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P0AA06 (PTHP_ECO57) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphocarrier protein HPr

EC=2.7.11.-
Alternative name(s):
Histidine-containing protein
Gene names
Name:ptsH
Ordered Locus Names:Z3681, ECs3287
OrganismEscherichia coli O157:H7 [Complete proteome] [HAMAP]
Taxonomic identifier83334 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length85 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III) By similarity.

Catalytic activity

Protein HPr N(pi)-phospho-L-histidine + protein EIIA = protein HPr + protein EIIA N(tau)-phospho-L-histidine.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the HPr family.

Contains 1 HPr domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8585Phosphocarrier protein HPr
PRO_0000107852

Regions

Domain1 – 8585HPr

Sites

Active site151Pros-phosphohistidine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P0AA06 [UniParc].

Last modified April 1, 1988. Version 1.
Checksum: E5C8879C0A95AD41

FASTA859,119
        10         20         30         40         50         60 
MFQQEVTITA PNGLHTRPAA QFVKEAKGFT SEITVTSNGK SASAKSLFKL QTLGLTQGTV 

        70         80 
VTISAEGEDE QKAVEHLVKL MAELE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005174 Genomic DNA. Translation: AAG57534.1.
BA000007 Genomic DNA. Translation: BAB36710.1.
PIRB85884.
G91039.
RefSeqNP_288977.1. NC_002655.2.
NP_311314.1. NC_002695.1.

3D structure databases

ProteinModelPortalP0AA06.
SMRP0AA06. Positions 1-85.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-246002.
STRING155864.Z3681.

Proteomic databases

PRIDEP0AA06.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG57534; AAG57534; Z3681.
BAB36710; BAB36710; BAB36710.
GeneID915540.
957637.
KEGGece:Z3681.
ecs:ECs3287.
PATRIC18355990. VBIEscCol44059_3190.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1925.
HOGENOMHOG000278399.
KOK02784.
OMASYQGKDV.
OrthoDBEOG6XDGX2.
ProtClustDBPRK10850.

Enzyme and pathway databases

BioCycECOL386585:GJFA-3248-MONOMER.
ECOO157:PTSH-MONOMER.

Family and domain databases

Gene3D3.30.1340.10. 1 hit.
InterProIPR001020. PTS_HPr_His_P_site.
IPR005698. PTS_HPr_prot.
IPR000032. PTS_HPr_prot-like.
IPR002114. PTS_HPr_Ser_P_site.
[Graphical view]
PfamPF00381. PTS-HPr. 1 hit.
[Graphical view]
PRINTSPR00107. PHOSPHOCPHPR.
SUPFAMSSF55594. SSF55594. 1 hit.
TIGRFAMsTIGR01003. PTS_HPr_family. 1 hit.
PROSITEPS51350. PTS_HPR_DOM. 1 hit.
PS00369. PTS_HPR_HIS. 1 hit.
PS00589. PTS_HPR_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePTHP_ECO57
AccessionPrimary (citable) accession number: P0AA06
Secondary accession number(s): P05525, P07006
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: April 16, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families