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Protein

tRNA pseudouridine synthase C

Gene

truC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for synthesis of pseudouridine from uracil-65 in transfer RNAs.1 Publication

Catalytic activityi

tRNA uridine(65) = tRNA pseudouridine(65).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei54 – 541

GO - Molecular functioni

  • pseudouridine synthase activity Source: EcoCyc
  • RNA binding Source: InterPro

GO - Biological processi

  • RNA modification Source: EcoliWiki
  • tRNA metabolic process Source: EcoliWiki
  • tRNA processing Source: EcoliWiki
  • tRNA pseudouridine synthesis Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

BioCyciEcoCyc:G7449-MONOMER.
ECOL316407:JW2762-MONOMER.
MetaCyc:G7449-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase C (EC:5.4.99.26)
Alternative name(s):
tRNA pseudouridine(65) synthase
tRNA pseudouridylate synthase C
tRNA-uridine isomerase C
Gene namesi
Name:truC
Synonyms:yqcB
Ordered Locus Names:b2791, JW2762
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13171. truC.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi54 – 541D → T: Loss of activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260tRNA pseudouridine synthase CPRO_0000162711Add
BLAST

Proteomic databases

PaxDbiP0AA41.

Interactioni

Protein-protein interaction databases

BioGridi4262247. 15 interactions.
IntActiP0AA41. 1 interaction.
STRINGi511145.b2791.

Structurei

3D structure databases

ProteinModelPortaliP0AA41.
SMRiP0AA41. Positions 2-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudouridine synthase RluA family.Curated

Phylogenomic databases

eggNOGiENOG4105DR9. Bacteria.
COG0564. LUCA.
HOGENOMiHOG000275920.
InParanoidiP0AA41.
KOiK06175.
OMAiQHVFPIH.
PhylomeDBiP0AA41.

Family and domain databases

InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
PROSITEiPS01129. PSI_RLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AA41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEILYQDEW LVAVNKPSGW LVHRSWLDRD EKVVVMQTVR DQIGQHVFTA
60 70 80 90 100
HRLDRPTSGV LLMGLSSEAG RLLAQQFEQH QIQKRYHAIV RGWLMEEAVL
110 120 130 140 150
DYPLVEELDK IADKFAREDK GPQPAVTHYR GLATVEMPVA TGRYPTTRYG
160 170 180 190 200
LVELEPKTGR KHQLRRHLAH LRHPIIGDSK HGDLRQNRSG AEHFGLQRLM
210 220 230 240 250
LHASQLSLTH PFTGEPLTIH AGLDDTWMQA LSQFGWRGLL PENERVEFSA
260
PSGQDGEISS
Length:260
Mass (Da):29,666
Last modified:September 13, 2005 - v1
Checksum:i0BEA421482CDB89A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29581 Genomic DNA. Translation: AAB40441.1.
U00096 Genomic DNA. Translation: AAC75833.1.
AP009048 Genomic DNA. Translation: BAE76863.1.
PIRiC65061.
RefSeqiNP_417271.1. NC_000913.3.
WP_000890001.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75833; AAC75833; b2791.
BAE76863; BAE76863; BAE76863.
GeneIDi947242.
KEGGiecj:JW2762.
eco:b2791.
PATRICi32120998. VBIEscCol129921_2891.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29581 Genomic DNA. Translation: AAB40441.1.
U00096 Genomic DNA. Translation: AAC75833.1.
AP009048 Genomic DNA. Translation: BAE76863.1.
PIRiC65061.
RefSeqiNP_417271.1. NC_000913.3.
WP_000890001.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AA41.
SMRiP0AA41. Positions 2-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262247. 15 interactions.
IntActiP0AA41. 1 interaction.
STRINGi511145.b2791.

Proteomic databases

PaxDbiP0AA41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75833; AAC75833; b2791.
BAE76863; BAE76863; BAE76863.
GeneIDi947242.
KEGGiecj:JW2762.
eco:b2791.
PATRICi32120998. VBIEscCol129921_2891.

Organism-specific databases

EchoBASEiEB2963.
EcoGeneiEG13171. truC.

Phylogenomic databases

eggNOGiENOG4105DR9. Bacteria.
COG0564. LUCA.
HOGENOMiHOG000275920.
InParanoidiP0AA41.
KOiK06175.
OMAiQHVFPIH.
PhylomeDBiP0AA41.

Enzyme and pathway databases

BioCyciEcoCyc:G7449-MONOMER.
ECOL316407:JW2762-MONOMER.
MetaCyc:G7449-MONOMER.

Miscellaneous databases

PROiP0AA41.

Family and domain databases

InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
PROSITEiPS01129. PSI_RLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRUC_ECOLI
AccessioniPrimary (citable) accession number: P0AA41
Secondary accession number(s): Q2MA43, Q46918
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.