Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

HTH-type transcriptional regulator UlaR

Gene

ulaR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Represses ulaG and the ulaABCDEF operon. Two ulaR binding sites have been identified in each promoter. Full activity requires simultaneous interaction of UlaR with both divergent promoters and seems to be dependent on repressor-mediated DNA loop formation, which is helped by the action of integration host factor.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi20 – 39H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: UniProtKB-HAMAP
  • L-ascorbic acid binding Source: EcoCyc
  • transcription factor activity, sequence-specific DNA binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7854-MONOMER.
ECOL316407:JW4149-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator UlaR
Gene namesi
Name:ulaR
Synonyms:yjfQ
Ordered Locus Names:b4191, JW4149
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12491. ulaR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene show a more rapid utilization of L-ascorbate and are able to grow on L-ascorbate under microaerophilic conditions.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000502771 – 251HTH-type transcriptional regulator UlaRAdd BLAST251

Proteomic databases

PaxDbiP0A9W0.
PRIDEiP0A9W0.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
groLP0A6F53EBI-560926,EBI-543750

Protein-protein interaction databases

BioGridi4262711. 9 interactors.
DIPiDIP-47874N.
IntActiP0A9W0. 40 interactors.
MINTiMINT-1221501.
STRINGi511145.b4191.

Structurei

3D structure databases

ProteinModelPortaliP0A9W0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 58HTH deoR-typeAdd BLAST56

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DW5. Bacteria.
COG1349. LUCA.
HOGENOMiHOG000224683.
KOiK03477.
OMAiDQEHESV.
PhylomeDBiP0A9W0.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_01563. HTH_type_UlaR. 1 hit.
InterProiIPR014036. DeoR_C.
IPR001034. DeoR_HTH.
IPR018356. Tscrpt_reg_HTH_DeoR_CS.
IPR023711. Tscrpt_reg_HTH_UlaR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00455. DeoRC. 1 hit.
PF08220. HTH_DeoR. 1 hit.
[Graphical view]
PRINTSiPR00037. HTHLACR.
SMARTiSM00420. HTH_DEOR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00894. HTH_DEOR_1. 1 hit.
PS51000. HTH_DEOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A9W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEAQRHQIL LEMLAQLGFV TVEKVVERLG ISPATARRDI NKLDESGKLK
60 70 80 90 100
KVRNGAEAIT QQRPRWTPMN LHQAQNHDEK VRIAKAASQL VNPGESVVIN
110 120 130 140 150
CGSTAFLLGR EMCGKPVQII TNYLPLANYL IDQEHDSVII MGGQYNKSQS
160 170 180 190 200
ITLSPQGSEN SLYAGHWMFT SGKGLTAEGL YKTDMLTAMA EQKMLSVVGK
210 220 230 240 250
LVVLVDSSKI GERAGMLFSR ADQIDMLITG KNANPEILQQ LEAQGVSILR

V
Length:251
Mass (Da):27,602
Last modified:July 19, 2005 - v1
Checksum:i797396226CFE01D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97087.1.
U00096 Genomic DNA. Translation: AAC77148.1.
AP009048 Genomic DNA. Translation: BAE78192.1.
AY625132 Genomic DNA. Translation: AAT42486.1.
PIRiS56416.
RefSeqiNP_418612.1. NC_000913.3.
WP_000133631.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77148; AAC77148; b4191.
BAE78192; BAE78192; BAE78192.
GeneIDi948706.
KEGGiecj:JW4149.
eco:b4191.
PATRICi32123957. VBIEscCol129921_4323.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97087.1.
U00096 Genomic DNA. Translation: AAC77148.1.
AP009048 Genomic DNA. Translation: BAE78192.1.
AY625132 Genomic DNA. Translation: AAT42486.1.
PIRiS56416.
RefSeqiNP_418612.1. NC_000913.3.
WP_000133631.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0A9W0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262711. 9 interactors.
DIPiDIP-47874N.
IntActiP0A9W0. 40 interactors.
MINTiMINT-1221501.
STRINGi511145.b4191.

Proteomic databases

PaxDbiP0A9W0.
PRIDEiP0A9W0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77148; AAC77148; b4191.
BAE78192; BAE78192; BAE78192.
GeneIDi948706.
KEGGiecj:JW4149.
eco:b4191.
PATRICi32123957. VBIEscCol129921_4323.

Organism-specific databases

EchoBASEiEB2384.
EcoGeneiEG12491. ulaR.

Phylogenomic databases

eggNOGiENOG4105DW5. Bacteria.
COG1349. LUCA.
HOGENOMiHOG000224683.
KOiK03477.
OMAiDQEHESV.
PhylomeDBiP0A9W0.

Enzyme and pathway databases

BioCyciEcoCyc:G7854-MONOMER.
ECOL316407:JW4149-MONOMER.

Miscellaneous databases

PROiP0A9W0.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_01563. HTH_type_UlaR. 1 hit.
InterProiIPR014036. DeoR_C.
IPR001034. DeoR_HTH.
IPR018356. Tscrpt_reg_HTH_DeoR_CS.
IPR023711. Tscrpt_reg_HTH_UlaR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00455. DeoRC. 1 hit.
PF08220. HTH_DeoR. 1 hit.
[Graphical view]
PRINTSiPR00037. HTHLACR.
SMARTiSM00420. HTH_DEOR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00894. HTH_DEOR_1. 1 hit.
PS51000. HTH_DEOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiULAR_ECOLI
AccessioniPrimary (citable) accession number: P0A9W0
Secondary accession number(s): P39299, Q2M6B4, Q6IU17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.