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Protein

tRNA pseudouridine synthase C

Gene

truC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for synthesis of pseudouridine from uracil-65 in transfer RNAs.1 Publication

Catalytic activityi

tRNA uridine(65) = tRNA pseudouridine(65).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei541

GO - Molecular functioni

  • pseudouridine synthase activity Source: EcoCyc
  • RNA binding Source: InterPro

GO - Biological processi

  • RNA modification Source: EcoliWiki
  • tRNA metabolic process Source: EcoliWiki
  • tRNA processing Source: EcoliWiki
  • tRNA pseudouridine synthesis Source: EcoCyc

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Enzyme and pathway databases

BioCyciEcoCyc:G7449-MONOMER
MetaCyc:G7449-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase C (EC:5.4.99.26)
Alternative name(s):
tRNA pseudouridine(65) synthase
tRNA pseudouridylate synthase C
tRNA-uridine isomerase C
Gene namesi
Name:truC
Synonyms:yqcB
Ordered Locus Names:b2791, JW2762
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13171 truC

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi54D → T: Loss of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001627111 – 260tRNA pseudouridine synthase CAdd BLAST260

Proteomic databases

PaxDbiP0AA41
PRIDEiP0AA41

Interactioni

Protein-protein interaction databases

BioGridi4262247, 15 interactors
IntActiP0AA41, 1 interactor
STRINGi316385.ECDH10B_2959

Structurei

3D structure databases

ProteinModelPortaliP0AA41
SMRiP0AA41
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudouridine synthase RluA family.Curated

Phylogenomic databases

eggNOGiENOG4105DR9 Bacteria
COG0564 LUCA
HOGENOMiHOG000275920
InParanoidiP0AA41
KOiK06175
OMAiQHVFPIH
PhylomeDBiP0AA41

Family and domain databases

InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR006224 PsdUridine_synth_RluC/D_CS
IPR006145 PsdUridine_synth_RsuA/RluD
PfamiView protein in Pfam
PF00849 PseudoU_synth_2, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
PROSITEiView protein in PROSITE
PS01129 PSI_RLU, 1 hit

Sequencei

Sequence statusi: Complete.

P0AA41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEILYQDEW LVAVNKPSGW LVHRSWLDRD EKVVVMQTVR DQIGQHVFTA
60 70 80 90 100
HRLDRPTSGV LLMGLSSEAG RLLAQQFEQH QIQKRYHAIV RGWLMEEAVL
110 120 130 140 150
DYPLVEELDK IADKFAREDK GPQPAVTHYR GLATVEMPVA TGRYPTTRYG
160 170 180 190 200
LVELEPKTGR KHQLRRHLAH LRHPIIGDSK HGDLRQNRSG AEHFGLQRLM
210 220 230 240 250
LHASQLSLTH PFTGEPLTIH AGLDDTWMQA LSQFGWRGLL PENERVEFSA
260
PSGQDGEISS
Length:260
Mass (Da):29,666
Last modified:September 13, 2005 - v1
Checksum:i0BEA421482CDB89A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29581 Genomic DNA Translation: AAB40441.1
U00096 Genomic DNA Translation: AAC75833.1
AP009048 Genomic DNA Translation: BAE76863.1
PIRiC65061
RefSeqiNP_417271.1, NC_000913.3
WP_000890001.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75833; AAC75833; b2791
BAE76863; BAE76863; BAE76863
GeneIDi947242
KEGGiecj:JW2762
eco:b2791
PATRICifig|1411691.4.peg.3942

Similar proteinsi

Entry informationi

Entry nameiTRUC_ECOLI
AccessioniPrimary (citable) accession number: P0AA41
Secondary accession number(s): Q2MA43, Q46918
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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