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Protein

Hexuronate transporter

Gene

exuT

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Aldohexuronate transport system.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciECOL386585:GJFA-3935-MONOMER.
ECOO157:EXUT-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexuronate transporter
Gene namesi
Name:exuT
Ordered Locus Names:Z4446, ECs3975
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 4817CytoplasmicSequence analysisAdd
BLAST
Transmembranei49 – 6921HelicalSequence analysisAdd
BLAST
Topological domaini70 – 756PeriplasmicSequence analysis
Transmembranei76 – 9621HelicalSequence analysisAdd
BLAST
Topological domaini97 – 993CytoplasmicSequence analysis
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Topological domaini121 – 13818PeriplasmicSequence analysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence analysisAdd
BLAST
Topological domaini160 – 1645CytoplasmicSequence analysis
Transmembranei165 – 18521HelicalSequence analysisAdd
BLAST
Topological domaini186 – 23651PeriplasmicSequence analysisAdd
BLAST
Transmembranei237 – 25721HelicalSequence analysisAdd
BLAST
Topological domaini258 – 2647CytoplasmicSequence analysis
Transmembranei265 – 28521HelicalSequence analysisAdd
BLAST
Topological domaini286 – 30318PeriplasmicSequence analysisAdd
BLAST
Transmembranei304 – 32320HelicalSequence analysisAdd
BLAST
Topological domaini324 – 3274CytoplasmicSequence analysis
Transmembranei328 – 35023HelicalSequence analysisAdd
BLAST
Topological domaini351 – 36919PeriplasmicSequence analysisAdd
BLAST
Transmembranei370 – 39021HelicalSequence analysisAdd
BLAST
Topological domaini391 – 3911CytoplasmicSequence analysis
Transmembranei392 – 41221HelicalSequence analysisAdd
BLAST
Topological domaini413 – 43220PeriplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Chaini32 – 432401Hexuronate transporterPRO_0000121380Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi155864.Z4446.

Structurei

3D structure databases

ProteinModelPortaliP0AA79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DPW. Bacteria.
ENOG410ZVFJ. LUCA.
HOGENOMiHOG000113643.
KOiK08191.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004744. Dgal_transporter.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00893. 2A0114. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AA79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKIKGLRWY MIALVTLGTV LGYLTRNTVA AAAPTLMEEL NISTQQYSYI
60 70 80 90 100
IAAYSAAYTV MQPVAGYVLD VLGTKIGYAM FAVLWAVFCG ATALAGSWGG
110 120 130 140 150
LAVARGAVGA AEAAMIPAGL KASSEWFPAK ERSIAVGYFN VGSSIGAMIA
160 170 180 190 200
PPLVVWAIVM HSWQMAFIIS GALSFIWAMA WLIFYKHPRD QKHLTDEERD
210 220 230 240 250
YIINGQEAQH QVSTAKKMSV GQILRNRQFW GIALPRFLAE PAWGTFNAWI
260 270 280 290 300
PLFMFKVYGF NLKEIAMFAW MPMLFADLGC ILGGYLPPLF QRWFGVNLIV
310 320 330 340 350
SRKMVVTLGA VLMIGPGMIG LFTNPYVAIM LLCIGGFAHQ ALSGALITLS
360 370 380 390 400
SDVFGRNEVA TANGLTGMSA WLASTLFALV VGALADTIGF SPLFAVLAVF
410 420 430
DLLGALVIWT VLQNKPAIEV AQETHNDPAP QH
Length:432
Mass (Da):46,892
Last modified:June 11, 2014 - v2
Checksum:i9C3B2422F2B28ED8
GO

Sequence cautioni

The sequence AAG58226 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB37398 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG58226.1. Different initiation.
BA000007 Genomic DNA. Translation: BAB37398.1. Different initiation.
PIRiF85970.
G91125.
RefSeqiNP_312002.1. NC_002695.1.
WP_001226465.1. NZ_LPWC01000175.1.

Genome annotation databases

EnsemblBacteriaiAAG58226; AAG58226; Z4446.
BAB37398; BAB37398; BAB37398.
GeneIDi916191.
KEGGiece:Z4446.
ecs:ECs3975.
PATRICi18357455. VBIEscCol44059_3904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG58226.1. Different initiation.
BA000007 Genomic DNA. Translation: BAB37398.1. Different initiation.
PIRiF85970.
G91125.
RefSeqiNP_312002.1. NC_002695.1.
WP_001226465.1. NZ_LPWC01000175.1.

3D structure databases

ProteinModelPortaliP0AA79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z4446.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG58226; AAG58226; Z4446.
BAB37398; BAB37398; BAB37398.
GeneIDi916191.
KEGGiece:Z4446.
ecs:ECs3975.
PATRICi18357455. VBIEscCol44059_3904.

Phylogenomic databases

eggNOGiENOG4105DPW. Bacteria.
ENOG410ZVFJ. LUCA.
HOGENOMiHOG000113643.
KOiK08191.

Enzyme and pathway databases

BioCyciECOL386585:GJFA-3935-MONOMER.
ECOO157:EXUT-MONOMER.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004744. Dgal_transporter.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00893. 2A0114. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEXUT_ECO57
AccessioniPrimary (citable) accession number: P0AA79
Secondary accession number(s): P42609
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: June 11, 2014
Last modified: September 7, 2016
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.