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Protein

Cytosine permease

Gene

codB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for cytosine transport into the cell.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cytosine metabolism, Transport

Enzyme and pathway databases

BioCyciEcoCyc:CODB-MONOMER.
ECOL316407:JW0327-MONOMER.
MetaCyc:CODB-MONOMER.

Protein family/group databases

TCDBi2.A.39.1.1. the nucleobase:cation symporter-1 (ncs1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosine permease
Gene namesi
Name:codB
Ordered Locus Names:b0336, JW0327
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11327. codB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919Cytoplasmic1 PublicationAdd
BLAST
Transmembranei20 – 3920Helical; Name=1CuratedAdd
BLAST
Topological domaini40 – 5112Periplasmic1 PublicationAdd
BLAST
Transmembranei52 – 7120Helical; Name=2CuratedAdd
BLAST
Topological domaini72 – 10029Cytoplasmic1 PublicationAdd
BLAST
Transmembranei101 – 12020Helical; Name=3CuratedAdd
BLAST
Topological domaini121 – 1277Periplasmic1 Publication
Transmembranei128 – 14720Helical; Name=4CuratedAdd
BLAST
Topological domaini148 – 1525Cytoplasmic1 Publication
Transmembranei153 – 17220Helical; Name=5CuratedAdd
BLAST
Topological domaini173 – 19220Periplasmic1 PublicationAdd
BLAST
Transmembranei193 – 21220Helical; Name=6CuratedAdd
BLAST
Topological domaini213 – 2219Cytoplasmic1 Publication
Transmembranei222 – 24221Helical; Name=7CuratedAdd
BLAST
Topological domaini243 – 25715Periplasmic1 PublicationAdd
BLAST
Transmembranei258 – 27720Helical; Name=8CuratedAdd
BLAST
Topological domaini278 – 30023Cytoplasmic1 PublicationAdd
BLAST
Transmembranei301 – 32020Helical; Name=9CuratedAdd
BLAST
Topological domaini321 – 3211Periplasmic1 Publication
Transmembranei322 – 34120Helical; Name=10CuratedAdd
BLAST
Topological domaini342 – 35817Cytoplasmic1 PublicationAdd
BLAST
Transmembranei359 – 37820Helical; Name=11CuratedAdd
BLAST
Topological domaini379 – 3802Periplasmic1 Publication
Transmembranei381 – 40020Helical; Name=12CuratedAdd
BLAST
Topological domaini401 – 41919Cytoplasmic1 PublicationAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419Cytosine permeasePRO_0000197932Add
BLAST

Proteomic databases

PaxDbiP0AA82.
PRIDEiP0AA82.

Interactioni

Protein-protein interaction databases

BioGridi4259812. 7 interactions.
STRINGi511145.b0336.

Structurei

3D structure databases

ProteinModelPortaliP0AA82.
SMRiP0AA82. Positions 6-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DQW. Bacteria.
COG1457. LUCA.
HOGENOMiHOG000117411.
InParanoidiP0AA82.
KOiK10974.
OMAiMYELLIP.
OrthoDBiEOG6BW50N.
PhylomeDBiP0AA82.

Family and domain databases

InterProiIPR030191. CodB.
IPR001248. Pur-cyt_permease.
[Graphical view]
PANTHERiPTHR30569. PTHR30569. 1 hit.
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AA82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQDNNFSQG PVPQSARKGV LALTFVMLGL TFFSASMWTG GTLGTGLSYH
60 70 80 90 100
DFFLAVLIGN LLLGIYTSFL GYIGAKTGLT THLLARFSFG VKGSWLPSLL
110 120 130 140 150
LGGTQVGWFG VGVAMFAIPV GKATGLDINL LIAVSGLLMT VTVFFGISAL
160 170 180 190 200
TVLSVIAVPA IACLGGYSVW LAVNGMGGLD ALKAVVPAQP LDFNVALALV
210 220 230 240 250
VGSFISAGTL TADFVRFGRN AKLAVLVAMV AFFLGNSLMF IFGAAGAAAL
260 270 280 290 300
GMADISDVMI AQGLLLPAIV VLGLNIWTTN DNALYASGLG FANITGMSSK
310 320 330 340 350
TLSVINGIIG TVCALWLYNN FVGWLTFLSA AIPPVGGVII ADYLMNRRRY
360 370 380 390 400
EHFATTRMMS VNWVAILAVA LGIAAGHWLP GIVPVNAVLG GALSYLILNP
410
ILNRKTTAAM THVEANSVE
Length:419
Mass (Da):43,650
Last modified:September 13, 2005 - v1
Checksum:iCB1EDEBD84AA1D93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63656 Genomic DNA. Translation: CAA45195.1.
U73857 Genomic DNA. Translation: AAB18060.1.
U00096 Genomic DNA. Translation: AAC73439.1.
AP009048 Genomic DNA. Translation: BAE76118.1.
PIRiS22661.
RefSeqiNP_414870.1. NC_000913.3.
WP_000076233.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73439; AAC73439; b0336.
BAE76118; BAE76118; BAE76118.
GeneIDi944994.
KEGGiecj:JW0327.
eco:b0336.
PATRICi32115803. VBIEscCol129921_0343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63656 Genomic DNA. Translation: CAA45195.1.
U73857 Genomic DNA. Translation: AAB18060.1.
U00096 Genomic DNA. Translation: AAC73439.1.
AP009048 Genomic DNA. Translation: BAE76118.1.
PIRiS22661.
RefSeqiNP_414870.1. NC_000913.3.
WP_000076233.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AA82.
SMRiP0AA82. Positions 6-349.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259812. 7 interactions.
STRINGi511145.b0336.

Protein family/group databases

TCDBi2.A.39.1.1. the nucleobase:cation symporter-1 (ncs1) family.

Proteomic databases

PaxDbiP0AA82.
PRIDEiP0AA82.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73439; AAC73439; b0336.
BAE76118; BAE76118; BAE76118.
GeneIDi944994.
KEGGiecj:JW0327.
eco:b0336.
PATRICi32115803. VBIEscCol129921_0343.

Organism-specific databases

EchoBASEiEB1303.
EcoGeneiEG11327. codB.

Phylogenomic databases

eggNOGiENOG4105DQW. Bacteria.
COG1457. LUCA.
HOGENOMiHOG000117411.
InParanoidiP0AA82.
KOiK10974.
OMAiMYELLIP.
OrthoDBiEOG6BW50N.
PhylomeDBiP0AA82.

Enzyme and pathway databases

BioCyciEcoCyc:CODB-MONOMER.
ECOL316407:JW0327-MONOMER.
MetaCyc:CODB-MONOMER.

Miscellaneous databases

PROiP0AA82.

Family and domain databases

InterProiIPR030191. CodB.
IPR001248. Pur-cyt_permease.
[Graphical view]
PANTHERiPTHR30569. PTHR30569. 1 hit.
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the Escherichia coli codBA operon encoding cytosine permease and cytosine deaminase."
    Danielsen S., Kilstrup M., Barilla K., Jochimsen B., Neuhard J.
    Mol. Microbiol. 6:1335-1344(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CSH01.
  2. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiCODB_ECOLI
AccessioniPrimary (citable) accession number: P0AA82
Secondary accession number(s): P25525, Q2MC88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: July 6, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.