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Protein

Hexuronate transporter

Gene

exuT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Aldohexuronate transport system.

GO - Molecular functioni

  • hexuronate transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • hexuronate transport Source: EcoCyc
  • hexuronide transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:EXUT-MONOMER.
ECOL316407:JW3064-MONOMER.
MetaCyc:EXUT-MONOMER.

Protein family/group databases

TCDBi2.A.1.14.2. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Hexuronate transporter
Gene namesi
Name:exuT
Ordered Locus Names:b3093, JW3064
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12738. exuT.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 4817CytoplasmicSequence analysisAdd
BLAST
Transmembranei49 – 6921HelicalSequence analysisAdd
BLAST
Topological domaini70 – 756PeriplasmicSequence analysis
Transmembranei76 – 9621HelicalSequence analysisAdd
BLAST
Topological domaini97 – 993CytoplasmicSequence analysis
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Topological domaini121 – 13818PeriplasmicSequence analysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence analysisAdd
BLAST
Topological domaini160 – 1645CytoplasmicSequence analysis
Transmembranei165 – 18521HelicalSequence analysisAdd
BLAST
Topological domaini186 – 23651PeriplasmicSequence analysisAdd
BLAST
Transmembranei237 – 25721HelicalSequence analysisAdd
BLAST
Topological domaini258 – 2647CytoplasmicSequence analysis
Transmembranei265 – 28521HelicalSequence analysisAdd
BLAST
Topological domaini286 – 30318PeriplasmicSequence analysisAdd
BLAST
Transmembranei304 – 32320HelicalSequence analysisAdd
BLAST
Topological domaini324 – 3274CytoplasmicSequence analysis
Transmembranei328 – 35023HelicalSequence analysisAdd
BLAST
Topological domaini351 – 36919PeriplasmicSequence analysisAdd
BLAST
Transmembranei370 – 39021HelicalSequence analysisAdd
BLAST
Topological domaini391 – 3911CytoplasmicSequence analysis
Transmembranei392 – 41221HelicalSequence analysisAdd
BLAST
Topological domaini413 – 43220PeriplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Chaini32 – 432401Hexuronate transporterPRO_0000121379Add
BLAST

Proteomic databases

PaxDbiP0AA78.
PRIDEiP0AA78.

Expressioni

Inductioni

Repressed by H-NS.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262409. 7 interactions.
STRINGi511145.b3093.

Structurei

3D structure databases

ProteinModelPortaliP0AA78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DPW. Bacteria.
ENOG410ZVFJ. LUCA.
HOGENOMiHOG000113643.
InParanoidiP0AA78.
KOiK08191.
OrthoDBiEOG6VTJZ1.

Family and domain databases

InterProiIPR004744. Dgal_transporter.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00893. 2A0114. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AA78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKIKGLRWY MIALVTLGTV LGYLTRNTVA AAAPTLMEEL NISTQQYSYI
60 70 80 90 100
IAAYSAAYTV MQPVAGYVLD VLGTKIGYAM FAVLWAVFCG ATALAGSWGG
110 120 130 140 150
LAVARGAVGA AEAAMIPAGL KASSEWFPAK ERSIAVGYFN VGSSIGAMIA
160 170 180 190 200
PPLVVWAIVM HSWQMAFIIS GALSFIWAMA WLIFYKHPRD QKHLTDEERD
210 220 230 240 250
YIINGQEAQH QVSTAKKMSV GQILRNRQFW GIALPRFLAE PAWGTFNAWI
260 270 280 290 300
PLFMFKVYGF NLKEIAMFAW MPMLFADLGC ILGGYLPPLF QRWFGVNLIV
310 320 330 340 350
SRKMVVTLGA VLMIGPGMIG LFTNPYVAIM LLCIGGFAHQ ALSGALITLS
360 370 380 390 400
SDVFGRNEVA TANGLTGMSA WLASTLFALV VGALADTIGF SPLFAVLAVF
410 420 430
DLLGALVIWT VLQNKPAIEV AQETHNDPAP QH
Length:432
Mass (Da):46,892
Last modified:June 11, 2014 - v2
Checksum:i9C3B2422F2B28ED8
GO

Sequence cautioni

The sequence AAA57897.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA02588.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAE77143.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13328 Genomic DNA. Translation: BAA02588.1. Different initiation.
U18997 Genomic DNA. Translation: AAA57897.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76128.2.
AP009048 Genomic DNA. Translation: BAE77143.1. Different initiation.
PIRiB65098.
RefSeqiNP_417564.2. NC_000913.3.
WP_001226465.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76128; AAC76128; b3093.
BAE77143; BAE77143; BAE77143.
GeneIDi947601.
KEGGiecj:JW3064.
eco:b3093.
PATRICi32121604. VBIEscCol129921_3188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13328 Genomic DNA. Translation: BAA02588.1. Different initiation.
U18997 Genomic DNA. Translation: AAA57897.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76128.2.
AP009048 Genomic DNA. Translation: BAE77143.1. Different initiation.
PIRiB65098.
RefSeqiNP_417564.2. NC_000913.3.
WP_001226465.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AA78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262409. 7 interactions.
STRINGi511145.b3093.

Protein family/group databases

TCDBi2.A.1.14.2. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP0AA78.
PRIDEiP0AA78.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76128; AAC76128; b3093.
BAE77143; BAE77143; BAE77143.
GeneIDi947601.
KEGGiecj:JW3064.
eco:b3093.
PATRICi32121604. VBIEscCol129921_3188.

Organism-specific databases

EchoBASEiEB2594.
EcoGeneiEG12738. exuT.

Phylogenomic databases

eggNOGiENOG4105DPW. Bacteria.
ENOG410ZVFJ. LUCA.
HOGENOMiHOG000113643.
InParanoidiP0AA78.
KOiK08191.
OrthoDBiEOG6VTJZ1.

Enzyme and pathway databases

BioCyciEcoCyc:EXUT-MONOMER.
ECOL316407:JW3064-MONOMER.
MetaCyc:EXUT-MONOMER.

Miscellaneous databases

PROiP0AA78.

Family and domain databases

InterProiIPR004744. Dgal_transporter.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00893. 2A0114. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Mizobuchi K.
    Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Involvement of the leucine response transcription factor LeuO in regulation of the genes for sulfa drug efflux."
    Shimada T., Yamamoto K., Ishihama A.
    J. Bacteriol. 191:4562-4571(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
    Strain: K12 / BW25113.

Entry informationi

Entry nameiEXUT_ECOLI
AccessioniPrimary (citable) accession number: P0AA78
Secondary accession number(s): P42609, Q2M9B3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: June 11, 2014
Last modified: February 17, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.