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Protein

Cytosine permease

Gene

codB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for cytosine transport into the cell.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCytosine metabolism, Transport

Enzyme and pathway databases

BioCyciEcoCyc:CODB-MONOMER
MetaCyc:CODB-MONOMER

Protein family/group databases

TCDBi2.A.39.1.1 the nucleobase:cation symporter-1 (ncs1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosine permease
Gene namesi
Name:codB
Ordered Locus Names:b0336, JW0327
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11327 codB

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19Cytoplasmic1 PublicationAdd BLAST19
Transmembranei20 – 39Helical; Name=1CuratedAdd BLAST20
Topological domaini40 – 51Periplasmic1 PublicationAdd BLAST12
Transmembranei52 – 71Helical; Name=2CuratedAdd BLAST20
Topological domaini72 – 100Cytoplasmic1 PublicationAdd BLAST29
Transmembranei101 – 120Helical; Name=3CuratedAdd BLAST20
Topological domaini121 – 127Periplasmic1 Publication7
Transmembranei128 – 147Helical; Name=4CuratedAdd BLAST20
Topological domaini148 – 152Cytoplasmic1 Publication5
Transmembranei153 – 172Helical; Name=5CuratedAdd BLAST20
Topological domaini173 – 192Periplasmic1 PublicationAdd BLAST20
Transmembranei193 – 212Helical; Name=6CuratedAdd BLAST20
Topological domaini213 – 221Cytoplasmic1 Publication9
Transmembranei222 – 242Helical; Name=7CuratedAdd BLAST21
Topological domaini243 – 257Periplasmic1 PublicationAdd BLAST15
Transmembranei258 – 277Helical; Name=8CuratedAdd BLAST20
Topological domaini278 – 300Cytoplasmic1 PublicationAdd BLAST23
Transmembranei301 – 320Helical; Name=9CuratedAdd BLAST20
Topological domaini321Periplasmic1 Publication1
Transmembranei322 – 341Helical; Name=10CuratedAdd BLAST20
Topological domaini342 – 358Cytoplasmic1 PublicationAdd BLAST17
Transmembranei359 – 378Helical; Name=11CuratedAdd BLAST20
Topological domaini379 – 380Periplasmic1 Publication2
Transmembranei381 – 400Helical; Name=12CuratedAdd BLAST20
Topological domaini401 – 419Cytoplasmic1 PublicationAdd BLAST19

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001979321 – 419Cytosine permeaseAdd BLAST419

Proteomic databases

PaxDbiP0AA82
PRIDEiP0AA82

Interactioni

Protein-protein interaction databases

BioGridi4259812, 7 interactors
STRINGi316407.85674478

Structurei

3D structure databases

ProteinModelPortaliP0AA82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DQW Bacteria
COG1457 LUCA
HOGENOMiHOG000117411
InParanoidiP0AA82
KOiK10974
OMAiNTIYNFA
PhylomeDBiP0AA82

Family and domain databases

Gene3Di1.10.4160.10, 1 hit
InterProiView protein in InterPro
IPR030191 CodB
IPR001248 Pur-cyt_permease
IPR038271 Pur-cyt_permease_sf
PANTHERiPTHR30569 PTHR30569, 1 hit
PfamiView protein in Pfam
PF02133 Transp_cyt_pur, 1 hit

Sequencei

Sequence statusi: Complete.

P0AA82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQDNNFSQG PVPQSARKGV LALTFVMLGL TFFSASMWTG GTLGTGLSYH
60 70 80 90 100
DFFLAVLIGN LLLGIYTSFL GYIGAKTGLT THLLARFSFG VKGSWLPSLL
110 120 130 140 150
LGGTQVGWFG VGVAMFAIPV GKATGLDINL LIAVSGLLMT VTVFFGISAL
160 170 180 190 200
TVLSVIAVPA IACLGGYSVW LAVNGMGGLD ALKAVVPAQP LDFNVALALV
210 220 230 240 250
VGSFISAGTL TADFVRFGRN AKLAVLVAMV AFFLGNSLMF IFGAAGAAAL
260 270 280 290 300
GMADISDVMI AQGLLLPAIV VLGLNIWTTN DNALYASGLG FANITGMSSK
310 320 330 340 350
TLSVINGIIG TVCALWLYNN FVGWLTFLSA AIPPVGGVII ADYLMNRRRY
360 370 380 390 400
EHFATTRMMS VNWVAILAVA LGIAAGHWLP GIVPVNAVLG GALSYLILNP
410
ILNRKTTAAM THVEANSVE
Length:419
Mass (Da):43,650
Last modified:September 13, 2005 - v1
Checksum:iCB1EDEBD84AA1D93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63656 Genomic DNA Translation: CAA45195.1
U73857 Genomic DNA Translation: AAB18060.1
U00096 Genomic DNA Translation: AAC73439.1
AP009048 Genomic DNA Translation: BAE76118.1
PIRiS22661
RefSeqiNP_414870.1, NC_000913.3
WP_000076233.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73439; AAC73439; b0336
BAE76118; BAE76118; BAE76118
GeneIDi944994
KEGGiecj:JW0327
eco:b0336
PATRICifig|1411691.4.peg.1941

Similar proteinsi

Entry informationi

Entry nameiCODB_ECOLI
AccessioniPrimary (citable) accession number: P0AA82
Secondary accession number(s): P25525, Q2MC88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: April 25, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health