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P0AA06

- PTHP_ECO57

UniProt

P0AA06 - PTHP_ECO57

Protein

Phosphocarrier protein HPr

Gene

ptsH

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III) By similarity.By similarity

    Catalytic activityi

    Protein HPr N(pi)-phospho-L-histidine + protein EIIA = protein HPr + protein EIIA N(tau)-phospho-L-histidine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei15 – 151Pros-phosphohistidine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. phosphoenolpyruvate-dependent sugar phosphotransferase system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Phosphotransferase system, Sugar transport, Transport

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-3248-MONOMER.
    ECOO157:PTSH-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphocarrier protein HPr (EC:2.7.11.-)
    Alternative name(s):
    Histidine-containing protein
    Gene namesi
    Name:ptsH
    Ordered Locus Names:Z3681, ECs3287
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8585Phosphocarrier protein HPrPRO_0000107852Add
    BLAST

    Proteomic databases

    PRIDEiP0AA06.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-246002.
    STRINGi155864.Z3681.

    Structurei

    3D structure databases

    ProteinModelPortaliP0AA06.
    SMRiP0AA06. Positions 1-85.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8585HPrPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the HPr family.Curated
    Contains 1 HPr domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1925.
    HOGENOMiHOG000278399.
    KOiK02784.
    OMAiMAERFNA.
    OrthoDBiEOG6XDGX2.

    Family and domain databases

    Gene3Di3.30.1340.10. 1 hit.
    InterProiIPR000032. HPr_prot-like.
    IPR001020. PTS_HPr_His_P_site.
    IPR002114. PTS_HPr_Ser_P_site.
    [Graphical view]
    PfamiPF00381. PTS-HPr. 1 hit.
    [Graphical view]
    PRINTSiPR00107. PHOSPHOCPHPR.
    SUPFAMiSSF55594. SSF55594. 1 hit.
    TIGRFAMsiTIGR01003. PTS_HPr_family. 1 hit.
    PROSITEiPS51350. PTS_HPR_DOM. 1 hit.
    PS00369. PTS_HPR_HIS. 1 hit.
    PS00589. PTS_HPR_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0AA06-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFQQEVTITA PNGLHTRPAA QFVKEAKGFT SEITVTSNGK SASAKSLFKL   50
    QTLGLTQGTV VTISAEGEDE QKAVEHLVKL MAELE 85
    Length:85
    Mass (Da):9,119
    Last modified:April 1, 1988 - v1
    Checksum:iE5C8879C0A95AD41
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG57534.1.
    BA000007 Genomic DNA. Translation: BAB36710.1.
    PIRiB85884.
    G91039.
    RefSeqiNP_288977.1. NC_002655.2.
    NP_311314.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG57534; AAG57534; Z3681.
    BAB36710; BAB36710; BAB36710.
    GeneIDi915540.
    957637.
    KEGGiece:Z3681.
    ecs:ECs3287.
    PATRICi18355990. VBIEscCol44059_3190.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG57534.1 .
    BA000007 Genomic DNA. Translation: BAB36710.1 .
    PIRi B85884.
    G91039.
    RefSeqi NP_288977.1. NC_002655.2.
    NP_311314.1. NC_002695.1.

    3D structure databases

    ProteinModelPortali P0AA06.
    SMRi P0AA06. Positions 1-85.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-246002.
    STRINGi 155864.Z3681.

    Proteomic databases

    PRIDEi P0AA06.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG57534 ; AAG57534 ; Z3681 .
    BAB36710 ; BAB36710 ; BAB36710 .
    GeneIDi 915540.
    957637.
    KEGGi ece:Z3681.
    ecs:ECs3287.
    PATRICi 18355990. VBIEscCol44059_3190.

    Phylogenomic databases

    eggNOGi COG1925.
    HOGENOMi HOG000278399.
    KOi K02784.
    OMAi MAERFNA.
    OrthoDBi EOG6XDGX2.

    Enzyme and pathway databases

    BioCyci ECOL386585:GJFA-3248-MONOMER.
    ECOO157:PTSH-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1340.10. 1 hit.
    InterProi IPR000032. HPr_prot-like.
    IPR001020. PTS_HPr_His_P_site.
    IPR002114. PTS_HPr_Ser_P_site.
    [Graphical view ]
    Pfami PF00381. PTS-HPr. 1 hit.
    [Graphical view ]
    PRINTSi PR00107. PHOSPHOCPHPR.
    SUPFAMi SSF55594. SSF55594. 1 hit.
    TIGRFAMsi TIGR01003. PTS_HPr_family. 1 hit.
    PROSITEi PS51350. PTS_HPR_DOM. 1 hit.
    PS00369. PTS_HPR_HIS. 1 hit.
    PS00589. PTS_HPR_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiPTHP_ECO57
    AccessioniPrimary (citable) accession number: P0AA06
    Secondary accession number(s): P05525, P07006
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: April 1, 1988
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3