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P0AA06

- PTHP_ECO57

UniProt

P0AA06 - PTHP_ECO57

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Protein

Phosphocarrier protein HPr

Gene

ptsH

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III) (By similarity).By similarity

Catalytic activityi

Protein HPr N(pi)-phospho-L-histidine + protein EIIA = protein HPr + protein EIIA N(tau)-phospho-L-histidine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei15 – 151Pros-phosphohistidine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. phosphoenolpyruvate-dependent sugar phosphotransferase system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Phosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciECOL386585:GJFA-3248-MONOMER.
ECOO157:PTSH-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphocarrier protein HPr (EC:2.7.11.-)
Alternative name(s):
Histidine-containing protein
Gene namesi
Name:ptsH
Ordered Locus Names:Z3681, ECs3287
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8585Phosphocarrier protein HPrPRO_0000107852Add
BLAST

Proteomic databases

PRIDEiP0AA06.

Interactioni

Protein-protein interaction databases

MINTiMINT-246002.
STRINGi155864.Z3681.

Structurei

3D structure databases

ProteinModelPortaliP0AA06.
SMRiP0AA06. Positions 1-85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8585HPrPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the HPr family.Curated
Contains 1 HPr domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1925.
HOGENOMiHOG000278399.
KOiK02784.
OMAiMAERFNA.
OrthoDBiEOG6XDGX2.

Family and domain databases

Gene3Di3.30.1340.10. 1 hit.
InterProiIPR000032. HPr_prot-like.
IPR001020. PTS_HPr_His_P_site.
IPR002114. PTS_HPr_Ser_P_site.
[Graphical view]
PfamiPF00381. PTS-HPr. 1 hit.
[Graphical view]
PRINTSiPR00107. PHOSPHOCPHPR.
SUPFAMiSSF55594. SSF55594. 1 hit.
TIGRFAMsiTIGR01003. PTS_HPr_family. 1 hit.
PROSITEiPS51350. PTS_HPR_DOM. 1 hit.
PS00369. PTS_HPR_HIS. 1 hit.
PS00589. PTS_HPR_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AA06-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFQQEVTITA PNGLHTRPAA QFVKEAKGFT SEITVTSNGK SASAKSLFKL
60 70 80
QTLGLTQGTV VTISAEGEDE QKAVEHLVKL MAELE
Length:85
Mass (Da):9,119
Last modified:April 1, 1988 - v1
Checksum:iE5C8879C0A95AD41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57534.1.
BA000007 Genomic DNA. Translation: BAB36710.1.
PIRiB85884.
G91039.
RefSeqiNP_288977.1. NC_002655.2.
NP_311314.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG57534; AAG57534; Z3681.
BAB36710; BAB36710; BAB36710.
GeneIDi915540.
957637.
KEGGiece:Z3681.
ecs:ECs3287.
PATRICi18355990. VBIEscCol44059_3190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57534.1 .
BA000007 Genomic DNA. Translation: BAB36710.1 .
PIRi B85884.
G91039.
RefSeqi NP_288977.1. NC_002655.2.
NP_311314.1. NC_002695.1.

3D structure databases

ProteinModelPortali P0AA06.
SMRi P0AA06. Positions 1-85.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-246002.
STRINGi 155864.Z3681.

Proteomic databases

PRIDEi P0AA06.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG57534 ; AAG57534 ; Z3681 .
BAB36710 ; BAB36710 ; BAB36710 .
GeneIDi 915540.
957637.
KEGGi ece:Z3681.
ecs:ECs3287.
PATRICi 18355990. VBIEscCol44059_3190.

Phylogenomic databases

eggNOGi COG1925.
HOGENOMi HOG000278399.
KOi K02784.
OMAi MAERFNA.
OrthoDBi EOG6XDGX2.

Enzyme and pathway databases

BioCyci ECOL386585:GJFA-3248-MONOMER.
ECOO157:PTSH-MONOMER.

Family and domain databases

Gene3Di 3.30.1340.10. 1 hit.
InterProi IPR000032. HPr_prot-like.
IPR001020. PTS_HPr_His_P_site.
IPR002114. PTS_HPr_Ser_P_site.
[Graphical view ]
Pfami PF00381. PTS-HPr. 1 hit.
[Graphical view ]
PRINTSi PR00107. PHOSPHOCPHPR.
SUPFAMi SSF55594. SSF55594. 1 hit.
TIGRFAMsi TIGR01003. PTS_HPr_family. 1 hit.
PROSITEi PS51350. PTS_HPR_DOM. 1 hit.
PS00369. PTS_HPR_HIS. 1 hit.
PS00589. PTS_HPR_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiPTHP_ECO57
AccessioniPrimary (citable) accession number: P0AA06
Secondary accession number(s): P05525, P07006
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3