Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Threonine/homoserine exporter RhtA

Gene

rhtA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the efflux of threonine and homoserine. Can also export other amino acids such as proline, serine, histidine and cysteine.1 Publication

GO - Molecular functioni

  • threonine efflux transmembrane transporter activity Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG12134-MONOMER.
ECOL316407:JW0798-MONOMER.
MetaCyc:EG12134-MONOMER.

Protein family/group databases

TCDBi2.A.7.3.6. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine/homoserine exporter RhtA
Gene namesi
Name:rhtA
Synonyms:ybiF
Ordered Locus Names:b0813, JW0798
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12134. rhtA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 38PeriplasmicSequence analysis8
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 71CytoplasmicSequence analysisAdd BLAST12
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Topological domaini93PeriplasmicSequence analysis1
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Topological domaini115 – 118CytoplasmicSequence analysis4
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 146PeriplasmicSequence analysis7
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 175CytoplasmicSequence analysis8
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 200PeriplasmicSequence analysis4
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 237CytoplasmicSequence analysisAdd BLAST16
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Topological domaini259 – 262PeriplasmicSequence analysis4
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 295CytoplasmicSequence analysisAdd BLAST12

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001081621 – 295Threonine/homoserine exporter RhtAAdd BLAST295

Proteomic databases

PaxDbiP0AA67.
PRIDEiP0AA67.

Interactioni

Protein-protein interaction databases

BioGridi4259985. 13 interactors.
STRINGi511145.b0813.

Structurei

3D structure databases

ProteinModelPortaliP0AA67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 135EamA 1Add BLAST106
Domaini159 – 278EamA 2Add BLAST120

Sequence similaritiesi

Contains 2 EamA domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107AQZ. Bacteria.
COG5006. LUCA.
HOGENOMiHOG000283695.
InParanoidiP0AA67.
KOiK11939.
OMAiMALGGMN.
PhylomeDBiP0AA67.

Family and domain databases

InterProiIPR000620. EamA_dom.
[Graphical view]
PfamiPF00892. EamA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AA67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGSLRKMPV WLPIVILLVA MASIQGGASL AKSLFPLVGA PGVTALRLAL
60 70 80 90 100
GTLILIAFFK PWRLRFAKEQ RLPLLFYGVS LGGMNYLFYL SIQTVPLGIA
110 120 130 140 150
VALEFTGPLA VALFSSRRPV DFVWVVLAVL GLWFLLPLGQ DVSHVDLTGC
160 170 180 190 200
ALALGAGACW AIYILSGQRA GAEHGPATVA IGSLIAALIF VPIGALQAGE
210 220 230 240 250
ALWHWSVIPL GLAVAILSTA LPYSLEMIAL TRLPTRTFGT LMSMEPALAA
260 270 280 290
VSGMIFLGET LTPIQLLALG AIIAASMGST LTVRKESKIK ELDIN
Length:295
Mass (Da):31,168
Last modified:September 13, 2005 - v1
Checksum:iEC830029E71BAD5F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti268A → R in AAA21854 (PubMed:8021175).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04242 Genomic DNA. Translation: AAA21854.1.
U00096 Genomic DNA. Translation: AAC73900.1.
AP009048 Genomic DNA. Translation: BAA35485.1.
PIRiE64818.
RefSeqiNP_415334.1. NC_000913.3.
WP_001295297.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73900; AAC73900; b0813.
BAA35485; BAA35485; BAA35485.
GeneIDi947045.
KEGGiecj:JW0798.
eco:b0813.
PATRICi32116829. VBIEscCol129921_0840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04242 Genomic DNA. Translation: AAA21854.1.
U00096 Genomic DNA. Translation: AAC73900.1.
AP009048 Genomic DNA. Translation: BAA35485.1.
PIRiE64818.
RefSeqiNP_415334.1. NC_000913.3.
WP_001295297.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AA67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259985. 13 interactors.
STRINGi511145.b0813.

Protein family/group databases

TCDBi2.A.7.3.6. the drug/metabolite transporter (dmt) superfamily.

Proteomic databases

PaxDbiP0AA67.
PRIDEiP0AA67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73900; AAC73900; b0813.
BAA35485; BAA35485; BAA35485.
GeneIDi947045.
KEGGiecj:JW0798.
eco:b0813.
PATRICi32116829. VBIEscCol129921_0840.

Organism-specific databases

EchoBASEiEB2055.
EcoGeneiEG12134. rhtA.

Phylogenomic databases

eggNOGiENOG4107AQZ. Bacteria.
COG5006. LUCA.
HOGENOMiHOG000283695.
InParanoidiP0AA67.
KOiK11939.
OMAiMALGGMN.
PhylomeDBiP0AA67.

Enzyme and pathway databases

BioCyciEcoCyc:EG12134-MONOMER.
ECOL316407:JW0798-MONOMER.
MetaCyc:EG12134-MONOMER.

Miscellaneous databases

PROiP0AA67.

Family and domain databases

InterProiIPR000620. EamA_dom.
[Graphical view]
PfamiPF00892. EamA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHTA_ECOLI
AccessioniPrimary (citable) accession number: P0AA67
Secondary accession number(s): P36545, P75784
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.