ID   FUCO_ECO57              Reviewed;         383 AA.
AC   P0A9S2; P11549;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   16-JUN-2009, entry version 28.
DE   RecName: Full=Lactaldehyde reductase;
DE            EC=1.1.1.77;
DE   AltName: Full=Propanediol oxidoreductase;
GN   Name=fucO; OrderedLocusNames=Z4116, ECs3659;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   MEDLINE=21074935; PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   MEDLINE=21156231; PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- CATALYTIC ACTIVITY: (R)-propane-1,2-diol + NAD(+) = (R)-
CC       lactaldehyde + NADH.
CC   -!- CATALYTIC ACTIVITY: (S)-propane-1,2-diol + NAD(+) = (S)-
CC       lactaldehyde + NADH.
CC   -!- COFACTOR: Iron (Potential).
CC   -!- PATHWAY: Carbohydrate degradation; L-fucose degradation.
CC   -!- SIMILARITY: Belongs to the iron-containing alcohol dehydrogenase
CC       family.
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DR   EMBL; AE005174; AAG57913.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37082.1; -; Genomic_DNA.
DR   PIR; C91086; C91086.
DR   PIR; E85931; E85931.
DR   RefSeq; NP_289354.1; -.
DR   RefSeq; NP_311686.1; -.
DR   SMR; P0A9S2; 2-383.
DR   GeneID; 916534; -.
DR   GeneID; 958299; -.
DR   GenomeReviews; AE005174_GR; Z4116.
DR   GenomeReviews; BA000007_GR; ECs3659.
DR   KEGG; ece:Z4116; -.
DR   KEGG; ecs:ECs3659; -.
DR   HOGENOM; P0A9S2; -.
DR   OMA; P0A9S2; HDIPIVA.
DR   BioCyc; ECOL83334:ECS3659-MON; -.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008912; F:lactaldehyde reductase activity; IEA:EC.
DR   GO; GO:0006004; P:fucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001670; ADH_Fe.
DR   InterPro; IPR018211; ADH_Fe_CS.
DR   InterPro; IPR013460; Lactal_redase.
DR   Pfam; PF00465; Fe-ADH; 1.
DR   TIGRFAMs; TIGR02638; lactal_redase; 1.
DR   PROSITE; PS00913; ADH_IRON_1; 1.
DR   PROSITE; PS00060; ADH_IRON_2; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Fucose metabolism; Iron;
KW   NAD; Oxidoreductase.
FT   CHAIN         1    383       Lactaldehyde reductase.
FT                                /FTId=PRO_0000087825.
SQ   SEQUENCE   383 AA;  40645 MW;  F0103FED90CA33F3 CRC64;
     MMANRMILNE TAWFGRGAVG ALTDEVKRRG YQKALIVTDK TLVQCGVVAK VTDKMDAAGL
     AWAIYDGVVP NPTITVVKEG LGVFQNSGAD YLIAIGGGSP QDTCKAIGII SNNPEFADVR
     SLEGLSPTNK PSVPILAIPT TAGTAAEVTI NYVITDEEKR RKFVCVDPHD IPQVAFIDAD
     MMDGMPPALK AATGVDALTH AIEGYITRGA WALTDALHIK AIEIIAGALR GSVAGDKDAG
     EEMALGQYVA GMGFSNVGLG LVHGMAHPLG AFYNTPHGVA NAILLPHVMR YNADFTGEKY
     RDIARVMGVK VEGMSLEEAR NAAVEAVFAL NRDVGIPPHL RDVGVRKEDI PALAQAALDD
     VCTGGNPREA TLEDIVELYH TAW
//