Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P0AAB2 (WZB_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Low molecular weight protein-tyrosine-phosphatase wzb

EC=3.1.3.48
Gene names
Name:wzb
Ordered Locus Names:b2061, JW2046
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length147 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Dephosphorylates wzc. Required for the extracellular polysaccharide colanic acid synthesis. Probably involved in the export of colanic acid from the cell to medium.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Pathway

Glycan metabolism; exopolysaccharide biosynthesis.

Sequence similarities

Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 147147Low molecular weight protein-tyrosine-phosphatase wzb
PRO_0000046572

Sites

Active site91Nucleophile By similarity
Active site141 By similarity
Active site1151Proton donor By similarity

Secondary structure

.................... 147
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0AAB2 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 6E36D7CE1038133B

FASTA14716,709
        10         20         30         40         50         60 
MFNNILVVCV GNICRSPTAE RLLQRYHPEL KVESAGLGAL VGKGADPTAI SVAAEHQLSL 

        70         80         90        100        110        120 
EGHCARQISR RLCRNYDLIL TMEKRHIERL CEMAPEMRGK VMLFGHWDNE CEIPDPYRKS 

       130        140 
RETFAAVYTL LERSARQWAQ ALNAEQV 

« Hide

References

« Hide 'large scale' references
[1]"Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid."
Stevenson G., Andrianopoulos K., Hobbs M., Reeves P.R.
J. Bacteriol. 178:4885-4893(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: K12.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"Cells of Escherichia coli contain a protein-tyrosine kinase, Wzc, and a phosphotyrosine-protein phosphatase, Wzb."
Vincent C., Doublet P., Grangeasse C., Vaganay E., Cozzone A.J., Duclos B.
J. Bacteriol. 181:3472-3477(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
Strain: K12 / JM109 / ATCC 53323.
[5]"Relationship between exopolysaccharide production and protein-tyrosine phosphorylation in Gram-negative bacteria."
Vincent C., Duclos B., Grangeasse C., Vaganay E., Riberty M., Cozzone A.J., Doublet P.
J. Mol. Biol. 304:311-321(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
Strain: K12 / JM109 / ATCC 53323.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U38473 Genomic DNA. Translation: AAC77834.1.
U00096 Genomic DNA. Translation: AAC75122.1.
AP009048 Genomic DNA. Translation: BAE76575.1.
PIRD64972.
RefSeqNP_416565.1. NC_000913.3.
YP_490303.1. NC_007779.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2FEKNMR-A1-147[»]
ProteinModelPortalP0AAB2.
SMRP0AAB2. Positions 1-147.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP0AAB2. 17 interactions.
MINTMINT-8293227.
STRING511145.b2061.

Protein family/group databases

PptaseDBP3D0409135.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC75122; AAC75122; b2061.
BAE76575; BAE76575; BAE76575.
GeneID12931963.
946564.
KEGGecj:Y75_p2024.
eco:b2061.
PATRIC32119455. VBIEscCol129921_2138.

Organism-specific databases

EchoBASEEB3337.
EcoGeneEG13567. wzb.

Phylogenomic databases

eggNOGCOG0394.
HOGENOMHOG000273091.
KOK01104.
OMACELAPEM.
OrthoDBEOG63VC26.
PhylomeDBP0AAB2.

Enzyme and pathway databases

BioCycEcoCyc:G7106-MONOMER.
ECOL316407:JW2046-MONOMER.
MetaCyc:G7106-MONOMER.
UniPathwayUPA00631.

Gene expression databases

GenevestigatorP0AAB2.

Family and domain databases

InterProIPR023485. Ptyr_pPase_SF.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERPTHR11717. PTHR11717. 1 hit.
PfamPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSPR00719. LMWPTPASE.
SMARTSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMSSF52788. SSF52788. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP0AAB2.
PROP0AAB2.

Entry information

Entry nameWZB_ECOLI
AccessionPrimary (citable) accession number: P0AAB2
Secondary accession number(s): P77153, Q2MAY1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene