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Protein

Common pilus major fimbrillin subunit EcpA

Gene

ecpA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition. Major subunit of the fimbria (By similarity).By similarity

Miscellaneous

Not expressed under classical laboratory conditions, but is functional when constitutively expressed (PubMed:11466275 and PubMed:20522494).

Enzyme and pathway databases

BioCyciEcoCyc:G6164-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Common pilus major fimbrillin subunit EcpA
Alternative name(s):
MatB fimbrillin
Gene namesi
Name:ecpA
Synonyms:matB, yagZ
Ordered Locus Names:b0293, JW0287
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13565 ecpA

Subcellular locationi

GO - Cellular componenti

  • pilus Source: UniProtKB-SubCell

Keywords - Cellular componenti

Fimbrium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001379023 – 195Common pilus major fimbrillin subunit EcpAAdd BLAST173

Proteomic databases

PaxDbiP0AAA3
PRIDEiP0AAA3

Expressioni

Inductioni

Negatively regulated by H-NS. Positively regulated by IHF and EcpR (By similarity).By similarity

Interactioni

Subunit structurei

Self-associates. Forms filaments. Interacts with EcpD (By similarity).By similarity

Protein-protein interaction databases

BioGridi4259792, 22 interactors
STRINGi316385.ECDH10B_0281

Structurei

3D structure databases

ProteinModelPortaliP0AAA3
SMRiP0AAA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EcpA/MatB fimbrillin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108GWT Bacteria
ENOG410ZQ0F LUCA
HOGENOMiHOG000269503
KOiK21964
OMAiQDQFTFT

Family and domain databases

Gene3Di2.60.40.3290, 1 hit
InterProiView protein in InterPro
IPR016514 EcpA
IPR038478 Fimbrillin_EcpA_sf
PfamiView protein in Pfam
PF16449 MatB, 1 hit
PIRSFiPIRSF007320 Fimbrillin_MatB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AAA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKVLAIAL VTVFTGMGVA QAADVTAQAV ATWSATAKKD TTSKLVVTPL
60 70 80 90 100
GSLAFQYAEG IKGFNSQKGL FDVAIEGDST ATAFKLTSRL ITNTLTQLDT
110 120 130 140 150
SGSTLNVGVD YNGAAVEKTG DTVMIDTANG VLGGNLSPLA NGYNASNRTT
160 170 180 190
AQDGFTFSII SGTTNGTTAV TDYSTLPEGI WSGDVSVQFD ATWTS
Length:195
Mass (Da):20,111
Last modified:September 13, 2005 - v1
Checksum:i60791615380A2A44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA Translation: AAB18022.1
U00096 Genomic DNA Translation: AAC73396.1
AP009048 Genomic DNA Translation: BAE76077.1
PIRiE64755
RefSeqiNP_414827.1, NC_000913.3
WP_000730972.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73396; AAC73396; b0293
BAE76077; BAE76077; BAE76077
GeneIDi948759
KEGGiecj:JW0287
eco:b0293
PATRICifig|1411691.4.peg.1985

Similar proteinsi

Entry informationi

Entry nameiECPA_ECOLI
AccessioniPrimary (citable) accession number: P0AAA3
Secondary accession number(s): P77264, Q2MCC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: March 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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