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Protein

3-sulfolactaldehyde reductase

Gene

yihU

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Reduces 3-sulfolactaldehyde (SLA) to 2,3-dihydroxypropane 1-sulfonate (DHPS).UniRule annotation1 Publication

Catalytic activityi

2,3-dihydroxypropane-1-sulfonate + NAD+ = 2-hydroxy-3-oxopropane-1-sulfonate + NADH.UniRule annotation1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei96 – 961NADUniRule annotation
Active sitei171 – 1711UniRule annotation
Binding sitei240 – 2401NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi5 – 1915NADUniRule annotationAdd
BLAST

GO - Molecular functioni

  • 3-sulfolactaldehyde reductase activity Source: EcoCyc
  • 4-hydroxybutyrate dehydrogenase activity Source: EcoCyc
  • identical protein binding Source: EcoCyc
  • NAD binding Source: InterPro
  • phosphogluconate dehydrogenase (decarboxylating) activity Source: InterPro

GO - Biological processi

  • 6-sulfoquinovose(1-) catabolic process Source: EcoCyc
  • toxin catabolic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciECOL316407:JW3853-MONOMER.
BRENDAi1.1.1.61. 2026.

Names & Taxonomyi

Protein namesi
Recommended name:
3-sulfolactaldehyde reductaseUniRule annotation (EC:1.1.1.373UniRule annotation)
Short name:
SLA reductaseUniRule annotation
Gene namesi
Name:yihU
Ordered Locus Names:b3882, JW3853
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11847. yihU.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2982983-sulfolactaldehyde reductasePRO_0000173064Add
BLAST

Proteomic databases

PaxDbiP0A9V8.
PRIDEiP0A9V8.

Expressioni

Inductioni

Induced during growth with sulfoquinovose.1 Publication

Interactioni

GO - Molecular functioni

  • identical protein binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4260959. 7 interactions.
DIPiDIP-48142N.
IntActiP0A9V8. 7 interactions.
MINTiMINT-1289833.
STRINGi511145.b3882.

Structurei

3D structure databases

ProteinModelPortaliP0A9V8.
SMRiP0A9V8. Positions 4-282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-hydroxyisobutyrate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CF3. Bacteria.
COG2084. LUCA.
HOGENOMiHOG000219610.
InParanoidiP0A9V8.
KOiK08318.
OMAiPAGQHVE.
OrthoDBiEOG6XDH0X.
PhylomeDBiP0A9V8.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_01913. SLA_reductase.
InterProiIPR002204. 3-OH-isobutyrate_DH-rel_CS.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006115. 6PGDH_NADP-bd.
IPR015815. HIBADH-related.
IPR016040. NAD(P)-bd_dom.
IPR029154. NADP-bd.
IPR030876. SLA_reductase.
[Graphical view]
PfamiPF14833. NAD_binding_11. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000103. HIBADH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00895. 3_HYDROXYISOBUT_DH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A9V8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAIAFIGLG QMGSPMASNL LQQGHQLRVF DVNAEAVRHL VDKGATPAAN
60 70 80 90 100
PAQAAKDAEF IITMLPNGDL VRNVLFGENG VCEGLSTDAL VIDMSTIHPL
110 120 130 140 150
QTDKLIADMQ AKGFSMMDVP VGRTSANAIT GTLLLLAGGT AEQVERATPI
160 170 180 190 200
LMAMGSELIN AGGPGMGIRV KLINNYMSIA LNALSAEAAV LCEALNLPFD
210 220 230 240 250
VAVKVMSGTA AGKGHFTTSW PNKVLSGDLS PAFMIDLAHK DLGIALDVAN
260 270 280 290
QLHVPMPLGA ASREVYSQAR AAGRGRQDWS AILEQVRVSA GMTAKVKM
Length:298
Mass (Da):31,158
Last modified:July 19, 2005 - v1
Checksum:i74FBC8C09FA7881C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19201 Genomic DNA. Translation: AAB03015.1.
U00096 Genomic DNA. Translation: AAD13444.1.
AP009048 Genomic DNA. Translation: BAE77427.1.
PIRiS40826.
RefSeqiNP_418318.1. NC_000913.3.
WP_000718893.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAD13444; AAD13444; b3882.
BAE77427; BAE77427; BAE77427.
GeneIDi948372.
KEGGiecj:JW3853.
eco:b3882.
PATRICi32123267. VBIEscCol129921_3994.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19201 Genomic DNA. Translation: AAB03015.1.
U00096 Genomic DNA. Translation: AAD13444.1.
AP009048 Genomic DNA. Translation: BAE77427.1.
PIRiS40826.
RefSeqiNP_418318.1. NC_000913.3.
WP_000718893.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0A9V8.
SMRiP0A9V8. Positions 4-282.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260959. 7 interactions.
DIPiDIP-48142N.
IntActiP0A9V8. 7 interactions.
MINTiMINT-1289833.
STRINGi511145.b3882.

Proteomic databases

PaxDbiP0A9V8.
PRIDEiP0A9V8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD13444; AAD13444; b3882.
BAE77427; BAE77427; BAE77427.
GeneIDi948372.
KEGGiecj:JW3853.
eco:b3882.
PATRICi32123267. VBIEscCol129921_3994.

Organism-specific databases

EchoBASEiEB1793.
EcoGeneiEG11847. yihU.

Phylogenomic databases

eggNOGiENOG4105CF3. Bacteria.
COG2084. LUCA.
HOGENOMiHOG000219610.
InParanoidiP0A9V8.
KOiK08318.
OMAiPAGQHVE.
OrthoDBiEOG6XDH0X.
PhylomeDBiP0A9V8.

Enzyme and pathway databases

BioCyciECOL316407:JW3853-MONOMER.
BRENDAi1.1.1.61. 2026.

Miscellaneous databases

PROiP0A9V8.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_01913. SLA_reductase.
InterProiIPR002204. 3-OH-isobutyrate_DH-rel_CS.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006115. 6PGDH_NADP-bd.
IPR015815. HIBADH-related.
IPR016040. NAD(P)-bd_dom.
IPR029154. NADP-bd.
IPR030876. SLA_reductase.
[Graphical view]
PfamiPF14833. NAD_binding_11. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000103. HIBADH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00895. 3_HYDROXYISOBUT_DH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes."
    Plunkett G. III, Burland V., Daniels D.L., Blattner F.R.
    Nucleic Acids Res. 21:3391-3398(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Sulphoglycolysis in Escherichia coli K-12 closes a gap in the biogeochemical sulphur cycle."
    Denger K., Weiss M., Felux A.K., Schneider A., Mayer C., Spiteller D., Huhn T., Cook A.M., Schleheck D.
    Nature 507:114-117(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, INDUCTION, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: K12.

Entry informationi

Entry nameiSQUU_ECOLI
AccessioniPrimary (citable) accession number: P0A9V8
Secondary accession number(s): P32142, Q2M8H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: March 16, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.