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Protein

Lactaldehyde reductase

Gene

fucO

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(R)-propane-1,2-diol + NAD+ = (R)-lactaldehyde + NADH.
(S)-propane-1,2-diol + NAD+ = (S)-lactaldehyde + NADH.

Cofactori

Fe cationBy similarity

Pathwayi: L-fucose degradation

This protein is involved in the pathway L-fucose degradation, which is part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the pathway L-fucose degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38NADBy similarity1
Binding sitei70NADBy similarity1
Binding sitei150NADBy similarity1
Binding sitei161NADBy similarity1
Metal bindingi195IronBy similarity1
Metal bindingi199Iron; via tele nitrogenBy similarity1
Metal bindingi262Iron; via tele nitrogenBy similarity1
Metal bindingi276Iron; via tele nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 98NADBy similarity2
Nucleotide bindingi139 – 143NADBy similarity5
Nucleotide bindingi180 – 184NADBy similarity5

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism

Keywords - Ligandi

Iron, Metal-binding, NAD

Enzyme and pathway databases

UniPathwayiUPA00563.

Names & Taxonomyi

Protein namesi
Recommended name:
Lactaldehyde reductase (EC:1.1.1.77)
Alternative name(s):
Propanediol oxidoreductase
Gene namesi
Name:fucO
Ordered Locus Names:Z4116, ECs3659
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878251 – 382Lactaldehyde reductaseAdd BLAST382

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi155864.Z4116.

Structurei

3D structure databases

ProteinModelPortaliP0A9S2.
SMRiP0A9S2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C0A. Bacteria.
COG1454. LUCA.
HOGENOMiHOG000243333.
KOiK00048.
OMAiDIVGLYQ.

Family and domain databases

InterProiIPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
IPR013460. Lactal_redase.
[Graphical view]
PfamiPF00465. Fe-ADH. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02638. lactal_redase. 1 hit.
PROSITEiPS00913. ADH_IRON_1. 1 hit.
PS00060. ADH_IRON_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A9S2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANRMILNET AWFGRGAVGA LTDEVKRRGY QKALIVTDKT LVQCGVVAKV
60 70 80 90 100
TDKMDAAGLA WAIYDGVVPN PTITVVKEGL GVFQNSGADY LIAIGGGSPQ
110 120 130 140 150
DTCKAIGIIS NNPEFADVRS LEGLSPTNKP SVPILAIPTT AGTAAEVTIN
160 170 180 190 200
YVITDEEKRR KFVCVDPHDI PQVAFIDADM MDGMPPALKA ATGVDALTHA
210 220 230 240 250
IEGYITRGAW ALTDALHIKA IEIIAGALRG SVAGDKDAGE EMALGQYVAG
260 270 280 290 300
MGFSNVGLGL VHGMAHPLGA FYNTPHGVAN AILLPHVMRY NADFTGEKYR
310 320 330 340 350
DIARVMGVKV EGMSLEEARN AAVEAVFALN RDVGIPPHLR DVGVRKEDIP
360 370 380
ALAQAALDDV CTGGNPREAT LEDIVELYHT AW
Length:382
Mass (Da):40,513
Last modified:November 16, 2011 - v2
Checksum:iE4D927AC8142098B
GO

Sequence cautioni

The sequence AAG57913 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB37082 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57913.1. Different initiation.
BA000007 Genomic DNA. Translation: BAB37082.1. Different initiation.
PIRiC91086.
E85931.
RefSeqiNP_311686.1. NC_002695.1.
WP_000013588.1. NZ_LPWC02000002.1.

Genome annotation databases

EnsemblBacteriaiAAG57913; AAG57913; Z4116.
BAB37082; BAB37082; BAB37082.
GeneIDi916534.
KEGGiece:Z4116.
ecs:ECs3659.
PATRICi18356797. VBIEscCol44059_3581.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57913.1. Different initiation.
BA000007 Genomic DNA. Translation: BAB37082.1. Different initiation.
PIRiC91086.
E85931.
RefSeqiNP_311686.1. NC_002695.1.
WP_000013588.1. NZ_LPWC02000002.1.

3D structure databases

ProteinModelPortaliP0A9S2.
SMRiP0A9S2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z4116.

Protocols and materials databases

DNASUi958299.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG57913; AAG57913; Z4116.
BAB37082; BAB37082; BAB37082.
GeneIDi916534.
KEGGiece:Z4116.
ecs:ECs3659.
PATRICi18356797. VBIEscCol44059_3581.

Phylogenomic databases

eggNOGiENOG4105C0A. Bacteria.
COG1454. LUCA.
HOGENOMiHOG000243333.
KOiK00048.
OMAiDIVGLYQ.

Enzyme and pathway databases

UniPathwayiUPA00563.

Family and domain databases

InterProiIPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
IPR013460. Lactal_redase.
[Graphical view]
PfamiPF00465. Fe-ADH. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02638. lactal_redase. 1 hit.
PROSITEiPS00913. ADH_IRON_1. 1 hit.
PS00060. ADH_IRON_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFUCO_ECO57
AccessioniPrimary (citable) accession number: P0A9S2
Secondary accession number(s): P11549
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: November 16, 2011
Last modified: November 2, 2016
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.