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P0A9S2

- FUCO_ECO57

UniProt

P0A9S2 - FUCO_ECO57

Protein

Lactaldehyde reductase

Gene

fucO

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 2 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (R)-propane-1,2-diol + NAD+ = (R)-lactaldehyde + NADH.
    (S)-propane-1,2-diol + NAD+ = (S)-lactaldehyde + NADH.

    Cofactori

    Iron.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381NADBy similarity
    Binding sitei70 – 701NADBy similarity
    Binding sitei150 – 1501NADBy similarity
    Binding sitei161 – 1611NADBy similarity
    Metal bindingi195 – 1951IronBy similarity
    Metal bindingi199 – 1991Iron; via tele nitrogenBy similarity
    Metal bindingi262 – 2621Iron; via tele nitrogenBy similarity
    Metal bindingi276 – 2761Iron; via tele nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi97 – 982NADBy similarity
    Nucleotide bindingi139 – 1435NADBy similarity
    Nucleotide bindingi180 – 1845NADBy similarity

    GO - Molecular functioni

    1. lactaldehyde reductase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. fucose catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Fucose metabolism

    Keywords - Ligandi

    Iron, Metal-binding, NAD

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-3623-MONOMER.
    UniPathwayiUPA00563.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lactaldehyde reductase (EC:1.1.1.77)
    Alternative name(s):
    Propanediol oxidoreductase
    Gene namesi
    Name:fucO
    Ordered Locus Names:Z4116, ECs3659
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 382382Lactaldehyde reductasePRO_0000087825Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi155864.Z4116.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A9S2.
    SMRiP0A9S2. Positions 1-382.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1454.
    HOGENOMiHOG000243333.
    KOiK00048.
    OMAiDIVGLYQ.
    OrthoDBiEOG6TFCQS.

    Family and domain databases

    InterProiIPR001670. ADH_Fe.
    IPR018211. ADH_Fe_CS.
    IPR013460. Lactal_redase.
    [Graphical view]
    PfamiPF00465. Fe-ADH. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02638. lactal_redase. 1 hit.
    PROSITEiPS00913. ADH_IRON_1. 1 hit.
    PS00060. ADH_IRON_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A9S2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANRMILNET AWFGRGAVGA LTDEVKRRGY QKALIVTDKT LVQCGVVAKV    50
    TDKMDAAGLA WAIYDGVVPN PTITVVKEGL GVFQNSGADY LIAIGGGSPQ 100
    DTCKAIGIIS NNPEFADVRS LEGLSPTNKP SVPILAIPTT AGTAAEVTIN 150
    YVITDEEKRR KFVCVDPHDI PQVAFIDADM MDGMPPALKA ATGVDALTHA 200
    IEGYITRGAW ALTDALHIKA IEIIAGALRG SVAGDKDAGE EMALGQYVAG 250
    MGFSNVGLGL VHGMAHPLGA FYNTPHGVAN AILLPHVMRY NADFTGEKYR 300
    DIARVMGVKV EGMSLEEARN AAVEAVFALN RDVGIPPHLR DVGVRKEDIP 350
    ALAQAALDDV CTGGNPREAT LEDIVELYHT AW 382
    Length:382
    Mass (Da):40,513
    Last modified:November 16, 2011 - v2
    Checksum:iE4D927AC8142098B
    GO

    Sequence cautioni

    The sequence AAG57913.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence BAB37082.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG57913.1. Different initiation.
    BA000007 Genomic DNA. Translation: BAB37082.1. Different initiation.
    PIRiC91086.
    E85931.
    RefSeqiNP_289354.1. NC_002655.2.
    NP_311686.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG57913; AAG57913; Z4116.
    BAB37082; BAB37082; BAB37082.
    GeneIDi916534.
    958299.
    KEGGiece:Z4116.
    ecs:ECs3659.
    PATRICi18356797. VBIEscCol44059_3581.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG57913.1 . Different initiation.
    BA000007 Genomic DNA. Translation: BAB37082.1 . Different initiation.
    PIRi C91086.
    E85931.
    RefSeqi NP_289354.1. NC_002655.2.
    NP_311686.1. NC_002695.1.

    3D structure databases

    ProteinModelPortali P0A9S2.
    SMRi P0A9S2. Positions 1-382.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 155864.Z4116.

    Protocols and materials databases

    DNASUi 958299.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG57913 ; AAG57913 ; Z4116 .
    BAB37082 ; BAB37082 ; BAB37082 .
    GeneIDi 916534.
    958299.
    KEGGi ece:Z4116.
    ecs:ECs3659.
    PATRICi 18356797. VBIEscCol44059_3581.

    Phylogenomic databases

    eggNOGi COG1454.
    HOGENOMi HOG000243333.
    KOi K00048.
    OMAi DIVGLYQ.
    OrthoDBi EOG6TFCQS.

    Enzyme and pathway databases

    UniPathwayi UPA00563 .
    BioCyci ECOL386585:GJFA-3623-MONOMER.

    Family and domain databases

    InterProi IPR001670. ADH_Fe.
    IPR018211. ADH_Fe_CS.
    IPR013460. Lactal_redase.
    [Graphical view ]
    Pfami PF00465. Fe-ADH. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02638. lactal_redase. 1 hit.
    PROSITEi PS00913. ADH_IRON_1. 1 hit.
    PS00060. ADH_IRON_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiFUCO_ECO57
    AccessioniPrimary (citable) accession number: P0A9S2
    Secondary accession number(s): P11549
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 60 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3