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Protein

Cardiolipin synthase B

Gene

clsB

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei113UniRule annotation1
Active sitei115UniRule annotation1
Active sitei120UniRule annotation1
Active sitei290UniRule annotation1
Active sitei292UniRule annotation1
Active sitei297UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase BUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:clsBUniRule annotation
Synonyms:ybhO
Ordered Locus Names:Z1008, ECs0867
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002012841 – 413Cardiolipin synthase BAdd BLAST413

Interactioni

Protein-protein interaction databases

STRINGi155864.Z1008.

Structurei

3D structure databases

ProteinModelPortaliP0AA85.
SMRiP0AA85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 135PLD phosphodiesterase 1UniRule annotationAdd BLAST28
Domaini285 – 312PLD phosphodiesterase 2UniRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsB sub-subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105DZQ. Bacteria.
COG1502. LUCA.
HOGENOMiHOG000264393.
KOiK06131.
OMAiTHRKILI.

Family and domain databases

HAMAPiMF_01917. Cardiolipin_synth_ClsB. 1 hit.
InterProiView protein in InterPro
IPR030872. Cardiolipin_synth_ClsB.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
PfamiView protein in Pfam
PF13091. PLDc_2. 2 hits.
SMARTiView protein in SMART
SM00155. PLDc. 2 hits.
PROSITEiView protein in PROSITE
PS50035. PLD. 2 hits.

Sequencei

Sequence statusi: Complete.

P0AA85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCSWREGNK IQLLENGEQY YPAVFKAIGE AQERIILETF IWFEDDVGKQ
60 70 80 90 100
LHAALLAAAQ RGVKAEVLLD GYGSPDLSDE FVNELTAAGV VFRYYDPRPR
110 120 130 140 150
LFGMRTNVFR RMHRKIVVID ARIAFIGGLN YSAEHMSSYG PEAKQDYAVR
160 170 180 190 200
LEGPIVEDIL QFELENLPGQ SAARRWWRRH HKAEENRQPG EAQVLLVWRD
210 220 230 240 250
NEEHRDDIER HYLKMLTQAR REVIIANAYF FPGYRFLHAL RKAARRGVRI
260 270 280 290 300
KLIIQGEPDM PIVRVGARLL YNYLVKGGVQ VFEYRRRPLH GKVALMDDHW
310 320 330 340 350
ATVGSSNLDP LSLSLNLEAN VIIHDRHFNQ TLRDNLNGII AADCQQVDET
360 370 380 390 400
MLPKRTWWNL TKSVLAFHFL RHFPALVGWL PAHTPRLAQV DPPAQPTMET
410
QDRVETENTG VKP
Length:413
Mass (Da):47,634
Last modified:September 13, 2005 - v1
Checksum:i74998B2A1AD24A11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG55160.1.
BA000007 Genomic DNA. Translation: BAB34290.1.
PIRiC90737.
D85587.
RefSeqiNP_308894.1. NC_002695.1.
WP_000650337.1. NZ_LPWC02000002.1.

Genome annotation databases

EnsemblBacteriaiAAG55160; AAG55160; Z1008.
BAB34290; BAB34290; BAB34290.
GeneIDi917609.
KEGGiece:Z1008.
ecs:ECs0867.
PATRICi18350764. VBIEscCol44059_0887.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG55160.1.
BA000007 Genomic DNA. Translation: BAB34290.1.
PIRiC90737.
D85587.
RefSeqiNP_308894.1. NC_002695.1.
WP_000650337.1. NZ_LPWC02000002.1.

3D structure databases

ProteinModelPortaliP0AA85.
SMRiP0AA85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z1008.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG55160; AAG55160; Z1008.
BAB34290; BAB34290; BAB34290.
GeneIDi917609.
KEGGiece:Z1008.
ecs:ECs0867.
PATRICi18350764. VBIEscCol44059_0887.

Phylogenomic databases

eggNOGiENOG4105DZQ. Bacteria.
COG1502. LUCA.
HOGENOMiHOG000264393.
KOiK06131.
OMAiTHRKILI.

Family and domain databases

HAMAPiMF_01917. Cardiolipin_synth_ClsB. 1 hit.
InterProiView protein in InterPro
IPR030872. Cardiolipin_synth_ClsB.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
PfamiView protein in Pfam
PF13091. PLDc_2. 2 hits.
SMARTiView protein in SMART
SM00155. PLDc. 2 hits.
PROSITEiView protein in PROSITE
PS50035. PLD. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCLSB_ECO57
AccessioniPrimary (citable) accession number: P0AA85
Secondary accession number(s): P75771
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: February 15, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.