Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cardiolipin synthase B

Gene

clsB

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei113UniRule annotation1
Active sitei115UniRule annotation1
Active sitei120UniRule annotation1
Active sitei290UniRule annotation1
Active sitei292UniRule annotation1
Active sitei297UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase BUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:clsBUniRule annotation
Synonyms:ybhO
Ordered Locus Names:Z1008, ECs0867
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002012841 – 413Cardiolipin synthase BAdd BLAST413

Interactioni

Protein-protein interaction databases

STRINGi155864.Z1008

Structurei

3D structure databases

ProteinModelPortaliP0AA85
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 135PLD phosphodiesterase 1UniRule annotationAdd BLAST28
Domaini285 – 312PLD phosphodiesterase 2UniRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsB sub-subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105DZQ Bacteria
COG1502 LUCA
HOGENOMiHOG000264393
KOiK06131
OMAiVLFLQMW

Family and domain databases

HAMAPiMF_01917 Cardiolipin_synth_ClsB, 1 hit
InterProiView protein in InterPro
IPR030872 Cardiolipin_synth_ClsB
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13091 PLDc_2, 2 hits
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

P0AA85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCSWREGNK IQLLENGEQY YPAVFKAIGE AQERIILETF IWFEDDVGKQ
60 70 80 90 100
LHAALLAAAQ RGVKAEVLLD GYGSPDLSDE FVNELTAAGV VFRYYDPRPR
110 120 130 140 150
LFGMRTNVFR RMHRKIVVID ARIAFIGGLN YSAEHMSSYG PEAKQDYAVR
160 170 180 190 200
LEGPIVEDIL QFELENLPGQ SAARRWWRRH HKAEENRQPG EAQVLLVWRD
210 220 230 240 250
NEEHRDDIER HYLKMLTQAR REVIIANAYF FPGYRFLHAL RKAARRGVRI
260 270 280 290 300
KLIIQGEPDM PIVRVGARLL YNYLVKGGVQ VFEYRRRPLH GKVALMDDHW
310 320 330 340 350
ATVGSSNLDP LSLSLNLEAN VIIHDRHFNQ TLRDNLNGII AADCQQVDET
360 370 380 390 400
MLPKRTWWNL TKSVLAFHFL RHFPALVGWL PAHTPRLAQV DPPAQPTMET
410
QDRVETENTG VKP
Length:413
Mass (Da):47,634
Last modified:September 13, 2005 - v1
Checksum:i74998B2A1AD24A11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG55160.1
BA000007 Genomic DNA Translation: BAB34290.1
PIRiC90737
D85587
RefSeqiNP_308894.1, NC_002695.1
WP_000650337.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG55160; AAG55160; Z1008
BAB34290; BAB34290; BAB34290
GeneIDi917609
KEGGiece:Z1008
ecs:ECs0867
PATRICifig|386585.9.peg.981

Similar proteinsi

Entry informationi

Entry nameiCLSB_ECO57
AccessioniPrimary (citable) accession number: P0AA85
Secondary accession number(s): P75771
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: April 25, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health