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P0AAB2

- WZB_ECOLI

UniProt

P0AAB2 - WZB_ECOLI

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Protein

Low molecular weight protein-tyrosine-phosphatase wzb

Gene

wzb

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Dephosphorylates wzc. Required for the extracellular polysaccharide colanic acid synthesis. Probably involved in the export of colanic acid from the cell to medium.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei9 – 91NucleophileBy similarity
Active sitei14 – 141By similarity
Active sitei115 – 1151Proton donorBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: EcoCyc

GO - Biological processi

  1. colanic acid biosynthetic process Source: EcoCyc
  2. peptidyl-tyrosine dephosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Exopolysaccharide synthesis

Enzyme and pathway databases

BioCyciEcoCyc:G7106-MONOMER.
ECOL316407:JW2046-MONOMER.
MetaCyc:G7106-MONOMER.
UniPathwayiUPA00631.

Protein family/group databases

PptaseDBiP3D0409135.

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight protein-tyrosine-phosphatase wzb (EC:3.1.3.48)
Gene namesi
Name:wzb
Ordered Locus Names:b2061, JW2046
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13567. wzb.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 147147Low molecular weight protein-tyrosine-phosphatase wzbPRO_0000046572Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP0AAB2.

Interactioni

Protein-protein interaction databases

IntActiP0AAB2. 17 interactions.
MINTiMINT-8293227.
STRINGi511145.b2061.

Structurei

Secondary structure

1
147
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 1411Combined sources
Helixi15 – 2612Combined sources
Beta strandi31 – 366Combined sources
Helixi47 – 559Combined sources
Helixi70 – 756Combined sources
Beta strandi76 – 827Combined sources
Helixi84 – 9310Combined sources
Helixi95 – 1006Combined sources
Beta strandi101 – 1033Combined sources
Helixi104 – 1074Combined sources
Turni108 – 1103Combined sources
Helixi121 – 14323Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FEKNMR-A1-147[»]
ProteinModelPortaliP0AAB2.
SMRiP0AAB2. Positions 1-147.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AAB2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0394.
HOGENOMiHOG000273091.
InParanoidiP0AAB2.
KOiK01104.
OMAiCELAPEM.
OrthoDBiEOG63VC26.
PhylomeDBiP0AAB2.

Family and domain databases

InterProiIPR023485. Ptyr_pPase_SF.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF7. PTHR11717:SF7. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AAB2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFNNILVVCV GNICRSPTAE RLLQRYHPEL KVESAGLGAL VGKGADPTAI
60 70 80 90 100
SVAAEHQLSL EGHCARQISR RLCRNYDLIL TMEKRHIERL CEMAPEMRGK
110 120 130 140
VMLFGHWDNE CEIPDPYRKS RETFAAVYTL LERSARQWAQ ALNAEQV
Length:147
Mass (Da):16,709
Last modified:September 13, 2005 - v1
Checksum:i6E36D7CE1038133B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38473 Genomic DNA. Translation: AAC77834.1.
U00096 Genomic DNA. Translation: AAC75122.1.
AP009048 Genomic DNA. Translation: BAE76575.1.
PIRiD64972.
RefSeqiNP_416565.1. NC_000913.3.
YP_490303.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC75122; AAC75122; b2061.
BAE76575; BAE76575; BAE76575.
GeneIDi12931963.
946564.
KEGGiecj:Y75_p2024.
eco:b2061.
PATRICi32119455. VBIEscCol129921_2138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38473 Genomic DNA. Translation: AAC77834.1 .
U00096 Genomic DNA. Translation: AAC75122.1 .
AP009048 Genomic DNA. Translation: BAE76575.1 .
PIRi D64972.
RefSeqi NP_416565.1. NC_000913.3.
YP_490303.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2FEK NMR - A 1-147 [» ]
ProteinModelPortali P0AAB2.
SMRi P0AAB2. Positions 1-147.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P0AAB2. 17 interactions.
MINTi MINT-8293227.
STRINGi 511145.b2061.

Protein family/group databases

PptaseDBi P3D0409135.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC75122 ; AAC75122 ; b2061 .
BAE76575 ; BAE76575 ; BAE76575 .
GeneIDi 12931963.
946564.
KEGGi ecj:Y75_p2024.
eco:b2061.
PATRICi 32119455. VBIEscCol129921_2138.

Organism-specific databases

EchoBASEi EB3337.
EcoGenei EG13567. wzb.

Phylogenomic databases

eggNOGi COG0394.
HOGENOMi HOG000273091.
InParanoidi P0AAB2.
KOi K01104.
OMAi CELAPEM.
OrthoDBi EOG63VC26.
PhylomeDBi P0AAB2.

Enzyme and pathway databases

UniPathwayi UPA00631 .
BioCyci EcoCyc:G7106-MONOMER.
ECOL316407:JW2046-MONOMER.
MetaCyc:G7106-MONOMER.

Miscellaneous databases

EvolutionaryTracei P0AAB2.
PROi P0AAB2.

Gene expression databases

Genevestigatori P0AAB2.

Family and domain databases

InterProi IPR023485. Ptyr_pPase_SF.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view ]
PANTHERi PTHR11717:SF7. PTHR11717:SF7. 1 hit.
Pfami PF01451. LMWPc. 1 hit.
[Graphical view ]
PRINTSi PR00719. LMWPTPASE.
SMARTi SM00226. LMWPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52788. SSF52788. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid."
    Stevenson G., Andrianopoulos K., Hobbs M., Reeves P.R.
    J. Bacteriol. 178:4885-4893(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Cells of Escherichia coli contain a protein-tyrosine kinase, Wzc, and a phosphotyrosine-protein phosphatase, Wzb."
    Vincent C., Doublet P., Grangeasse C., Vaganay E., Cozzone A.J., Duclos B.
    J. Bacteriol. 181:3472-3477(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Strain: K12 / JM109 / ATCC 53323.
  5. "Relationship between exopolysaccharide production and protein-tyrosine phosphorylation in Gram-negative bacteria."
    Vincent C., Duclos B., Grangeasse C., Vaganay E., Riberty M., Cozzone A.J., Doublet P.
    J. Mol. Biol. 304:311-321(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Strain: K12 / JM109 / ATCC 53323.

Entry informationi

Entry nameiWZB_ECOLI
AccessioniPrimary (citable) accession number: P0AAB2
Secondary accession number(s): P77153, Q2MAY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: November 26, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3