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Protein

Thioredoxin 1

Gene

trxA

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei27Deprotonates C-terminal active site CysBy similarity1
Active sitei33NucleophileBy similarity1
Sitei34Contributes to redox potential valueBy similarity1
Sitei35Contributes to redox potential valueBy similarity1
Active sitei36NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin 1
Short name:
Trx-1
Gene namesi
Name:trxA
Ordered Locus Names:Z5291, ECs4714
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001200982 – 109Thioredoxin 1Add BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 36Redox-activePROSITE-ProRule annotation
Modified residuei70N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PRIDEiP0AA27

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi155864.Z5291

Structurei

Secondary structure

1109
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 8Combined sources4
Turni10 – 12Combined sources3
Helixi13 – 17Combined sources5
Beta strandi21 – 29Combined sources9
Helixi34 – 49Combined sources16
Turni50 – 53Combined sources4
Beta strandi54 – 60Combined sources7
Turni61 – 63Combined sources3
Helixi68 – 71Combined sources4
Beta strandi75 – 83Combined sources9
Beta strandi86 – 93Combined sources8
Helixi97 – 107Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DXBX-ray2.20A/B/C/D/E/F/G/H1-109[»]
5E4WX-ray2.80A/B3-109[»]
5IKNX-ray4.80K/L/M4-108[»]
ProteinModelPortaliP0AA27
SMRiP0AA27
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AA27

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 109ThioredoxinPROSITE-ProRule annotationAdd BLAST108

Sequence similaritiesi

Belongs to the thioredoxin family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105K63 Bacteria
COG0526 LUCA
HOGENOMiHOG000292977
KOiK03671
OMAiDANQEFA

Family and domain databases

InterProiView protein in InterPro
IPR005746 Thioredoxin
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PANTHERiPTHR10438 PTHR10438, 1 hit
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
PIRSFiPIRSF000077 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR01068 thioredoxin, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AA27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKIIHLTD DSFDTDVLKA DGAILVDFWA EWCGPCKMIA PILDEIADEY
60 70 80 90 100
QGKLTVAKLN IDQNPGTAPK YGIRGIPTLL LFKNGEVAAT KVGALSKGQL

KEFLDANLA
Length:109
Mass (Da):11,807
Last modified:January 23, 2007 - v2
Checksum:iEF5933EA29668EE9
GO

Sequence cautioni

The sequence AAG58975 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB38137 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG58975.1 Different initiation.
BA000007 Genomic DNA Translation: BAB38137.1 Different initiation.
RefSeqiNP_312741.1, NC_002695.1
WP_001280776.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG58975; AAG58975; Z5291
BAB38137; BAB38137; BAB38137
GeneIDi23335415
915255
KEGGiece:Z5291
ecs:ECs4714
PATRICifig|386585.9.peg.4918

Similar proteinsi

Entry informationi

Entry nameiTHIO_ECO57
AccessioniPrimary (citable) accession number: P0AA27
Secondary accession number(s): P00274
, P76750, Q47674, Q8XAT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health