Reviewed, UniProtKB/Swiss-Prot P0A9S2 (FUCO_ECO57)

Names and origin

Protein names

Recommended name:
    Lactaldehyde reductase
    EC=1.1.1.77
Alternative name(s):
    Propanediol oxidoreductase

Gene names

Name:	fucO
Ordered Locus Names:	Z4116, ECs3659

Organism

Escherichia coli O157:H7 [Complete proteome] [HAMAP]

Taxonomic identifier

83334 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	383 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(R)-propane-1,2-diol + NAD(+) = (R)-lactaldehyde + NADH. (S)-propane-1,2-diol + NAD(+) = (S)-lactaldehyde + NADH.
Cofactor	Iron Potential.
Pathway	Carbohydrate degradation; L-fucose degradation.
Sequence similarities	Belongs to the iron-containing alcohol dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Fucose metabolism
Ligand	Iron NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW lactaldehyde reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 383	383	Lactaldehyde reductase		PRO_0000087825

Sequences

	Sequence		Length	Mass (Da)
	P0A9S2-1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: F0103FED90CA33F3	FASTA	383	40,645
	10 20 30 40 50 60 MMANRMILNE TAWFGRGAVG ALTDEVKRRG YQKALIVTDK TLVQCGVVAK VTDKMDAAGL 70 80 90 100 110 120 AWAIYDGVVP NPTITVVKEG LGVFQNSGAD YLIAIGGGSP QDTCKAIGII SNNPEFADVR 130 140 150 160 170 180 SLEGLSPTNK PSVPILAIPT TAGTAAEVTI NYVITDEEKR RKFVCVDPHD IPQVAFIDAD 190 200 210 220 230 240 MMDGMPPALK AATGVDALTH AIEGYITRGA WALTDALHIK AIEIIAGALR GSVAGDKDAG 250 260 270 280 290 300 EEMALGQYVA GMGFSNVGLG LVHGMAHPLG AFYNTPHGVA NAILLPHVMR YNADFTGEKY 310 320 330 340 350 360 RDIARVMGVK VEGMSLEEAR NAAVEAVFAL NRDVGIPPHL RDVGVRKEDI PALAQAALDD 370 380 VCTGGNPREA TLEDIVELYH TAW

References

[1]

"Genome sequence of enterohaemorrhagic Escherichia coli O157:H7." Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J., Davis N.W. , Lim A., Dimalanta E.T., Potamousis K., Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A., Blattner F.R. Nature 409:529-533(2001) [PubMed: 11206551] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.

[2]

"Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12." Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T. , Kuhara S., Shiba T., Hattori M., Shinagawa H. DNA Res. 8:11-22(2001) [PubMed: 11258796] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE005174 Genomic DNA. Translation: AAG57913.1. BA000007 Genomic DNA. Translation: BAB37082.1.
PIR	C91086. E85931.
RefSeq	NP_289354.1. NP_311686.1.
3D structure databases
SMR	P0A9S2. Positions 2-383.
ModBase	Search...
Genome annotation databases
GeneID	916534. 958299.
GenomeReviews	Gene locus ECs3659 in contig BA000007_GR. Gene locus Z4116 in contig AE005174_GR.
KEGG	ece:Z4116. ecs:ECs3659.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P0A9S2.
Enzyme and pathway databases
BioCyc	ECOL83334:ECS3659-MON.
Family and domain databases
InterPro	IPR001670. Fe_AlcDHase. IPR013460. Lactal_redase. [Graphical view]
Pfam	PF00465. Fe-ADH. 1 hit. [Graphical view]
TIGRFAMs	TIGR02638. lactal_redase. 1 hit.
PROSITE	PS00913. ADH_IRON_1. 1 hit. PS00060. ADH_IRON_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FUCO_ECO57

Accession

Primary (citable) accession number: P0A9S2
Secondary accession number(s): P11549

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	July 19, 2005
Last modified:	November 4, 2008
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)