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Protein

Probable galactarate transporter

Gene

garP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Uptake of D-galactarate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:YHAU-MONOMER.
ECOL316407:JW3096-MONOMER.
MetaCyc:YHAU-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable galactarate transporter
Alternative name(s):
D-galactarate permease
Gene namesi
Name:garP
Synonyms:yhaU
Ordered Locus Names:b3127, JW3096
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12760. garP.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 56PeriplasmicSequence analysisAdd BLAST24
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Topological domaini78 – 89CytoplasmicSequence analysisAdd BLAST12
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 157CytoplasmicSequence analysisAdd BLAST26
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 252CytoplasmicSequence analysisAdd BLAST53
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21
Topological domaini274 – 288PeriplasmicSequence analysisAdd BLAST15
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310 – 319CytoplasmicSequence analysis10
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Topological domaini341 – 350PeriplasmicSequence analysis10
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Topological domaini372 – 385CytoplasmicSequence analysisAdd BLAST14
Transmembranei386 – 406HelicalSequence analysisAdd BLAST21
Topological domaini407 – 413PeriplasmicSequence analysis7
Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
Topological domaini435 – 444CytoplasmicSequence analysis10

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001213821 – 444Probable galactarate transporterAdd BLAST444

Proteomic databases

PaxDbiP0AA80.
PRIDEiP0AA80.

Interactioni

Protein-protein interaction databases

BioGridi4259486. 14 interactors.
STRINGi511145.b3127.

Structurei

3D structure databases

ProteinModelPortaliP0AA80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DJB. Bacteria.
ENOG410XPWC. LUCA.
HOGENOMiHOG000113642.
InParanoidiP0AA80.
KOiK12299.
OMAiQTPAMAV.
PhylomeDBiP0AA80.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004744. Dgal_transporter.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00893. 2A0114. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AA80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILDTVDEKK KGVHTRYLIL LIIFIVTAVN YADRATLSIA GTEVAKELQL
60 70 80 90 100
SAVSMGYIFS AFGWAYLLMQ IPGGWLLDKF GSKKVYTYSL FFWSLFTFLQ
110 120 130 140 150
GFVDMFPLAW AGISMFFMRF MLGFSEAPSF PANARIVAAW FPTKERGTAS
160 170 180 190 200
AIFNSAQYFS LALFSPLLGW LTFAWGWEHV FTVMGVIGFV LTALWIKLIH
210 220 230 240 250
NPTDHPRMSA EELKFISENG AVVDMDHKKP GSAAASGPKL HYIKQLLSNR
260 270 280 290 300
MMLGVFFGQY FINTITWFFL TWFPIYLVQE KGMSILKVGL VASIPALCGF
310 320 330 340 350
AGGVLGGVFS DYLIKRGLSL TLARKLPIVL GMLLASTIIL CNYTNNTTLV
360 370 380 390 400
VMLMALAFFG KGFGALGWPV ISDTAPKEIV GLCGGVFNVF GNVASIVTPL
410 420 430 440
VIGYLVSELH SFNAALVFVG CSALMAMVCY LFVVGDIKRM ELQK
Length:444
Mass (Da):49,009
Last modified:September 13, 2005 - v1
Checksum:i48FA27023B0C9D30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57930.1.
U00096 Genomic DNA. Translation: AAC76161.1.
AP009048 Genomic DNA. Translation: BAE77174.1.
PIRiC65102.
RefSeqiNP_417596.1. NC_000913.3.
WP_000599636.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76161; AAC76161; b3127.
BAE77174; BAE77174; BAE77174.
GeneIDi947642.
KEGGiecj:JW3096.
eco:b3127.
PATRICi32121668. VBIEscCol129921_3220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57930.1.
U00096 Genomic DNA. Translation: AAC76161.1.
AP009048 Genomic DNA. Translation: BAE77174.1.
PIRiC65102.
RefSeqiNP_417596.1. NC_000913.3.
WP_000599636.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AA80.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259486. 14 interactors.
STRINGi511145.b3127.

Proteomic databases

PaxDbiP0AA80.
PRIDEiP0AA80.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76161; AAC76161; b3127.
BAE77174; BAE77174; BAE77174.
GeneIDi947642.
KEGGiecj:JW3096.
eco:b3127.
PATRICi32121668. VBIEscCol129921_3220.

Organism-specific databases

EchoBASEiEB2613.
EcoGeneiEG12760. garP.

Phylogenomic databases

eggNOGiENOG4105DJB. Bacteria.
ENOG410XPWC. LUCA.
HOGENOMiHOG000113642.
InParanoidiP0AA80.
KOiK12299.
OMAiQTPAMAV.
PhylomeDBiP0AA80.

Enzyme and pathway databases

BioCyciEcoCyc:YHAU-MONOMER.
ECOL316407:JW3096-MONOMER.
MetaCyc:YHAU-MONOMER.

Miscellaneous databases

PROiP0AA80.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004744. Dgal_transporter.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00893. 2A0114. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGARP_ECOLI
AccessioniPrimary (citable) accession number: P0AA80
Secondary accession number(s): P42613, Q2M982
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.