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Reviewed, UniProtKB/Swiss-Prot P0A9S2 (FUCO_ECO57)

Last modified November 4, 2008. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Lactaldehyde reductase
    EC=1.1.1.77
Alternative name(s):
    Propanediol oxidoreductase
Gene names
Name: fucO
Ordered Locus Names: Z4116, ECs3659
OrganismEscherichia coli O157:H7 [Complete proteome] [HAMAP]
Taxonomic identifier83334 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length383 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

(R)-propane-1,2-diol + NAD(+) = (R)-lactaldehyde + NADH.

(S)-propane-1,2-diol + NAD(+) = (S)-lactaldehyde + NADH.

Cofactor

Iron Potential.

Pathway

Carbohydrate degradation; L-fucose degradation.

Sequence similarities

Belongs to the iron-containing alcohol dehydrogenase family.

Ontologies

Keywords

   Biological processCarbohydrate metabolism
Fucose metabolism
   LigandIron
NAD
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processfucose metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioniron ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

lactaldehyde reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 383383Lactaldehyde reductase
PRO_0000087825

Sequences

Sequence LengthMass (Da)Tools
P0A9S2-1 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: F0103FED90CA33F3

FASTA38340,645
        10         20         30         40         50         60 
MMANRMILNE TAWFGRGAVG ALTDEVKRRG YQKALIVTDK TLVQCGVVAK VTDKMDAAGL 

        70         80         90        100        110        120 
AWAIYDGVVP NPTITVVKEG LGVFQNSGAD YLIAIGGGSP QDTCKAIGII SNNPEFADVR 

       130        140        150        160        170        180 
SLEGLSPTNK PSVPILAIPT TAGTAAEVTI NYVITDEEKR RKFVCVDPHD IPQVAFIDAD 

       190        200        210        220        230        240 
MMDGMPPALK AATGVDALTH AIEGYITRGA WALTDALHIK AIEIIAGALR GSVAGDKDAG 

       250        260        270        280        290        300 
EEMALGQYVA GMGFSNVGLG LVHGMAHPLG AFYNTPHGVA NAILLPHVMR YNADFTGEKY 

       310        320        330        340        350        360 
RDIARVMGVK VEGMSLEEAR NAAVEAVFAL NRDVGIPPHL RDVGVRKEDI PALAQAALDD 

       370        380 
VCTGGNPREA TLEDIVELYH TAW 

« Hide

References

Cross-references

Sequence databases

AE005174 Genomic DNA. Translation: AAG57913.1.
BA000007 Genomic DNA. Translation: BAB37082.1.
PIRC91086.
E85931.
RefSeqNP_289354.1.
NP_311686.1.

3D structure databases

SMRP0A9S2. Positions 2-383.
ModBaseSearch...

Genome annotation databases

GeneID916534.
958299.
GenomeReviewsGene locus ECs3659 in contig BA000007_GR.
Gene locus Z4116 in contig AE005174_GR.
KEGGece:Z4116.
ecs:ECs3659.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP0A9S2.

Enzyme and pathway databases

BioCycECOL83334:ECS3659-MON.

Family and domain databases

InterProIPR001670. Fe_AlcDHase.
IPR013460. Lactal_redase.
[Graphical view]
PfamPF00465. Fe-ADH. 1 hit.
[Graphical view]
TIGRFAMsTIGR02638. lactal_redase. 1 hit.
PROSITEPS00913. ADH_IRON_1. 1 hit.
PS00060. ADH_IRON_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFUCO_ECO57
AccessionPrimary (citable) accession number: P0A9S2
Secondary accession number(s): P11549
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 4, 2008
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents