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Protein

Cytosine permease

Gene

codB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for cytosine transport into the cell.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cytosine metabolism, Transport

Enzyme and pathway databases

BioCyciEcoCyc:CODB-MONOMER.
ECOL316407:JW0327-MONOMER.
MetaCyc:CODB-MONOMER.

Protein family/group databases

TCDBi2.A.39.1.1. the nucleobase:cation symporter-1 (ncs1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosine permease
Gene namesi
Name:codB
Ordered Locus Names:b0336, JW0327
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11327. codB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19Cytoplasmic1 PublicationAdd BLAST19
Transmembranei20 – 39Helical; Name=1CuratedAdd BLAST20
Topological domaini40 – 51Periplasmic1 PublicationAdd BLAST12
Transmembranei52 – 71Helical; Name=2CuratedAdd BLAST20
Topological domaini72 – 100Cytoplasmic1 PublicationAdd BLAST29
Transmembranei101 – 120Helical; Name=3CuratedAdd BLAST20
Topological domaini121 – 127Periplasmic1 Publication7
Transmembranei128 – 147Helical; Name=4CuratedAdd BLAST20
Topological domaini148 – 152Cytoplasmic1 Publication5
Transmembranei153 – 172Helical; Name=5CuratedAdd BLAST20
Topological domaini173 – 192Periplasmic1 PublicationAdd BLAST20
Transmembranei193 – 212Helical; Name=6CuratedAdd BLAST20
Topological domaini213 – 221Cytoplasmic1 Publication9
Transmembranei222 – 242Helical; Name=7CuratedAdd BLAST21
Topological domaini243 – 257Periplasmic1 PublicationAdd BLAST15
Transmembranei258 – 277Helical; Name=8CuratedAdd BLAST20
Topological domaini278 – 300Cytoplasmic1 PublicationAdd BLAST23
Transmembranei301 – 320Helical; Name=9CuratedAdd BLAST20
Topological domaini321Periplasmic1 Publication1
Transmembranei322 – 341Helical; Name=10CuratedAdd BLAST20
Topological domaini342 – 358Cytoplasmic1 PublicationAdd BLAST17
Transmembranei359 – 378Helical; Name=11CuratedAdd BLAST20
Topological domaini379 – 380Periplasmic1 Publication2
Transmembranei381 – 400Helical; Name=12CuratedAdd BLAST20
Topological domaini401 – 419Cytoplasmic1 PublicationAdd BLAST19

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001979321 – 419Cytosine permeaseAdd BLAST419

Proteomic databases

PaxDbiP0AA82.
PRIDEiP0AA82.

Interactioni

Protein-protein interaction databases

BioGridi4259812. 7 interactors.
STRINGi511145.b0336.

Structurei

3D structure databases

ProteinModelPortaliP0AA82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DQW. Bacteria.
COG1457. LUCA.
HOGENOMiHOG000117411.
InParanoidiP0AA82.
KOiK10974.
OMAiAWGTATI.
PhylomeDBiP0AA82.

Family and domain databases

InterProiIPR030191. CodB.
IPR001248. Pur-cyt_permease.
[Graphical view]
PANTHERiPTHR30569. PTHR30569. 1 hit.
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AA82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQDNNFSQG PVPQSARKGV LALTFVMLGL TFFSASMWTG GTLGTGLSYH
60 70 80 90 100
DFFLAVLIGN LLLGIYTSFL GYIGAKTGLT THLLARFSFG VKGSWLPSLL
110 120 130 140 150
LGGTQVGWFG VGVAMFAIPV GKATGLDINL LIAVSGLLMT VTVFFGISAL
160 170 180 190 200
TVLSVIAVPA IACLGGYSVW LAVNGMGGLD ALKAVVPAQP LDFNVALALV
210 220 230 240 250
VGSFISAGTL TADFVRFGRN AKLAVLVAMV AFFLGNSLMF IFGAAGAAAL
260 270 280 290 300
GMADISDVMI AQGLLLPAIV VLGLNIWTTN DNALYASGLG FANITGMSSK
310 320 330 340 350
TLSVINGIIG TVCALWLYNN FVGWLTFLSA AIPPVGGVII ADYLMNRRRY
360 370 380 390 400
EHFATTRMMS VNWVAILAVA LGIAAGHWLP GIVPVNAVLG GALSYLILNP
410
ILNRKTTAAM THVEANSVE
Length:419
Mass (Da):43,650
Last modified:September 13, 2005 - v1
Checksum:iCB1EDEBD84AA1D93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63656 Genomic DNA. Translation: CAA45195.1.
U73857 Genomic DNA. Translation: AAB18060.1.
U00096 Genomic DNA. Translation: AAC73439.1.
AP009048 Genomic DNA. Translation: BAE76118.1.
PIRiS22661.
RefSeqiNP_414870.1. NC_000913.3.
WP_000076233.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73439; AAC73439; b0336.
BAE76118; BAE76118; BAE76118.
GeneIDi944994.
KEGGiecj:JW0327.
eco:b0336.
PATRICi32115803. VBIEscCol129921_0343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63656 Genomic DNA. Translation: CAA45195.1.
U73857 Genomic DNA. Translation: AAB18060.1.
U00096 Genomic DNA. Translation: AAC73439.1.
AP009048 Genomic DNA. Translation: BAE76118.1.
PIRiS22661.
RefSeqiNP_414870.1. NC_000913.3.
WP_000076233.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AA82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259812. 7 interactors.
STRINGi511145.b0336.

Protein family/group databases

TCDBi2.A.39.1.1. the nucleobase:cation symporter-1 (ncs1) family.

Proteomic databases

PaxDbiP0AA82.
PRIDEiP0AA82.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73439; AAC73439; b0336.
BAE76118; BAE76118; BAE76118.
GeneIDi944994.
KEGGiecj:JW0327.
eco:b0336.
PATRICi32115803. VBIEscCol129921_0343.

Organism-specific databases

EchoBASEiEB1303.
EcoGeneiEG11327. codB.

Phylogenomic databases

eggNOGiENOG4105DQW. Bacteria.
COG1457. LUCA.
HOGENOMiHOG000117411.
InParanoidiP0AA82.
KOiK10974.
OMAiAWGTATI.
PhylomeDBiP0AA82.

Enzyme and pathway databases

BioCyciEcoCyc:CODB-MONOMER.
ECOL316407:JW0327-MONOMER.
MetaCyc:CODB-MONOMER.

Miscellaneous databases

PROiP0AA82.

Family and domain databases

InterProiIPR030191. CodB.
IPR001248. Pur-cyt_permease.
[Graphical view]
PANTHERiPTHR30569. PTHR30569. 1 hit.
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCODB_ECOLI
AccessioniPrimary (citable) accession number: P0AA82
Secondary accession number(s): P25525, Q2MC88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.