Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Rod shape-determining protein MreB

Gene

mreB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in formation of the rod shape of the cell. May act as a negative regulator of FtsI. Polymerization and bundle formation is enhanced by CbeA.1 Publication

Enzyme regulationi

Polymerization is inhibited by toxins CbtA and CptA, as well as by A22 ([S-(3,4-dichlorobenzyl)isothiourea)] all of which cause cell rounding and eventual death. Inhibition by toxin CbtA is neutralized by cytoskeleton bundling-enhancing protein CbeA, inhibition by toxin CptA is neutralized by antitoxin CptB, while inhibition by A22 can be neutralized by overexpression of CbeA.3 Publications

GO - Molecular functioni

  • identical protein binding Source: EcoCyc

GO - Biological processi

  • cell morphogenesis Source: InterPro
  • FtsZ-dependent cytokinesis Source: EcoCyc
  • negative regulation of cell division Source: CACAO
  • regulation of cell shape Source: EcoCyc
  • regulation of chromosome segregation Source: EcoliWiki

Keywordsi

Biological processCell shape

Enzyme and pathway databases

BioCyciEcoCyc:EG10608-MONOMER

Protein family/group databases

TCDBi9.B.157.1.3 the cell shape-determining mrebcd (mrebcd) family

Names & Taxonomyi

Protein namesi
Recommended name:
Rod shape-determining protein MreB
Gene namesi
Name:mreB
Synonyms:envB, rodY
Ordered Locus Names:b3251, JW3220
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10608 mreB

Subcellular locationi

GO - Cellular componenti

  • cytoskeleton Source: EcoCyc
  • intrinsic component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000627591 – 347Rod shape-determining protein MreBAdd BLAST347

Proteomic databases

EPDiP0A9X4
PaxDbiP0A9X4
PRIDEiP0A9X4

Interactioni

Subunit structurei

Interacts with FtsZ, toxins CbtA and CptA, and cytoskeleton bundling-enhancing protein CbeA.3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4261940383 interactors.
DIPiDIP-31874N
IntActiP0A9X4 81 interactors.
MINTiP0A9X4
STRINGi316385.ECDH10B_3427

Structurei

3D structure databases

ProteinModelPortaliP0A9X4
SMRiP0A9X4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FtsA/MreB family.Curated

Phylogenomic databases

eggNOGiCOG1077 LUCA
HOGENOMiHOG000019757
InParanoidiP0A9X4
KOiK03569
OMAiMVICIPS
PhylomeDBiP0A9X4

Family and domain databases

CDDicd10225 MreB_like, 1 hit
InterProiView protein in InterPro
IPR004753 MreB
PANTHERiPTHR42749 PTHR42749, 1 hit
PfamiView protein in Pfam
PF06723 MreB_Mbl, 1 hit
PRINTSiPR01652 SHAPEPROTEIN
TIGRFAMsiTIGR00904 mreB, 1 hit

Sequencei

Sequence statusi: Complete.

P0A9X4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKKFRGMFS NDLSIDLGTA NTLIYVKGQG IVLNEPSVVA IRQDRAGSPK
60 70 80 90 100
SVAAVGHDAK QMLGRTPGNI AAIRPMKDGV IADFFVTEKM LQHFIKQVHS
110 120 130 140 150
NSFMRPSPRV LVCVPVGATQ VERRAIRESA QGAGAREVFL IEEPMAAAIG
160 170 180 190 200
AGLPVSEATG SMVVDIGGGT TEVAVISLNG VVYSSSVRIG GDRFDEAIIN
210 220 230 240 250
YVRRNYGSLI GEATAERIKH EIGSAYPGDE VREIEVRGRN LAEGVPRGFT
260 270 280 290 300
LNSNEILEAL QEPLTGIVSA VMVALEQCPP ELASDISERG MVLTGGGALL
310 320 330 340
RNLDRLLMEE TGIPVVVAED PLTCVARGGG KALEMIDMHG GDLFSEE
Length:347
Mass (Da):36,952
Last modified:September 13, 2005 - v1
Checksum:i1393696D8CDAEF93
GO

Sequence cautioni

The sequence AAA58054 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60 – 61KQ → NE in AAA83891 (PubMed:3049542).Curated2
Sequence conflicti265T → I in AAA83891 (PubMed:3049542).Curated1
Sequence conflicti277 – 278QC → HT in AAA83891 (PubMed:3049542).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22055 Genomic DNA Translation: AAA83891.1
U18997 Genomic DNA Translation: AAA58054.1 Different initiation.
U00096 Genomic DNA Translation: AAC76283.2
AP009048 Genomic DNA Translation: BAE77293.1
M31792 Genomic DNA Translation: AAA24154.1
RefSeqiNP_417717.2, NC_000913.3
WP_000913396.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76283; AAC76283; b3251
BAE77293; BAE77293; BAE77293
GeneIDi34152801
948588
KEGGiecj:JW3220
eco:b3251
PATRICifig|511145.12.peg.3348

Similar proteinsi

Entry informationi

Entry nameiMREB_ECOLI
AccessioniPrimary (citable) accession number: P0A9X4
Secondary accession number(s): P13519, P76678, Q2M8W3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome