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Protein

Common pilus major fimbrillin subunit EcpA

Gene

ecpA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition. Major subunit of the fimbria (By similarity).By similarity

Enzyme and pathway databases

BioCyciEcoCyc:G6164-MONOMER.
ECOL316407:JW0287-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Common pilus major fimbrillin subunit EcpA
Alternative name(s):
MatB fimbrillin
Gene namesi
Name:ecpA
Synonyms:matB, yagZ
Ordered Locus Names:b0293, JW0287
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13565. ecpA.

Subcellular locationi

GO - Cellular componenti

  • pilus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Fimbrium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 195173Common pilus major fimbrillin subunit EcpAPRO_0000013790Add
BLAST

Proteomic databases

PaxDbiP0AAA3.

Expressioni

Inductioni

Negatively regulated by H-NS. Positively regulated by IHF and EcpR (By similarity).By similarity

Interactioni

Subunit structurei

Self-associates. Forms filaments. Interacts with EcpD (By similarity).By similarity

Protein-protein interaction databases

BioGridi4259792. 22 interactions.
STRINGi511145.b0293.

Structurei

3D structure databases

ProteinModelPortaliP0AAA3.
SMRiP0AAA3. Positions 23-195.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EcpA/MatB fimbrillin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108GWT. Bacteria.
ENOG410ZQ0F. LUCA.
HOGENOMiHOG000269503.
OMAiATWKATA.

Family and domain databases

InterProiIPR016514. MatB.
[Graphical view]
PfamiPF16449. MatB. 1 hit.
[Graphical view]
PIRSFiPIRSF007320. Fimbrillin_MatB. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AAA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKVLAIAL VTVFTGMGVA QAADVTAQAV ATWSATAKKD TTSKLVVTPL
60 70 80 90 100
GSLAFQYAEG IKGFNSQKGL FDVAIEGDST ATAFKLTSRL ITNTLTQLDT
110 120 130 140 150
SGSTLNVGVD YNGAAVEKTG DTVMIDTANG VLGGNLSPLA NGYNASNRTT
160 170 180 190
AQDGFTFSII SGTTNGTTAV TDYSTLPEGI WSGDVSVQFD ATWTS
Length:195
Mass (Da):20,111
Last modified:September 13, 2005 - v1
Checksum:i60791615380A2A44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA. Translation: AAB18022.1.
U00096 Genomic DNA. Translation: AAC73396.1.
AP009048 Genomic DNA. Translation: BAE76077.1.
PIRiE64755.
RefSeqiNP_414827.1. NC_000913.3.
WP_000730972.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73396; AAC73396; b0293.
BAE76077; BAE76077; BAE76077.
GeneIDi948759.
KEGGiecj:JW0287.
eco:b0293.
PATRICi32115709. VBIEscCol129921_0297.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA. Translation: AAB18022.1.
U00096 Genomic DNA. Translation: AAC73396.1.
AP009048 Genomic DNA. Translation: BAE76077.1.
PIRiE64755.
RefSeqiNP_414827.1. NC_000913.3.
WP_000730972.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AAA3.
SMRiP0AAA3. Positions 23-195.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259792. 22 interactions.
STRINGi511145.b0293.

Proteomic databases

PaxDbiP0AAA3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73396; AAC73396; b0293.
BAE76077; BAE76077; BAE76077.
GeneIDi948759.
KEGGiecj:JW0287.
eco:b0293.
PATRICi32115709. VBIEscCol129921_0297.

Organism-specific databases

EchoBASEiEB3335.
EcoGeneiEG13565. ecpA.

Phylogenomic databases

eggNOGiENOG4108GWT. Bacteria.
ENOG410ZQ0F. LUCA.
HOGENOMiHOG000269503.
OMAiATWKATA.

Enzyme and pathway databases

BioCyciEcoCyc:G6164-MONOMER.
ECOL316407:JW0287-MONOMER.

Miscellaneous databases

PROiP0AAA3.

Family and domain databases

InterProiIPR016514. MatB.
[Graphical view]
PfamiPF16449. MatB. 1 hit.
[Graphical view]
PIRSFiPIRSF007320. Fimbrillin_MatB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiECPA_ECOLI
AccessioniPrimary (citable) accession number: P0AAA3
Secondary accession number(s): P77264, Q2MCC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Not expressed under classical laboratory conditions, but is functional when constitutively expressed (PubMed:11466275 and PubMed:20522494).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.