Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein QmcA

Gene

qmcA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Identified as a multi-copy suppressor of an FtsH/HtpX protease double disruption mutant. May play a role in the quality control of integral membrane proteins.

Enzyme and pathway databases

BioCyciEcoCyc:G6265-MONOMER.
ECOL316407:JW0478-MONOMER.

Protein family/group databases

TCDBi8.A.21.2.2. the stomatin/podocin/band 7/nephrosis.2/spfh (stomatin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein QmcA
Gene namesi
Name:qmcA
Synonyms:ybbK
Ordered Locus Names:b0489, JW0478
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13258. qmcA.

Subcellular locationi

  • Cell inner membrane 1 Publication; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2Periplasmic1 Publication2
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Topological domaini24 – 305Cytoplasmic1 PublicationAdd BLAST282

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000940561 – 305Protein QmcAAdd BLAST305

Proteomic databases

PaxDbiP0AA53.
PRIDEiP0AA53.

Interactioni

Subunit structurei

Forms oligomers. Probably interacts weakly with FtsH.1 Publication

Protein-protein interaction databases

BioGridi4259648. 14 interactors.
DIPiDIP-48137N.
IntActiP0AA53. 3 interactors.
STRINGi511145.b0489.

Structurei

3D structure databases

ProteinModelPortaliP0AA53.
SMRiP0AA53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the band 7/mec-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107QX8. Bacteria.
COG0330. LUCA.
HOGENOMiHOG000217039.
InParanoidiP0AA53.
OMAiIVRPYER.
PhylomeDBiP0AA53.

Family and domain databases

InterProiIPR001107. Band_7.
IPR018080. Band_7/stomatin-like_CS.
IPR032435. Band_7_C.
IPR001972. Stomatin_fam.
[Graphical view]
PANTHERiPTHR10264. PTHR10264. 1 hit.
PfamiPF01145. Band_7. 1 hit.
PF16200. Band_7_C. 1 hit.
[Graphical view]
PRINTSiPR00721. STOMATIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.
PROSITEiPS01270. BAND_7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AA53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIFIPILIF VALVIVGAGV KIVPQGYQWT VERFGRYTKT LQPGLSLVVP
60 70 80 90 100
FMDRIGRKIN MMEQVLDIPS QEVISKDNAN VTIDAVCFIQ VIDAPRAAYE
110 120 130 140 150
VSNLELAIIN LTMTNIRTVL GSMELDEMLS QRDSINSRLL RIVDEATNPW
160 170 180 190 200
GIKVTRIEIR DVRPPAELIS SMNAQMKAER TKRAYILEAE GIRQAEILKA
210 220 230 240 250
EGEKQSQILK AEGERQSAFL QAEARERSAE AEARATKMVS EAIASGDIQA
260 270 280 290 300
VNYFVAQKYT EALQQIGSSS NSKVVMMPLE ASSLMGSIAG IAELVKDSAN

KRTQP
Length:305
Mass (Da):33,743
Last modified:September 13, 2005 - v1
Checksum:i0A7800F65790ACC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA. Translation: AAB40243.1.
U00096 Genomic DNA. Translation: AAC73591.1.
AP009048 Genomic DNA. Translation: BAE76268.1.
PIRiH64779.
RefSeqiNP_415022.1. NC_000913.3.
WP_000904502.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73591; AAC73591; b0489.
BAE76268; BAE76268; BAE76268.
GeneIDi947257.
KEGGiecj:JW0478.
eco:b0489.
PATRICi32116137. VBIEscCol129921_0510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA. Translation: AAB40243.1.
U00096 Genomic DNA. Translation: AAC73591.1.
AP009048 Genomic DNA. Translation: BAE76268.1.
PIRiH64779.
RefSeqiNP_415022.1. NC_000913.3.
WP_000904502.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AA53.
SMRiP0AA53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259648. 14 interactors.
DIPiDIP-48137N.
IntActiP0AA53. 3 interactors.
STRINGi511145.b0489.

Protein family/group databases

TCDBi8.A.21.2.2. the stomatin/podocin/band 7/nephrosis.2/spfh (stomatin) family.

Proteomic databases

PaxDbiP0AA53.
PRIDEiP0AA53.

Protocols and materials databases

DNASUi947257.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73591; AAC73591; b0489.
BAE76268; BAE76268; BAE76268.
GeneIDi947257.
KEGGiecj:JW0478.
eco:b0489.
PATRICi32116137. VBIEscCol129921_0510.

Organism-specific databases

EchoBASEiEB3046.
EcoGeneiEG13258. qmcA.

Phylogenomic databases

eggNOGiENOG4107QX8. Bacteria.
COG0330. LUCA.
HOGENOMiHOG000217039.
InParanoidiP0AA53.
OMAiIVRPYER.
PhylomeDBiP0AA53.

Enzyme and pathway databases

BioCyciEcoCyc:G6265-MONOMER.
ECOL316407:JW0478-MONOMER.

Miscellaneous databases

PROiP0AA53.

Family and domain databases

InterProiIPR001107. Band_7.
IPR018080. Band_7/stomatin-like_CS.
IPR032435. Band_7_C.
IPR001972. Stomatin_fam.
[Graphical view]
PANTHERiPTHR10264. PTHR10264. 1 hit.
PfamiPF01145. Band_7. 1 hit.
PF16200. Band_7_C. 1 hit.
[Graphical view]
PRINTSiPR00721. STOMATIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.
PROSITEiPS01270. BAND_7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQMCA_ECOLI
AccessioniPrimary (citable) accession number: P0AA53
Secondary accession number(s): P77367, Q2MBT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: November 2, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.