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Protein

Transcriptional regulatory protein OmpR

Gene

ompR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The N-terminus of this protein is required for the transcriptional expression of both major outer membrane protein genes ompF and ompC; its C-terminal moiety mediates the multimerization of the OmpR protein. As a multimer, it turns on the expression of the ompC gene; as a monomer, it turns on the expression of the ompF gene.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi135 – 234OmpR/PhoB-typePROSITE-ProRule annotationAdd BLAST100

GO - Molecular functioni

GO - Biological processi

  • phosphorelay signal transduction system Source: EcoliWiki
  • positive regulation of transcription, DNA-templated Source: EcoliWiki
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation, Two-component regulatory system

Enzyme and pathway databases

BioCyciEcoCyc:OMPR-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein OmpR
Gene namesi
Name:ompR
Synonyms:kmt, ompB
Ordered Locus Names:b3405, JW3368
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10672 ompR

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • protein-DNA complex Source: CollecTF

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000811761 – 239Transcriptional regulatory protein OmpRAdd BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei554-aspartylphosphatePROSITE-ProRule annotation1 Publication1

Post-translational modificationi

Phosphorylated by EnvZ. Asp-55 is the primary phosphate acceptor site, but Asp-11 may also serve as a phosphorylation site, particularly in the absence of Asp-55.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP0AA16
PaxDbiP0AA16
PRIDEiP0AA16

Expressioni

Gene expression databases

CollecTFiEXPREG_00000810

Interactioni

Subunit structurei

Monomer and multimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
envZP0AEJ42EBI-369514,EBI-1121750

Protein-protein interaction databases

BioGridi4261267, 31 interactors
DIPiDIP-31859N
IntActiP0AA16, 10 interactors
STRINGi316385.ECDH10B_3580

Structurei

Secondary structure

1239
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi138 – 140Combined sources3
Beta strandi143 – 146Combined sources4
Turni147 – 150Combined sources4
Beta strandi151 – 154Combined sources4
Beta strandi157 – 159Combined sources3
Helixi163 – 174Combined sources12
Helixi182 – 189Combined sources8
Beta strandi192 – 194Combined sources3
Helixi201 – 212Combined sources12
Beta strandi220 – 225Combined sources6
Turni226 – 228Combined sources3
Beta strandi229 – 232Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ODDX-ray2.20A122-239[»]
1OPCX-ray1.95A130-239[»]
2JPBNMR-A136-239[»]
ProteinModelPortaliP0AA16
SMRiP0AA16
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AA16

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 120Response regulatoryPROSITE-ProRule annotationAdd BLAST115

Phylogenomic databases

HOGENOMiHOG000034819
InParanoidiP0AA16
KOiK07659
OMAiRKPWQVF
PhylomeDBiP0AA16

Family and domain databases

CDDicd00156 REC, 1 hit
cd00383 trans_reg_C, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011006 CheY-like_superfamily
IPR001867 OmpR/PhoB-type_DNA-bd
IPR016032 Sig_transdc_resp-reg_C-effctor
IPR001789 Sig_transdc_resp-reg_receiver
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00072 Response_reg, 1 hit
PF00486 Trans_reg_C, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SM00862 Trans_reg_C, 1 hit
SUPFAMiSSF46894 SSF46894, 1 hit
SSF52172 SSF52172, 1 hit
PROSITEiView protein in PROSITE
PS51755 OMPR_PHOB, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

P0AA16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQENYKILVV DDDMRLRALL ERYLTEQGFQ VRSVANAEQM DRLLTRESFH
60 70 80 90 100
LMVLDLMLPG EDGLSICRRL RSQSNPMPII MVTAKGEEVD RIVGLEIGAD
110 120 130 140 150
DYIPKPFNPR ELLARIRAVL RRQANELPGA PSQEEAVIAF GKFKLNLGTR
160 170 180 190 200
EMFREDEPMP LTSGEFAVLK ALVSHPREPL SRDKLMNLAR GREYSAMERS
210 220 230
IDVQISRLRR MVEEDPAHPR YIQTVWGLGY VFVPDGSKA
Length:239
Mass (Da):27,354
Last modified:September 13, 2005 - v1
Checksum:i823CA7720E9A1D2A
GO

Sequence cautioni

The sequence described in PubMed:6292199 differs from that shown. Reason: Frameshift at position 210.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7I → N (PubMed:3010044).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01656 Unassigned RNA Translation: AAA16241.1
U18997 Genomic DNA Translation: AAA58202.1
U00096 Genomic DNA Translation: AAC76430.1
AP009048 Genomic DNA Translation: BAE77886.1
PIRiH65135 RGECOR
RefSeqiNP_417864.1, NC_000913.3
WP_001157751.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76430; AAC76430; b3405
BAE77886; BAE77886; BAE77886
GeneIDi8912757
947913
KEGGiecj:JW3368
eco:b3405
PATRICifig|1411691.4.peg.3324

Similar proteinsi

Entry informationi

Entry nameiOMPR_ECOLI
AccessioniPrimary (citable) accession number: P0AA16
Secondary accession number(s): O31133
, P03025, P08981, P41405, Q2M770
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 13, 2005
Last modified: April 25, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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