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Protein

Nitrogen regulatory protein P-II 1

Gene

glnB

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

P-II indirectly controls the transcription of the glutamine synthetase gene (GlnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandNucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nitrogen regulatory protein P-II 1
Gene namesi
Name:glnB
Ordered Locus Names:Z3829, ECs3419
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001397731 – 112Nitrogen regulatory protein P-II 1Add BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51O-UMP-tyrosinePROSITE-ProRule annotation1

Post-translational modificationi

Uridylylated/deuridylylated by GlnD.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP0A9Z3

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi155864.Z3829

Structurei

3D structure databases

ProteinModelPortaliP0A9Z3
SMRiP0A9Z3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P(II) protein family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108YZA Bacteria
COG0347 LUCA
HOGENOMiHOG000017847
KOiK04751
OMAiHQIEVNF

Family and domain databases

Gene3Di3.30.70.120, 1 hit
InterProiView protein in InterPro
IPR002187 N-reg_PII
IPR011322 N-reg_PII-like_a/b
IPR015867 N-reg_PII/ATP_PRibTrfase_C
IPR017918 N-reg_PII_CS
IPR002332 N-reg_PII_urydylation_site
PANTHERiPTHR30115 PTHR30115, 1 hit
PfamiView protein in Pfam
PF00543 P-II, 1 hit
PIRSFiPIRSF039144 GlnB, 1 hit
PRINTSiPR00340 PIIGLNB
SMARTiView protein in SMART
SM00938 P-II, 1 hit
SUPFAMiSSF54913 SSF54913, 1 hit
PROSITEiView protein in PROSITE
PS00638 PII_GLNB_CTER, 1 hit
PS51343 PII_GLNB_DOM, 1 hit
PS00496 PII_GLNB_UMP, 1 hit

Sequencei

Sequence statusi: Complete.

P0A9Z3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKIDAIIKP FKLDDVREAL AEVGITGMTV TEVKGFGRQK GHTELYRGAE
60 70 80 90 100
YMVDFLPKVK IEIVVPDDIV DTCVDTIIRT AQTGKIGDGK IFVFDVARVI
110
RIRTGEEDDA AI
Length:112
Mass (Da):12,425
Last modified:September 13, 2005 - v1
Checksum:iD1A4158A2F225042
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG57667.1
BA000007 Genomic DNA Translation: BAB36842.1
PIRiC91056
RefSeqiNP_311446.1, NC_002695.1
WP_000717694.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG57667; AAG57667; Z3829
BAB36842; BAB36842; BAB36842
GeneIDi23339395
914897
KEGGiece:Z3829
ecs:ECs3419
PATRICifig|386585.9.peg.3573

Similar proteinsi

Entry informationi

Entry nameiGLNB_ECO57
AccessioniPrimary (citable) accession number: P0A9Z3
Secondary accession number(s): P05826
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: April 25, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health