
BA000007 Genomic DNA. Translation: BAB36289.1.
PIRiB90987.
E85832.
RefSeqiNP_310893.1. NC_002695.1.
WP_000482901.1. NZ_LPWC02000002.1.

3D structure databases

ProteinModelPortaliP0AAB3.
SMRiP0AAB3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z3226.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG57121; AAG57121; Z3226.
BAB36289; BAB36289; BAB36289.
GeneIDi913690.
KEGGiece:Z3226.
ecs:ECs2866.
PATRICi18355116. VBIEscCol44059_2759.

Phylogenomic databases

eggNOGiENOG4105KJF. Bacteria.
COG0394. LUCA.
HOGENOMiHOG000273091.
KOiK01104.
OMAiCEIAPEM.

Enzyme and pathway databases

UniPathwayiUPA00631.
BioCyciECOO157:WZB-MONOMER.

Family and domain databases

CDDicd00115. LMWPc. 1 hit.
InterProiIPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF20. PTHR11717:SF20. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiWZB_ECO57
AccessioniPrimary (citable) accession number: P0AAB3
Secondary accession number(s): P77153
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.