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Protein

Protein QmcA

Gene

qmcA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Identified as a multi-copy suppressor of an FtsH/HtpX protease double disruption mutant. May play a role in the quality control of integral membrane proteins.

Enzyme and pathway databases

BioCyciEcoCyc:G6265-MONOMER

Protein family/group databases

TCDBi8.A.21.2.2 the stomatin/podocin/band 7/nephrosis,2/spfh (stomatin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Protein QmcA
Gene namesi
Name:qmcA
Synonyms:ybbK
Ordered Locus Names:b0489, JW0478
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13258 qmcA

Subcellular locationi

  • Cell inner membrane 1 Publication; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2Periplasmic1 Publication2
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Topological domaini24 – 305Cytoplasmic1 PublicationAdd BLAST282

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000940561 – 305Protein QmcAAdd BLAST305

Proteomic databases

PaxDbiP0AA53
PRIDEiP0AA53

Interactioni

Subunit structurei

Forms oligomers. Probably interacts weakly with FtsH.1 Publication

Protein-protein interaction databases

BioGridi4259648, 29 interactors
DIPiDIP-48137N
IntActiP0AA53, 3 interactors
STRINGi316385.ECDH10B_0446

Structurei

3D structure databases

ProteinModelPortaliP0AA53
SMRiP0AA53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the band 7/mec-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107QX8 Bacteria
COG0330 LUCA
HOGENOMiHOG000217039
InParanoidiP0AA53
OMAiRDQINGQ
PhylomeDBiP0AA53

Family and domain databases

InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR018080 Band_7/stomatin-like_CS
IPR032435 Band_7_C
IPR001972 Stomatin_fam
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PF16200 Band_7_C, 1 hit
PRINTSiPR00721 STOMATIN
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit
PROSITEiView protein in PROSITE
PS01270 BAND_7, 1 hit

Sequencei

Sequence statusi: Complete.

P0AA53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIFIPILIF VALVIVGAGV KIVPQGYQWT VERFGRYTKT LQPGLSLVVP
60 70 80 90 100
FMDRIGRKIN MMEQVLDIPS QEVISKDNAN VTIDAVCFIQ VIDAPRAAYE
110 120 130 140 150
VSNLELAIIN LTMTNIRTVL GSMELDEMLS QRDSINSRLL RIVDEATNPW
160 170 180 190 200
GIKVTRIEIR DVRPPAELIS SMNAQMKAER TKRAYILEAE GIRQAEILKA
210 220 230 240 250
EGEKQSQILK AEGERQSAFL QAEARERSAE AEARATKMVS EAIASGDIQA
260 270 280 290 300
VNYFVAQKYT EALQQIGSSS NSKVVMMPLE ASSLMGSIAG IAELVKDSAN

KRTQP
Length:305
Mass (Da):33,743
Last modified:September 13, 2005 - v1
Checksum:i0A7800F65790ACC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA Translation: AAB40243.1
U00096 Genomic DNA Translation: AAC73591.1
AP009048 Genomic DNA Translation: BAE76268.1
PIRiH64779
RefSeqiNP_415022.1, NC_000913.3
WP_000904502.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73591; AAC73591; b0489
BAE76268; BAE76268; BAE76268
GeneIDi947257
KEGGiecj:JW0478
eco:b0489
PATRICifig|1411691.4.peg.1787

Similar proteinsi

Entry informationi

Entry nameiQMCA_ECOLI
AccessioniPrimary (citable) accession number: P0AA53
Secondary accession number(s): P77367, Q2MBT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: March 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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