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Protein

Lactaldehyde reductase

Gene

fucO

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(R)-propane-1,2-diol + NAD+ = (R)-lactaldehyde + NADH.
(S)-propane-1,2-diol + NAD+ = (S)-lactaldehyde + NADH.

Cofactori

Fe cationBy similarity

Pathwayi: L-fucose degradation

This protein is involved in the pathway L-fucose degradation, which is part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the pathway L-fucose degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38NADBy similarity1
Binding sitei70NADBy similarity1
Binding sitei150NADBy similarity1
Binding sitei161NADBy similarity1
Metal bindingi195IronBy similarity1
Metal bindingi199Iron; via tele nitrogenBy similarity1
Metal bindingi262Iron; via tele nitrogenBy similarity1
Metal bindingi276Iron; via tele nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 98NADBy similarity2
Nucleotide bindingi139 – 143NADBy similarity5
Nucleotide bindingi180 – 184NADBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism, Fucose metabolism
LigandIron, Metal-binding, NAD

Enzyme and pathway databases

UniPathwayiUPA00563

Names & Taxonomyi

Protein namesi
Recommended name:
Lactaldehyde reductase (EC:1.1.1.77)
Alternative name(s):
Propanediol oxidoreductase
Gene namesi
Name:fucO
Ordered Locus Names:Z4116, ECs3659
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878251 – 382Lactaldehyde reductaseAdd BLAST382

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi155864.Z4116

Structurei

3D structure databases

ProteinModelPortaliP0A9S2
SMRiP0A9S2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C0A Bacteria
COG1454 LUCA
HOGENOMiHOG000243333
KOiK00048
OMAiCEPGAVQ

Family and domain databases

InterProiView protein in InterPro
IPR001670 ADH_Fe/gldA
IPR018211 ADH_Fe_CS
IPR013460 Lactal_redase
PfamiView protein in Pfam
PF00465 Fe-ADH, 1 hit
TIGRFAMsiTIGR02638 lactal_redase, 1 hit
PROSITEiView protein in PROSITE
PS00913 ADH_IRON_1, 1 hit
PS00060 ADH_IRON_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0A9S2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANRMILNET AWFGRGAVGA LTDEVKRRGY QKALIVTDKT LVQCGVVAKV
60 70 80 90 100
TDKMDAAGLA WAIYDGVVPN PTITVVKEGL GVFQNSGADY LIAIGGGSPQ
110 120 130 140 150
DTCKAIGIIS NNPEFADVRS LEGLSPTNKP SVPILAIPTT AGTAAEVTIN
160 170 180 190 200
YVITDEEKRR KFVCVDPHDI PQVAFIDADM MDGMPPALKA ATGVDALTHA
210 220 230 240 250
IEGYITRGAW ALTDALHIKA IEIIAGALRG SVAGDKDAGE EMALGQYVAG
260 270 280 290 300
MGFSNVGLGL VHGMAHPLGA FYNTPHGVAN AILLPHVMRY NADFTGEKYR
310 320 330 340 350
DIARVMGVKV EGMSLEEARN AAVEAVFALN RDVGIPPHLR DVGVRKEDIP
360 370 380
ALAQAALDDV CTGGNPREAT LEDIVELYHT AW
Length:382
Mass (Da):40,513
Last modified:November 16, 2011 - v2
Checksum:iE4D927AC8142098B
GO

Sequence cautioni

The sequence AAG57913 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB37082 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG57913.1 Different initiation.
BA000007 Genomic DNA Translation: BAB37082.1 Different initiation.
PIRiC91086
E85931
RefSeqiNP_311686.2, NC_002695.1
WP_000013588.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG57913; AAG57913; Z4116
BAB37082; BAB37082; BAB37082
GeneIDi916534
KEGGiece:Z4116
ecs:ECs3659
PATRICifig|386585.9.peg.3825

Similar proteinsi

Entry informationi

Entry nameiFUCO_ECO57
AccessioniPrimary (citable) accession number: P0A9S2
Secondary accession number(s): P11549
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: November 16, 2011
Last modified: April 25, 2018
This is version 81 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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