Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

HTH-type transcriptional regulator UlaR

Gene

ulaR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Represses ulaG and the ulaABCDEF operon. Two ulaR binding sites have been identified in each promoter. Full activity requires simultaneous interaction of UlaR with both divergent promoters and seems to be dependent on repressor-mediated DNA loop formation, which is helped by the action of integration host factor.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi20 – 39H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: InterPro
  • L-ascorbic acid binding Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G7854-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator UlaR
Gene namesi
Name:ulaR
Synonyms:yjfQ
Ordered Locus Names:b4191, JW4149
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12491 ulaR

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene show a more rapid utilization of L-ascorbate and are able to grow on L-ascorbate under microaerophilic conditions.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000502771 – 251HTH-type transcriptional regulator UlaRAdd BLAST251

Proteomic databases

PaxDbiP0A9W0
PRIDEiP0A9W0

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi4262711, 9 interactors
DIPiDIP-47874N
IntActiP0A9W0, 41 interactors
STRINGi316385.ECDH10B_4386

Structurei

3D structure databases

ProteinModelPortaliP0A9W0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 58HTH deoR-typeAdd BLAST56

Phylogenomic databases

eggNOGiENOG4105DW5 Bacteria
COG1349 LUCA
HOGENOMiHOG000224683
KOiK03477
OMAiFDNDVTR
PhylomeDBiP0A9W0

Family and domain databases

Gene3Di1.10.10.10, 1 hit
HAMAPiMF_01563 HTH_type_UlaR, 1 hit
InterProiView protein in InterPro
IPR014036 DeoR_C
IPR001034 DeoR_HTH
IPR037171 NagB/RpiA_transferase-like
IPR018356 Tscrpt_reg_HTH_DeoR_CS
IPR023711 Tscrpt_reg_HTH_UlaR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00455 DeoRC, 1 hit
PF08220 HTH_DeoR, 1 hit
PRINTSiPR00037 HTHLACR
SMARTiView protein in SMART
SM00420 HTH_DEOR, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
SSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00894 HTH_DEOR_1, 1 hit
PS51000 HTH_DEOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0A9W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEAQRHQIL LEMLAQLGFV TVEKVVERLG ISPATARRDI NKLDESGKLK
60 70 80 90 100
KVRNGAEAIT QQRPRWTPMN LHQAQNHDEK VRIAKAASQL VNPGESVVIN
110 120 130 140 150
CGSTAFLLGR EMCGKPVQII TNYLPLANYL IDQEHDSVII MGGQYNKSQS
160 170 180 190 200
ITLSPQGSEN SLYAGHWMFT SGKGLTAEGL YKTDMLTAMA EQKMLSVVGK
210 220 230 240 250
LVVLVDSSKI GERAGMLFSR ADQIDMLITG KNANPEILQQ LEAQGVSILR

V
Length:251
Mass (Da):27,602
Last modified:July 19, 2005 - v1
Checksum:i797396226CFE01D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97087.1
U00096 Genomic DNA Translation: AAC77148.1
AP009048 Genomic DNA Translation: BAE78192.1
AY625132 Genomic DNA Translation: AAT42486.1
PIRiS56416
RefSeqiNP_418612.1, NC_000913.3
WP_000133631.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77148; AAC77148; b4191
BAE78192; BAE78192; BAE78192
GeneIDi948706
KEGGiecj:JW4149
eco:b4191
PATRICifig|1411691.4.peg.2510

Similar proteinsi

Entry informationi

Entry nameiULAR_ECOLI
AccessioniPrimary (citable) accession number: P0A9W0
Secondary accession number(s): P39299, Q2M6B4, Q6IU17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: April 25, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health