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Protein

Zinc resistance-associated protein

Gene

zraP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds zinc. Could be an important component of the zinc-balancing mechanism.

GO - Molecular functioni

  • zinc ion binding Source: EcoCyc
Complete GO annotation...

Keywords - Ligandi

Zinc

Enzyme and pathway databases

BioCyciEcoCyc:EG11918-MONOMER.
ECOL316407:JW5546-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc resistance-associated protein
Gene namesi
Name:zraP
Synonyms:yjaI, zra
Ordered Locus Names:b4002, JW5546
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11918. zraP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26261 PublicationAdd
BLAST
Chaini27 – 141115Zinc resistance-associated proteinPRO_0000022720Add
BLAST

Proteomic databases

PaxDbiP0AAA9.

Interactioni

Protein-protein interaction databases

BioGridi4259525. 8 interactions.
STRINGi511145.b4002.

Structurei

3D structure databases

ProteinModelPortaliP0AAA9.
SMRiP0AAA9. Positions 39-119.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZraP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105JBU. Bacteria.
COG3678. LUCA.
HOGENOMiHOG000126776.
KOiK07803.
OMAiGMGYGDC.
OrthoDBiEOG60W828.

Family and domain databases

InterProiIPR025961. Metal_resist.
IPR020365. Zn_resistance-assoc_prot_ZraP.
[Graphical view]
PfamiPF13801. Metal_resist. 1 hit.
[Graphical view]
ProDomiPD097062. Zn_resistance-assoc_prot_ZraP. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AAA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRNTKIALV MMALSAMAMG STSAFAHGGH GMWQQNAAPL TSEQQTAWQK
60 70 80 90 100
IHNDFYAQSS ALQQQLVTKR YEYNALLAAN PPDSSKINAV AKEMENLRQS
110 120 130 140
LDELRVKRDI AMAEAGIPRG AGMGMGYGGC GGGGHMGMGH W
Length:141
Mass (Da):15,199
Last modified:September 13, 2005 - v1
Checksum:i392A8B29CEBECC1B
GO

Sequence cautioni

The sequence AAC43100.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00006 Genomic DNA. Translation: AAC43100.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76976.2.
AP009048 Genomic DNA. Translation: BAE77317.1.
PIRiE65207.
RefSeqiNP_418430.2. NC_000913.3.
WP_000828222.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76976; AAC76976; b4002.
BAE77317; BAE77317; BAE77317.
GeneIDi948507.
KEGGiecj:JW5546.
eco:b4002.
PATRICi32123527. VBIEscCol129921_4116.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00006 Genomic DNA. Translation: AAC43100.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76976.2.
AP009048 Genomic DNA. Translation: BAE77317.1.
PIRiE65207.
RefSeqiNP_418430.2. NC_000913.3.
WP_000828222.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AAA9.
SMRiP0AAA9. Positions 39-119.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259525. 8 interactions.
STRINGi511145.b4002.

Proteomic databases

PaxDbiP0AAA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76976; AAC76976; b4002.
BAE77317; BAE77317; BAE77317.
GeneIDi948507.
KEGGiecj:JW5546.
eco:b4002.
PATRICi32123527. VBIEscCol129921_4116.

Organism-specific databases

EchoBASEiEB1862.
EcoGeneiEG11918. zraP.

Phylogenomic databases

eggNOGiENOG4105JBU. Bacteria.
COG3678. LUCA.
HOGENOMiHOG000126776.
KOiK07803.
OMAiGMGYGDC.
OrthoDBiEOG60W828.

Enzyme and pathway databases

BioCyciEcoCyc:EG11918-MONOMER.
ECOL316407:JW5546-MONOMER.

Miscellaneous databases

PROiP0AAA9.

Family and domain databases

InterProiIPR025961. Metal_resist.
IPR020365. Zn_resistance-assoc_prot_ZraP.
[Graphical view]
PfamiPF13801. Metal_resist. 1 hit.
[Graphical view]
ProDomiPD097062. Zn_resistance-assoc_prot_ZraP. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes."
    Blattner F.R., Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L.
    Nucleic Acids Res. 21:5408-5417(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Identification of a novel transcription regulator from Proteus mirabilis, PMTR, revealed a possible role of YJAI protein in balancing zinc in Escherichia coli."
    Noll M., Petrukhin K., Lutsenko S.
    J. Biol. Chem. 273:21393-21401(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-41, CHARACTERIZATION.

Entry informationi

Entry nameiZRAP_ECOLI
AccessioniPrimary (citable) accession number: P0AAA9
Secondary accession number(s): P32682, Q2M8T9, Q8X6X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: January 20, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.