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P0A9S2

- FUCO_ECO57

UniProt

P0A9S2 - FUCO_ECO57

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Protein
Lactaldehyde reductase
Gene
fucO, Z4116, ECs3659
Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(R)-propane-1,2-diol + NAD+ = (R)-lactaldehyde + NADH.
(S)-propane-1,2-diol + NAD+ = (S)-lactaldehyde + NADH.

Cofactori

Iron By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381NAD By similarity
Binding sitei70 – 701NAD By similarity
Binding sitei150 – 1501NAD By similarity
Binding sitei161 – 1611NAD By similarity
Metal bindingi195 – 1951Iron By similarity
Metal bindingi199 – 1991Iron; via tele nitrogen By similarity
Metal bindingi262 – 2621Iron; via tele nitrogen By similarity
Metal bindingi276 – 2761Iron; via tele nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi97 – 982NAD By similarity
Nucleotide bindingi139 – 1435NAD By similarity
Nucleotide bindingi180 – 1845NAD By similarity

GO - Molecular functioni

  1. lactaldehyde reductase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. fucose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism

Keywords - Ligandi

Iron, Metal-binding, NAD

Enzyme and pathway databases

BioCyciECOL386585:GJFA-3623-MONOMER.
UniPathwayiUPA00563.

Names & Taxonomyi

Protein namesi
Recommended name:
Lactaldehyde reductase (EC:1.1.1.77)
Alternative name(s):
Propanediol oxidoreductase
Gene namesi
Name:fucO
Ordered Locus Names:Z4116, ECs3659
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Lactaldehyde reductase
PRO_0000087825Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi155864.Z4116.

Structurei

3D structure databases

ProteinModelPortaliP0A9S2.
SMRiP0A9S2. Positions 1-382.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1454.
HOGENOMiHOG000243333.
KOiK00048.
OMAiDIVGLYQ.
OrthoDBiEOG6TFCQS.

Family and domain databases

InterProiIPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
IPR013460. Lactal_redase.
[Graphical view]
PfamiPF00465. Fe-ADH. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02638. lactal_redase. 1 hit.
PROSITEiPS00913. ADH_IRON_1. 1 hit.
PS00060. ADH_IRON_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A9S2-1 [UniParc]FASTAAdd to Basket

« Hide

MANRMILNET AWFGRGAVGA LTDEVKRRGY QKALIVTDKT LVQCGVVAKV    50
TDKMDAAGLA WAIYDGVVPN PTITVVKEGL GVFQNSGADY LIAIGGGSPQ 100
DTCKAIGIIS NNPEFADVRS LEGLSPTNKP SVPILAIPTT AGTAAEVTIN 150
YVITDEEKRR KFVCVDPHDI PQVAFIDADM MDGMPPALKA ATGVDALTHA 200
IEGYITRGAW ALTDALHIKA IEIIAGALRG SVAGDKDAGE EMALGQYVAG 250
MGFSNVGLGL VHGMAHPLGA FYNTPHGVAN AILLPHVMRY NADFTGEKYR 300
DIARVMGVKV EGMSLEEARN AAVEAVFALN RDVGIPPHLR DVGVRKEDIP 350
ALAQAALDDV CTGGNPREAT LEDIVELYHT AW 382
Length:382
Mass (Da):40,513
Last modified:November 16, 2011 - v2
Checksum:iE4D927AC8142098B
GO

Sequence cautioni

The sequence AAG57913.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence BAB37082.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG57913.1. Different initiation.
BA000007 Genomic DNA. Translation: BAB37082.1. Different initiation.
PIRiC91086.
E85931.
RefSeqiNP_289354.1. NC_002655.2.
NP_311686.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG57913; AAG57913; Z4116.
BAB37082; BAB37082; BAB37082.
GeneIDi916534.
958299.
KEGGiece:Z4116.
ecs:ECs3659.
PATRICi18356797. VBIEscCol44059_3581.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG57913.1 . Different initiation.
BA000007 Genomic DNA. Translation: BAB37082.1 . Different initiation.
PIRi C91086.
E85931.
RefSeqi NP_289354.1. NC_002655.2.
NP_311686.1. NC_002695.1.

3D structure databases

ProteinModelPortali P0A9S2.
SMRi P0A9S2. Positions 1-382.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 155864.Z4116.

Protocols and materials databases

DNASUi 958299.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG57913 ; AAG57913 ; Z4116 .
BAB37082 ; BAB37082 ; BAB37082 .
GeneIDi 916534.
958299.
KEGGi ece:Z4116.
ecs:ECs3659.
PATRICi 18356797. VBIEscCol44059_3581.

Phylogenomic databases

eggNOGi COG1454.
HOGENOMi HOG000243333.
KOi K00048.
OMAi DIVGLYQ.
OrthoDBi EOG6TFCQS.

Enzyme and pathway databases

UniPathwayi UPA00563 .
BioCyci ECOL386585:GJFA-3623-MONOMER.

Family and domain databases

InterProi IPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
IPR013460. Lactal_redase.
[Graphical view ]
Pfami PF00465. Fe-ADH. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02638. lactal_redase. 1 hit.
PROSITEi PS00913. ADH_IRON_1. 1 hit.
PS00060. ADH_IRON_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiFUCO_ECO57
AccessioniPrimary (citable) accession number: P0A9S2
Secondary accession number(s): P11549
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: November 16, 2011
Last modified: May 14, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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