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Protein

Uncharacterized inner membrane transporter YhbE

Gene

yhbE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG11499-MONOMER.
ECOL316407:JW3151-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized inner membrane transporter YhbE
Gene namesi
Name:yhbE
Ordered Locus Names:b3184, JW3151
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11499. yhbE.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55CytoplasmicSequence analysis
Transmembranei6 – 2621HelicalSequence analysisAdd
BLAST
Topological domaini27 – 359PeriplasmicSequence analysis
Transmembranei36 – 5621HelicalSequence analysisAdd
BLAST
Topological domaini57 – 7014CytoplasmicSequence analysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence analysisAdd
BLAST
Topological domaini92 – 998PeriplasmicSequence analysis
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Topological domaini121 – 13010CytoplasmicSequence analysis
Transmembranei131 – 15121HelicalSequence analysisAdd
BLAST
Topological domaini152 – 1565PeriplasmicSequence analysis
Transmembranei157 – 17721HelicalSequence analysisAdd
BLAST
Topological domaini178 – 19013CytoplasmicSequence analysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence analysisAdd
BLAST
Topological domaini212 – 2165PeriplasmicSequence analysis
Transmembranei217 – 23721HelicalSequence analysisAdd
BLAST
Topological domaini238 – 24912CytoplasmicSequence analysisAdd
BLAST
Transmembranei250 – 27021HelicalSequence analysisAdd
BLAST
Topological domaini271 – 2788PeriplasmicSequence analysis
Transmembranei279 – 29921HelicalSequence analysisAdd
BLAST
Topological domaini300 – 32122CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible effect on bacterial persistence.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Uncharacterized inner membrane transporter YhbEPRO_0000108169Add
BLAST

Proteomic databases

PaxDbiP0AA73.
PRIDEiP0AA73.

Interactioni

Protein-protein interaction databases

BioGridi4259342. 9 interactions.
STRINGi511145.b3184.

Structurei

3D structure databases

ProteinModelPortaliP0AA73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 144128EamA 1Add
BLAST
Domaini169 – 292124EamA 2Add
BLAST

Sequence similaritiesi

Belongs to the EamA transporter family.Curated
Contains 2 EamA domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105QYV. Bacteria.
COG0697. LUCA.
HOGENOMiHOG000000467.
InParanoidiP0AA73.
OMAiCFIYCCL.
PhylomeDBiP0AA73.

Family and domain databases

InterProiIPR000620. EamA_dom.
[Graphical view]
PfamiPF00892. EamA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AA73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQQAGIGIL LALTTAICWG ALPIAMKQVL EVMEPPTIVF YRFLMASIGL
60 70 80 90 100
GAILAVKKRL PPLRVFRKPR WLILLAVATA GLFGNFILFS SSLQYLSPTA
110 120 130 140 150
SQVIGQLSPV GMMVASVFIL KEKMRSTQVV GALMLLSGLV MFFNTSLVEI
160 170 180 190 200
FTKLTDYTWG VIFGVGAATV WVSYGVAQKV LLRRLASPQI LFLLYTLCTI
210 220 230 240 250
ALFPLAKPGV IAQLSHWQLA CLIFCGLNTL VGYGALAEAM ARWQAAQVSA
260 270 280 290 300
IITLTPLFTL FFSDLLSLAW PDFFARPMLN LLGYLGAFVV VAGAMYSAIG
310 320
HRIWGGLRKH TTVVSQPRAG E
Length:321
Mass (Da):34,963
Last modified:September 13, 2005 - v1
Checksum:i9D1E6F9EE30C9518
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57985.1.
U00096 Genomic DNA. Translation: AAC76216.1.
AP009048 Genomic DNA. Translation: BAE77228.1.
D13267 Genomic DNA. Translation: BAA20990.1.
PIRiB65109.
RefSeqiNP_417651.1. NC_000913.3.
WP_000813037.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76216; AAC76216; b3184.
BAE77228; BAE77228; BAE77228.
GeneIDi947699.
KEGGiecj:JW3151.
eco:b3184.
PATRICi32121788. VBIEscCol129921_3278.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57985.1.
U00096 Genomic DNA. Translation: AAC76216.1.
AP009048 Genomic DNA. Translation: BAE77228.1.
D13267 Genomic DNA. Translation: BAA20990.1.
PIRiB65109.
RefSeqiNP_417651.1. NC_000913.3.
WP_000813037.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AA73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259342. 9 interactions.
STRINGi511145.b3184.

Proteomic databases

PaxDbiP0AA73.
PRIDEiP0AA73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76216; AAC76216; b3184.
BAE77228; BAE77228; BAE77228.
GeneIDi947699.
KEGGiecj:JW3151.
eco:b3184.
PATRICi32121788. VBIEscCol129921_3278.

Organism-specific databases

EchoBASEiEB1462.
EcoGeneiEG11499. yhbE.

Phylogenomic databases

eggNOGiENOG4105QYV. Bacteria.
COG0697. LUCA.
HOGENOMiHOG000000467.
InParanoidiP0AA73.
OMAiCFIYCCL.
PhylomeDBiP0AA73.

Enzyme and pathway databases

BioCyciEcoCyc:EG11499-MONOMER.
ECOL316407:JW3151-MONOMER.

Miscellaneous databases

PROiP0AA73.

Family and domain databases

InterProiIPR000620. EamA_dom.
[Graphical view]
PfamiPF00892. EamA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYHBE_ECOLI
AccessioniPrimary (citable) accession number: P0AA73
Secondary accession number(s): P28636, Q2M928
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: September 7, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.