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Protein

Cold shock protein CspA

Gene

cspA

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Binds to and stimulates the transcription of the CCAAT-containing, cold-shock-inducible promoters of the H-NS and GyrA proteins. Binds also to the inverted repeat 5'-ATTGG-3' (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Stress response, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciECOL386585:GJFA-4407-MONOMER.
ECOO157:CSPA-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cold shock protein CspA
Short name:
CSP-A
Alternative name(s):
7.4 kDa cold shock protein
CS7.4
Gene namesi
Name:cspA
Ordered Locus Names:Z4981, ECs4441
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 7069Cold shock protein CspAPRO_0000100235Add
BLAST

Proteomic databases

PRIDEiP0A9Y1.

Expressioni

Inductioni

In response to low temperature.By similarity

Interactioni

Protein-protein interaction databases

MINTiMINT-1220123.
STRINGi155864.Z4981.

Structurei

3D structure databases

ProteinModelPortaliP0A9Y1.
SMRiP0A9Y1. Positions 2-70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 6761CSDAdd
BLAST

Sequence similaritiesi

Contains 1 CSD (cold-shock) domain.Curated

Phylogenomic databases

eggNOGiENOG4105VEQ. Bacteria.
COG1278. LUCA.
HOGENOMiHOG000070674.
KOiK03704.
OMAiAIQNEGY.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR019844. Cold-shock_CS.
IPR012156. Cold_shock_CspA.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
[Graphical view]
PIRSFiPIRSF002599. Cold_shock_A. 1 hit.
PRINTSiPR00050. COLDSHOCK.
SMARTiSM00357. CSP. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS00352. COLD_SHOCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A9Y1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGKMTGIVK WFNADKGFGF ITPDDGSKDV FVHFSAIQND GYKSLDEGQK
60 70
VSFTIESGAK GPAAGNVTSL
Length:70
Mass (Da):7,403
Last modified:January 23, 2007 - v2
Checksum:iCED47F00BF18A49B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG58705.1.
BA000007 Genomic DNA. Translation: BAB37864.1.
PIRiA91184.
E86030.
RefSeqiNP_312468.1. NC_002695.1.
WP_000014594.1. NZ_LPWC01000094.1.

Genome annotation databases

EnsemblBacteriaiAAG58705; AAG58705; Z4981.
BAB37864; BAB37864; BAB37864.
GeneIDi23335706.
915643.
KEGGiece:Z4981.
ecs:ECs4441.
PATRICi18358479. VBIEscCol44059_4405.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG58705.1.
BA000007 Genomic DNA. Translation: BAB37864.1.
PIRiA91184.
E86030.
RefSeqiNP_312468.1. NC_002695.1.
WP_000014594.1. NZ_LPWC01000094.1.

3D structure databases

ProteinModelPortaliP0A9Y1.
SMRiP0A9Y1. Positions 2-70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1220123.
STRINGi155864.Z4981.

Proteomic databases

PRIDEiP0A9Y1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG58705; AAG58705; Z4981.
BAB37864; BAB37864; BAB37864.
GeneIDi23335706.
915643.
KEGGiece:Z4981.
ecs:ECs4441.
PATRICi18358479. VBIEscCol44059_4405.

Phylogenomic databases

eggNOGiENOG4105VEQ. Bacteria.
COG1278. LUCA.
HOGENOMiHOG000070674.
KOiK03704.
OMAiAIQNEGY.

Enzyme and pathway databases

BioCyciECOL386585:GJFA-4407-MONOMER.
ECOO157:CSPA-MONOMER.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR019844. Cold-shock_CS.
IPR012156. Cold_shock_CspA.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
[Graphical view]
PIRSFiPIRSF002599. Cold_shock_A. 1 hit.
PRINTSiPR00050. COLDSHOCK.
SMARTiSM00357. CSP. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS00352. COLD_SHOCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSPA_ECO57
AccessioniPrimary (citable) accession number: P0A9Y1
Secondary accession number(s): P15277, P37410, Q54170
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.