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Protein

Cold shock-like protein CspC

Gene

cspC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • chaperone binding Source: CACAO
  • RNA binding Source: EcoliWiki
  • single-stranded DNA binding Source: EcoliWiki
  • transcription antitermination factor activity, RNA binding Source: EcoliWiki

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12204-MONOMER.
ECOL316407:JW1812-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cold shock-like protein CspC
Short name:
CSP-C
Gene namesi
Name:cspC
Synonyms:msmB
Ordered Locus Names:b1823, JW1812
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12204. cspC.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved3 Publications
Chaini2 – 6968Cold shock-like protein CspCPRO_0000100241Add
BLAST

Proteomic databases

EPDiP0A9Y6.
PaxDbiP0A9Y6.
PRIDEiP0A9Y6.

2D gel databases

SWISS-2DPAGEP0A9Y6.

Interactioni

GO - Molecular functioni

  • chaperone binding Source: CACAO

Protein-protein interaction databases

BioGridi4263536. 349 interactions.
DIPiDIP-36183N.
IntActiP0A9Y6. 73 interactions.
MINTiMINT-1218847.
STRINGi511145.b1823.

Structurei

3D structure databases

ProteinModelPortaliP0A9Y6.
SMRiP0A9Y6. Positions 3-69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 6661CSDAdd
BLAST

Sequence similaritiesi

Contains 1 CSD (cold-shock) domain.Curated

Phylogenomic databases

eggNOGiCOG1278. LUCA.
HOGENOMiHOG000070674.
InParanoidiP0A9Y6.
KOiK03704.
OMAiFEIQDGH.
OrthoDBiEOG618R0J.
PhylomeDBiP0A9Y6.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR019844. Cold-shock_CS.
IPR012156. Cold_shock_CspA.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
[Graphical view]
PIRSFiPIRSF002599. Cold_shock_A. 1 hit.
PRINTSiPR00050. COLDSHOCK.
SMARTiSM00357. CSP. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS00352. COLD_SHOCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A9Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKIKGQVKW FNESKGFGFI TPADGSKDVF VHFSAIQGNG FKTLAEGQNV
60
EFEIQDGQKG PAAVNVTAI
Length:69
Mass (Da):7,402
Last modified:January 23, 2007 - v2
Checksum:i2A644A4C96F4B425
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71Q → T AA sequence (PubMed:9868784).Curated

Mass spectrometryi

Molecular mass is 7273 Da from positions 2 - 69. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28430 Genomic DNA. Translation: AAA23619.1.
D28496 Genomic DNA. Translation: BAA05854.1.
U00096 Genomic DNA. Translation: AAC74893.1.
AP009048 Genomic DNA. Translation: BAA15634.1.
PIRiS43618.
RefSeqiNP_416337.1. NC_000913.3.
WP_001062678.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74893; AAC74893; b1823.
BAA15634; BAA15634; BAA15634.
GeneIDi8911702.
946339.
KEGGiecj:JW1812.
eco:b1823.
PATRICi32118965. VBIEscCol129921_1900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28430 Genomic DNA. Translation: AAA23619.1.
D28496 Genomic DNA. Translation: BAA05854.1.
U00096 Genomic DNA. Translation: AAC74893.1.
AP009048 Genomic DNA. Translation: BAA15634.1.
PIRiS43618.
RefSeqiNP_416337.1. NC_000913.3.
WP_001062678.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0A9Y6.
SMRiP0A9Y6. Positions 3-69.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263536. 349 interactions.
DIPiDIP-36183N.
IntActiP0A9Y6. 73 interactions.
MINTiMINT-1218847.
STRINGi511145.b1823.

2D gel databases

SWISS-2DPAGEP0A9Y6.

Proteomic databases

EPDiP0A9Y6.
PaxDbiP0A9Y6.
PRIDEiP0A9Y6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74893; AAC74893; b1823.
BAA15634; BAA15634; BAA15634.
GeneIDi8911702.
946339.
KEGGiecj:JW1812.
eco:b1823.
PATRICi32118965. VBIEscCol129921_1900.

Organism-specific databases

EchoBASEiEB2120.
EcoGeneiEG12204. cspC.

Phylogenomic databases

eggNOGiCOG1278. LUCA.
HOGENOMiHOG000070674.
InParanoidiP0A9Y6.
KOiK03704.
OMAiFEIQDGH.
OrthoDBiEOG618R0J.
PhylomeDBiP0A9Y6.

Enzyme and pathway databases

BioCyciEcoCyc:EG12204-MONOMER.
ECOL316407:JW1812-MONOMER.

Miscellaneous databases

PROiP0A9Y6.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR019844. Cold-shock_CS.
IPR012156. Cold_shock_CspA.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
[Graphical view]
PIRSFiPIRSF002599. Cold_shock_A. 1 hit.
PRINTSiPR00050. COLDSHOCK.
SMARTiSM00357. CSP. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS00352. COLD_SHOCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Family of the major cold-shock protein, CspA (CS7.4), of Escherichia coli, whose members show a high sequence similarity with the eukaryotic Y-box binding proteins."
    Lee S.J., Xie A., Jiang W., Etchegaray J.-P., Jones P.G., Inouye M.
    Mol. Microbiol. 11:833-839(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: TAP90 / ATCC 47037.
  2. "Cloning, sequencing, and characterization of multicopy suppressors of a mukB mutation in Escherichia coli."
    Yamanaka K., Mitani T., Ogura T., Niki H., Hiraga S.
    Mol. Microbiol. 13:301-312(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. Cited for: PROTEIN SEQUENCE OF 2-13.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  7. "Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12."
    Link A.J., Robison K., Church G.M.
    Electrophoresis 18:1259-1313(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-13.
    Strain: K12 / EMG2.
  8. "Small genes/gene-products in Escherichia coli K-12."
    Wasinger V.C., Humphery-Smith I.
    FEMS Microbiol. Lett. 169:375-382(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-11.
    Strain: K12.
  9. "Gas-phase concentration, purification, and identification of whole proteins from complex mixtures."
    Reid G.E., Shang H., Hogan J.M., Lee G.U., McLuckey S.A.
    J. Am. Chem. Soc. 124:7353-7362(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: MASS SPECTROMETRY.
    Strain: ATCC 15597.

Entry informationi

Entry nameiCSPC_ECOLI
AccessioniPrimary (citable) accession number: P0A9Y6
Secondary accession number(s): O68636, P36996
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.