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Protein

HTH-type transcriptional regulator PuuR

Gene

puuR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Represses puuA, puuD and puuP.2 Publications

Pathwayi: putrescine degradation

This protein regulates the pathway putrescine degradation, which is part of Amine and polyamine degradation.
View all proteins of this organism that are known to be involved in the pathway putrescine degradation and in Amine and polyamine degradation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi23 – 42H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: EcoCyc
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • putrescine catabolic process Source: UniProtKB-UniPathway
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12431-MONOMER.
ECOL316407:JW1292-MONOMER.
UniPathwayiUPA00188.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator PuuR
Gene namesi
Name:puuR
Synonyms:ycjC
Ordered Locus Names:b1299, JW1292
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12431. puuR.

Pathology & Biotechi

Disruption phenotypei

Cells enhance strongly the transcription of puuE.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001497311 – 185HTH-type transcriptional regulator PuuRAdd BLAST185

Proteomic databases

PaxDbiP0A9U6.
PRIDEiP0A9U6.

Interactioni

Protein-protein interaction databases

BioGridi4263529. 9 interactors.
DIPiDIP-48257N.
IntActiP0A9U6. 1 interactor.
MINTiMINT-1257910.
STRINGi511145.b1299.

Structurei

3D structure databases

ProteinModelPortaliP0A9U6.
SMRiP0A9U6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 66HTH cro/C1-typePROSITE-ProRule annotationAdd BLAST55

Sequence similaritiesi

Contains 1 HTH cro/C1-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4107VRI. Bacteria.
ENOG4111ISD. LUCA.
HOGENOMiHOG000263463.
InParanoidiP0A9U6.
KOiK14056.
OMAiSMKLIHN.
PhylomeDBiP0A9U6.

Family and domain databases

Gene3Di1.10.260.40. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR001387. Cro/C1-type_HTH.
IPR013096. Cupin_2.
IPR010982. Lambda_DNA-bd_dom.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF07883. Cupin_2. 1 hit.
PF01381. HTH_3. 1 hit.
[Graphical view]
SMARTiSM00530. HTH_XRE. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF51182. SSF51182. 1 hit.
PROSITEiPS50943. HTH_CROC1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A9U6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDEGLAPGK RLSEIRQQQG LSQRRAAELS GLTHSAISTI EQDKVSPAIS
60 70 80 90 100
TLQKLLKVYG LSLSEFFSEP EKPDEPQVVI NQDDLIEMGS QGVSMKLVHN
110 120 130 140 150
GNPNRTLAMI FETYQPGTTT GERIKHQGEE IGTVLEGEIV LTINGQDYHL
160 170 180
VAGQSYAINT GIPHSFSNTS AGICRIISAH TPTTF
Length:185
Mass (Da):20,092
Last modified:July 19, 2005 - v1
Checksum:iD7D0D3FD794A7768
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74381.1.
AP009048 Genomic DNA. Translation: BAA14868.1.
M38433 Genomic DNA. No translation available.
PIRiF64878.
RefSeqiNP_415815.1. NC_000913.3.
WP_001278727.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74381; AAC74381; b1299.
BAA14868; BAA14868; BAA14868.
GeneIDi945886.
KEGGiecj:JW1292.
eco:b1299.
PATRICi32117870. VBIEscCol129921_1355.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74381.1.
AP009048 Genomic DNA. Translation: BAA14868.1.
M38433 Genomic DNA. No translation available.
PIRiF64878.
RefSeqiNP_415815.1. NC_000913.3.
WP_001278727.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0A9U6.
SMRiP0A9U6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263529. 9 interactors.
DIPiDIP-48257N.
IntActiP0A9U6. 1 interactor.
MINTiMINT-1257910.
STRINGi511145.b1299.

Proteomic databases

PaxDbiP0A9U6.
PRIDEiP0A9U6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74381; AAC74381; b1299.
BAA14868; BAA14868; BAA14868.
GeneIDi945886.
KEGGiecj:JW1292.
eco:b1299.
PATRICi32117870. VBIEscCol129921_1355.

Organism-specific databases

EchoBASEiEB2327.
EcoGeneiEG12431. puuR.

Phylogenomic databases

eggNOGiENOG4107VRI. Bacteria.
ENOG4111ISD. LUCA.
HOGENOMiHOG000263463.
InParanoidiP0A9U6.
KOiK14056.
OMAiSMKLIHN.
PhylomeDBiP0A9U6.

Enzyme and pathway databases

UniPathwayiUPA00188.
BioCyciEcoCyc:EG12431-MONOMER.
ECOL316407:JW1292-MONOMER.

Miscellaneous databases

PROiP0A9U6.

Family and domain databases

Gene3Di1.10.260.40. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR001387. Cro/C1-type_HTH.
IPR013096. Cupin_2.
IPR010982. Lambda_DNA-bd_dom.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF07883. Cupin_2. 1 hit.
PF01381. HTH_3. 1 hit.
[Graphical view]
SMARTiSM00530. HTH_XRE. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF51182. SSF51182. 1 hit.
PROSITEiPS50943. HTH_CROC1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPUUR_ECOLI
AccessioniPrimary (citable) accession number: P0A9U6
Secondary accession number(s): P38522, P76839, P77417
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.