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Protein

Zinc import ATP-binding protein ZnuC

Gene

znuC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system.UniRule annotation1 Publication

Enzyme regulationi

Inhibited by arsenate.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 448ATPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:ZNUC-MONOMER.
ECOL316407:JW1847-MONOMER.
MetaCyc:ZNUC-MONOMER.

Protein family/group databases

TCDBi3.A.1.15.5. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc import ATP-binding protein ZnuCUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:znuCUniRule annotation
Synonyms:yebM
Ordered Locus Names:b1858, JW1847
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13132. znuC.

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251Zinc import ATP-binding protein ZnuCPRO_0000093130Add
BLAST

Proteomic databases

PaxDbiP0A9X1.
PRIDEiP0A9X1.

Expressioni

Inductioni

Transcriptionally repressed by zur (zinc uptake regulator), in response to high extracellular zinc concentrations.2 Publications

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (ZnuC), two transmembrane proteins (ZnuB) and a solute-binding protein (ZnuA).UniRule annotation

Protein-protein interaction databases

DIPiDIP-48234N.
IntActiP0A9X1. 13 interactions.
STRINGi511145.b1858.

Structurei

3D structure databases

ProteinModelPortaliP0A9X1.
SMRiP0A9X1. Positions 5-230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 220216ABC transporterUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family. [View classification]UniRule annotation
Contains 1 ABC transporter domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105FDK. Bacteria.
COG1121. LUCA.
InParanoidiP0A9X1.
KOiK09817.
OMAiSNFAMHA.
OrthoDBiEOG6VXF80.
PhylomeDBiP0A9X1.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR027417. P-loop_NTPase.
IPR017882. ZnuC.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50893. ABC_TRANSPORTER_2. 1 hit.
PS51298. ZNUC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A9X1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSLVSLENV SVSFGQRRVL SDVSLELKPG KILTLLGPNG AGKSTLVRVV
60 70 80 90 100
LGLVTPDEGV IKRNGKLRIG YVPQKLYLDT TLPLTVNRFL RLRPGTHKED
110 120 130 140 150
ILPALKRVQA GHLINAPMQK LSGGETQRVL LARALLNRPQ LLVLDEPTQG
160 170 180 190 200
VDVNGQVALY DLIDQLRREL DCGVLMVSHD LHLVMAKTDE VLCLNHHICC
210 220 230 240 250
SGTPEVVSLH PEFISMFGPR GAEQLGIYRH HHNHRHDLQG RIVLRRGNDR

S
Length:251
Mass (Da):27,867
Last modified:July 19, 2005 - v1
Checksum:iF4BF845AC3C7904C
GO

Sequence cautioni

The sequence U38702 differs from that shown. Reason: Frameshift at position 188. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti80 – 834TTLP → STLS in U38702 (Ref. 1) Curated
Sequence conflicti135 – 1351L → W in U38702 (Ref. 1) Curated
Sequence conflicti143 – 1431V → A in U38702 (Ref. 1) Curated
Sequence conflicti155 – 1551G → W in U38702 (Ref. 1) Curated
Sequence conflicti174 – 1763VLM → ALL in U38702 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38702 Genomic DNA. No translation available.
U00096 Genomic DNA. Translation: AAC74928.1.
AP009048 Genomic DNA. Translation: BAA15666.1.
PIRiB64948.
RefSeqiNP_416372.1. NC_000913.3.
WP_000202996.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74928; AAC74928; b1858.
BAA15666; BAA15666; BAA15666.
GeneIDi946374.
KEGGiecj:JW1847.
eco:b1858.
PATRICi32119039. VBIEscCol129921_1937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38702 Genomic DNA. No translation available.
U00096 Genomic DNA. Translation: AAC74928.1.
AP009048 Genomic DNA. Translation: BAA15666.1.
PIRiB64948.
RefSeqiNP_416372.1. NC_000913.3.
WP_000202996.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0A9X1.
SMRiP0A9X1. Positions 5-230.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48234N.
IntActiP0A9X1. 13 interactions.
STRINGi511145.b1858.

Protein family/group databases

TCDBi3.A.1.15.5. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP0A9X1.
PRIDEiP0A9X1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74928; AAC74928; b1858.
BAA15666; BAA15666; BAA15666.
GeneIDi946374.
KEGGiecj:JW1847.
eco:b1858.
PATRICi32119039. VBIEscCol129921_1937.

Organism-specific databases

EchoBASEiEB2931.
EcoGeneiEG13132. znuC.

Phylogenomic databases

eggNOGiENOG4105FDK. Bacteria.
COG1121. LUCA.
InParanoidiP0A9X1.
KOiK09817.
OMAiSNFAMHA.
OrthoDBiEOG6VXF80.
PhylomeDBiP0A9X1.

Enzyme and pathway databases

BioCyciEcoCyc:ZNUC-MONOMER.
ECOL316407:JW1847-MONOMER.
MetaCyc:ZNUC-MONOMER.

Miscellaneous databases

PROiP0A9X1.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR027417. P-loop_NTPase.
IPR017882. ZnuC.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50893. ABC_TRANSPORTER_2. 1 hit.
PS51298. ZNUC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Robison K., O'Keeffe T., Church G.M.
    Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12 / EMG2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "The ZnuABC high-affinity zinc uptake system and its regulator Zur in Escherichia coli."
    Patzer S.I., Hantke K.
    Mol. Microbiol. 28:1199-1210(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN ZINC TRANSPORT, INDUCTION, ATPASE ACTIVITY, ENZYME REGULATION.
    Strain: K12.
  6. "Transcriptional response of Escherichia coli to external zinc."
    Yamamoto K., Ishihama A.
    J. Bacteriol. 187:6333-6340(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiZNUC_ECOLI
AccessioniPrimary (citable) accession number: P0A9X1
Secondary accession number(s): P52648, P76285
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 11, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.