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Protein

3-sulfolactaldehyde reductase

Gene

yihU

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reduces 3-sulfolactaldehyde (SLA) to 2,3-dihydroxypropane 1-sulfonate (DHPS).UniRule annotation1 Publication

Catalytic activityi

2,3-dihydroxypropane-1-sulfonate + NAD+ = 2-hydroxy-3-oxopropane-1-sulfonate + NADH.UniRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei96NADUniRule annotation1
Active sitei171UniRule annotation1
Binding sitei240NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi5 – 19NADUniRule annotationAdd BLAST15

GO - Molecular functioni

  • 3-sulfolactaldehyde reductase activity Source: EcoCyc
  • 4-hydroxybutyrate dehydrogenase activity Source: EcoCyc
  • identical protein binding Source: EcoCyc
  • NAD binding Source: InterPro
  • phosphogluconate dehydrogenase (decarboxylating) activity Source: InterPro

GO - Biological processi

  • 6-sulfoquinovose(1-) catabolic process Source: EcoCyc
  • toxin catabolic process Source: EcoCyc

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciEcoCyc:EG11847-MONOMER
MetaCyc:EG11847-MONOMER
BRENDAi1.1.1.61 2026

Names & Taxonomyi

Protein namesi
Recommended name:
3-sulfolactaldehyde reductaseUniRule annotation (EC:1.1.1.373UniRule annotation)
Short name:
SLA reductaseUniRule annotation
Gene namesi
Name:yihU
Ordered Locus Names:b3882, JW3853
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11847 yihU

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001730641 – 2983-sulfolactaldehyde reductaseAdd BLAST298

Proteomic databases

PaxDbiP0A9V8
PRIDEiP0A9V8

Expressioni

Inductioni

Induced during growth with sulfoquinovose.1 Publication

Interactioni

GO - Molecular functioni

  • identical protein binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4260959, 7 interactors
DIPiDIP-48142N
IntActiP0A9V8, 7 interactors
STRINGi316385.ECDH10B_4072

Structurei

3D structure databases

ProteinModelPortaliP0A9V8
SMRiP0A9V8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-hydroxyisobutyrate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CF3 Bacteria
COG2084 LUCA
HOGENOMiHOG000219610
InParanoidiP0A9V8
KOiK08318
OMAiWPSEVNN
PhylomeDBiP0A9V8

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
HAMAPiMF_01913 SLA_reductase, 1 hit
InterProiView protein in InterPro
IPR002204 3-OH-isobutyrate_DH-rel_CS
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006115 6PGDH_NADP-bd
IPR015815 HIBADH-related
IPR036291 NAD(P)-bd_dom_sf
IPR029154 NADP-bd
IPR030876 SLA_reductase
PfamiView protein in Pfam
PF14833 NAD_binding_11, 1 hit
PF03446 NAD_binding_2, 1 hit
PIRSFiPIRSF000103 HIBADH, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00895 3_HYDROXYISOBUT_DH, 1 hit

Sequencei

Sequence statusi: Complete.

P0A9V8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAIAFIGLG QMGSPMASNL LQQGHQLRVF DVNAEAVRHL VDKGATPAAN
60 70 80 90 100
PAQAAKDAEF IITMLPNGDL VRNVLFGENG VCEGLSTDAL VIDMSTIHPL
110 120 130 140 150
QTDKLIADMQ AKGFSMMDVP VGRTSANAIT GTLLLLAGGT AEQVERATPI
160 170 180 190 200
LMAMGSELIN AGGPGMGIRV KLINNYMSIA LNALSAEAAV LCEALNLPFD
210 220 230 240 250
VAVKVMSGTA AGKGHFTTSW PNKVLSGDLS PAFMIDLAHK DLGIALDVAN
260 270 280 290
QLHVPMPLGA ASREVYSQAR AAGRGRQDWS AILEQVRVSA GMTAKVKM
Length:298
Mass (Da):31,158
Last modified:July 19, 2005 - v1
Checksum:i74FBC8C09FA7881C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19201 Genomic DNA Translation: AAB03015.1
U00096 Genomic DNA Translation: AAD13444.1
AP009048 Genomic DNA Translation: BAE77427.1
PIRiS40826
RefSeqiNP_418318.1, NC_000913.3
WP_000718893.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAD13444; AAD13444; b3882
BAE77427; BAE77427; BAE77427
GeneIDi948372
KEGGiecj:JW3853
eco:b3882
PATRICifig|1411691.4.peg.2829

Similar proteinsi

Entry informationi

Entry nameiSQUU_ECOLI
AccessioniPrimary (citable) accession number: P0A9V8
Secondary accession number(s): P32142, Q2M8H9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health