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Protein

Hexuronate transporter

Gene

exuT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Aldohexuronate transport system.

GO - Molecular functioni

  • hexuronate transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • hexuronate transmembrane transport Source: EcoCyc

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:EXUT-MONOMER
MetaCyc:EXUT-MONOMER

Protein family/group databases

TCDBi2.A.1.14.2 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Hexuronate transporter
Gene namesi
Name:exuT
Ordered Locus Names:b3093, JW3064
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12738 exuT

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 48CytoplasmicSequence analysisAdd BLAST17
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 75PeriplasmicSequence analysis6
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 99CytoplasmicSequence analysis3
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Topological domaini121 – 138PeriplasmicSequence analysisAdd BLAST18
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 164CytoplasmicSequence analysis5
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 236PeriplasmicSequence analysisAdd BLAST51
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Topological domaini258 – 264CytoplasmicSequence analysis7
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
Topological domaini286 – 303PeriplasmicSequence analysisAdd BLAST18
Transmembranei304 – 323HelicalSequence analysisAdd BLAST20
Topological domaini324 – 327CytoplasmicSequence analysis4
Transmembranei328 – 350HelicalSequence analysisAdd BLAST23
Topological domaini351 – 369PeriplasmicSequence analysisAdd BLAST19
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Topological domaini391CytoplasmicSequence analysis1
Transmembranei392 – 412HelicalSequence analysisAdd BLAST21
Topological domaini413 – 432PeriplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000012137932 – 432Hexuronate transporterAdd BLAST401

Proteomic databases

PaxDbiP0AA78
PRIDEiP0AA78

Expressioni

Inductioni

Repressed by H-NS.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262409, 14 interactors
STRINGi316385.ECDH10B_3269

Structurei

3D structure databases

ProteinModelPortaliP0AA78
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DPW Bacteria
ENOG410ZVFJ LUCA
HOGENOMiHOG000113643
InParanoidiP0AA78
KOiK08191

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AA78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKIKGLRWY MIALVTLGTV LGYLTRNTVA AAAPTLMEEL NISTQQYSYI
60 70 80 90 100
IAAYSAAYTV MQPVAGYVLD VLGTKIGYAM FAVLWAVFCG ATALAGSWGG
110 120 130 140 150
LAVARGAVGA AEAAMIPAGL KASSEWFPAK ERSIAVGYFN VGSSIGAMIA
160 170 180 190 200
PPLVVWAIVM HSWQMAFIIS GALSFIWAMA WLIFYKHPRD QKHLTDEERD
210 220 230 240 250
YIINGQEAQH QVSTAKKMSV GQILRNRQFW GIALPRFLAE PAWGTFNAWI
260 270 280 290 300
PLFMFKVYGF NLKEIAMFAW MPMLFADLGC ILGGYLPPLF QRWFGVNLIV
310 320 330 340 350
SRKMVVTLGA VLMIGPGMIG LFTNPYVAIM LLCIGGFAHQ ALSGALITLS
360 370 380 390 400
SDVFGRNEVA TANGLTGMSA WLASTLFALV VGALADTIGF SPLFAVLAVF
410 420 430
DLLGALVIWT VLQNKPAIEV AQETHNDPAP QH
Length:432
Mass (Da):46,892
Last modified:June 11, 2014 - v2
Checksum:i9C3B2422F2B28ED8
GO

Sequence cautioni

The sequence AAA57897 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA02588 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAE77143 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13328 Genomic DNA Translation: BAA02588.1 Different initiation.
U18997 Genomic DNA Translation: AAA57897.1 Different initiation.
U00096 Genomic DNA Translation: AAC76128.2
AP009048 Genomic DNA Translation: BAE77143.1 Different initiation.
PIRiB65098
RefSeqiNP_417564.2, NC_000913.3
WP_001226465.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76128; AAC76128; b3093
BAE77143; BAE77143; BAE77143
GeneIDi947601
KEGGiecj:JW3064
eco:b3093
PATRICifig|511145.12.peg.3188

Similar proteinsi

Entry informationi

Entry nameiEXUT_ECOLI
AccessioniPrimary (citable) accession number: P0AA78
Secondary accession number(s): P42609, Q2M9B3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: June 11, 2014
Last modified: April 25, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health