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Protein

Protein tas

Gene

tas

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei53Proton donor1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi234 – 244NADP1 PublicationAdd BLAST11

GO - Molecular functioni

  • aldo-keto reductase (NADP) activity Source: EcoCyc

GO - Biological processi

  • cellular response to amino acid starvation Source: EcoliWiki
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciEcoCyc:G7462-MONOMER.
ECOL316407:JW2802-MONOMER.

Protein family/group databases

TCDBi8.A.5.1.5. the voltage-gated k(+) channel -subunit (kv) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein tas
Gene namesi
Name:tas
Synonyms:ygdS
Ordered Locus Names:b2834, JW2802
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13093. tas.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000703861 – 346Protein tasAdd BLAST346

Proteomic databases

EPDiP0A9T4.
PaxDbiP0A9T4.
PRIDEiP0A9T4.

Interactioni

Protein-protein interaction databases

BioGridi4263141. 8 interactors.
DIPiDIP-48107N.
IntActiP0A9T4. 2 interactors.
STRINGi511145.b2834.

Structurei

Secondary structure

1346
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Beta strandi12 – 19Combined sources8
Turni24 – 26Combined sources3
Helixi29 – 41Combined sources13
Beta strandi46 – 48Combined sources3
Beta strandi54 – 56Combined sources3
Turni59 – 63Combined sources5
Helixi64 – 76Combined sources13
Helixi79 – 81Combined sources3
Beta strandi83 – 88Combined sources6
Helixi107 – 121Combined sources15
Beta strandi126 – 131Combined sources6
Helixi157 – 169Combined sources13
Beta strandi172 – 180Combined sources9
Helixi183 – 196Combined sources14
Beta strandi203 – 207Combined sources5
Helixi215 – 226Combined sources12
Beta strandi229 – 233Combined sources5
Helixi237 – 242Combined sources6
Turni243 – 245Combined sources3
Helixi246 – 248Combined sources3
Helixi255 – 258Combined sources4
Helixi268 – 283Combined sources16
Helixi288 – 297Combined sources10
Beta strandi302 – 307Combined sources6
Helixi312 – 319Combined sources8
Helixi320 – 323Combined sources4
Helixi328 – 340Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LQAX-ray1.60A/B1-346[»]
ProteinModelPortaliP0A9T4.
SMRiP0A9T4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A9T4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CPC. Bacteria.
COG0667. LUCA.
HOGENOMiHOG000250270.
InParanoidiP0A9T4.
OMAiFGKLGYQ.
PhylomeDBiP0A9T4.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A9T4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQYHRIPHSS LEVSTLGLGT MTFGEQNSEA DAHAQLDYAV AQGINLIDVA
60 70 80 90 100
EMYPVPPRPE TQGLTETYVG NWLAKHGSRE KLIIASKVSG PSRNNDKGIR
110 120 130 140 150
PDQALDRKNI REALHDSLKR LQTDYLDLYQ VHWPQRPTNC FGKLGYSWTD
160 170 180 190 200
SAPAVSLLDT LDALAEYQRA GKIRYIGVSN ETAFGVMRYL HLADKHDLPR
210 220 230 240 250
IVTIQNPYSL LNRSFEVGLA EVSQYEGVEL LAYSCLGFGT LTGKYLNGAK
260 270 280 290 300
PAGARNTLFS RFTRYSGEQT QKAVAAYVDI ARRHGLDPAQ MALAFVRRQP
310 320 330 340
FVASTLLGAT TMDQLKTNIE SLHLELSEDV LAEIEAVHQV YTYPAP
Length:346
Mass (Da):38,500
Last modified:July 19, 2005 - v1
Checksum:i111692D06CA07CD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14609 Genomic DNA. Translation: CAA74961.1.
U29581 Genomic DNA. Translation: AAB40481.1.
U00096 Genomic DNA. Translation: AAC75873.1.
AP009048 Genomic DNA. Translation: BAE76903.1.
PIRiC65066.
RefSeqiNP_417311.1. NC_000913.3.
WP_001199295.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75873; AAC75873; b2834.
BAE76903; BAE76903; BAE76903.
GeneIDi947306.
KEGGiecj:JW2802.
eco:b2834.
PATRICi32121086. VBIEscCol129921_2932.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14609 Genomic DNA. Translation: CAA74961.1.
U29581 Genomic DNA. Translation: AAB40481.1.
U00096 Genomic DNA. Translation: AAC75873.1.
AP009048 Genomic DNA. Translation: BAE76903.1.
PIRiC65066.
RefSeqiNP_417311.1. NC_000913.3.
WP_001199295.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LQAX-ray1.60A/B1-346[»]
ProteinModelPortaliP0A9T4.
SMRiP0A9T4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263141. 8 interactors.
DIPiDIP-48107N.
IntActiP0A9T4. 2 interactors.
STRINGi511145.b2834.

Protein family/group databases

TCDBi8.A.5.1.5. the voltage-gated k(+) channel -subunit (kv) family.

Proteomic databases

EPDiP0A9T4.
PaxDbiP0A9T4.
PRIDEiP0A9T4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75873; AAC75873; b2834.
BAE76903; BAE76903; BAE76903.
GeneIDi947306.
KEGGiecj:JW2802.
eco:b2834.
PATRICi32121086. VBIEscCol129921_2932.

Organism-specific databases

EchoBASEiEB2898.
EcoGeneiEG13093. tas.

Phylogenomic databases

eggNOGiENOG4105CPC. Bacteria.
COG0667. LUCA.
HOGENOMiHOG000250270.
InParanoidiP0A9T4.
OMAiFGKLGYQ.
PhylomeDBiP0A9T4.

Enzyme and pathway databases

BioCyciEcoCyc:G7462-MONOMER.
ECOL316407:JW2802-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0A9T4.
PROiP0A9T4.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTAS_ECOLI
AccessioniPrimary (citable) accession number: P0A9T4
Secondary accession number(s): Q2MA03, Q46933
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.