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Protein

Cell division ATP-binding protein FtsE

Gene

ftsE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi35 – 428ATP1 Publication

GO - Molecular functioni

  • ATPase activity Source: InterPro
  • ATP binding Source: EcoliWiki

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: EcoliWiki
  • response to antibiotic Source: EcoliWiki
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:FTSE-MONOMER.
ECOL316407:JW3428-MONOMER.

Protein family/group databases

TCDBi3.A.1.140.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division ATP-binding protein FtsECurated
Gene namesi
Name:ftsE
Ordered Locus Names:b3463, JW3428
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10340. ftsE.

Subcellular locationi

GO - Cellular componenti

  • cell division site Source: EcoliWiki
  • cytoplasm Source: EcoliWiki
  • extrinsic component of cytoplasmic side of plasma membrane Source: EcoCyc
  • extrinsic component of membrane Source: EcoliWiki
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Inactivation results in a filamented cellular morphology, but not in a temperature-sensitive phenotype.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi41 – 411K → R: Does not bind ATP. 1 Publication
Mutagenesisi49 – 491C → A: Prevents dimer formation. Does not alter ATP-binding. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Cell division ATP-binding protein FtsEPRO_0000092328Add
BLAST

Proteomic databases

EPDiP0A9R7.
PaxDbiP0A9R7.

Interactioni

Subunit structurei

Homodimer (PubMed:10048040). Forms a membrane-associated complex with FtsX (PubMed:10048040). Interacts with FtsZ, independently of FtsX, FtsA or ZipA (PubMed:17307852).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ftsZP0A9A62EBI-550637,EBI-370963

Protein-protein interaction databases

BioGridi4260774. 363 interactions.
DIPiDIP-47843N.
IntActiP0A9R7. 27 interactions.
MINTiMINT-1233007.
STRINGi511145.b3463.

Structurei

3D structure databases

ProteinModelPortaliP0A9R7.
SMRiP0A9R7. Positions 1-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 222221ABC transporterPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105CAK. Bacteria.
COG2884. LUCA.
InParanoidiP0A9R7.
KOiK09812.
OMAiYTHKEIR.
PhylomeDBiP0A9R7.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR005286. Cell_div_FtsE_ATP-bd.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02673. FtsE. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A9R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRFEHVSKA YLGGRQALQG VTFHMQPGEM AFLTGHSGAG KSTLLKLICG
60 70 80 90 100
IERPSAGKIW FSGHDITRLK NREVPFLRRQ IGMIFQDHHL LMDRTVYDNV
110 120 130 140 150
AIPLIIAGAS GDDIRRRVSA ALDKVGLLDK AKNFPIQLSG GEQQRVGIAR
160 170 180 190 200
AVVNKPAVLL ADEPTGNLDD ALSEGILRLF EEFNRVGVTV LMATHDINLI
210 220
SRRSYRMLTL SDGHLHGGVG HE
Length:222
Mass (Da):24,439
Last modified:July 19, 2005 - v1
Checksum:i13CFCDECD8FE7590
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04398 Genomic DNA. Translation: CAA27985.1.
U00039 Genomic DNA. Translation: AAB18438.1.
U00096 Genomic DNA. Translation: AAC76488.1.
AP009048 Genomic DNA. Translation: BAE77830.1.
PIRiS03131. CEECFE.
RefSeqiNP_417920.1. NC_000913.3.
WP_000617723.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76488; AAC76488; b3463.
BAE77830; BAE77830; BAE77830.
GeneIDi947968.
KEGGiecj:JW3428.
eco:b3463.
PATRICi32122370. VBIEscCol129921_3562.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04398 Genomic DNA. Translation: CAA27985.1.
U00039 Genomic DNA. Translation: AAB18438.1.
U00096 Genomic DNA. Translation: AAC76488.1.
AP009048 Genomic DNA. Translation: BAE77830.1.
PIRiS03131. CEECFE.
RefSeqiNP_417920.1. NC_000913.3.
WP_000617723.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0A9R7.
SMRiP0A9R7. Positions 1-215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260774. 363 interactions.
DIPiDIP-47843N.
IntActiP0A9R7. 27 interactions.
MINTiMINT-1233007.
STRINGi511145.b3463.

Protein family/group databases

TCDBi3.A.1.140.1. the atp-binding cassette (abc) superfamily.

Proteomic databases

EPDiP0A9R7.
PaxDbiP0A9R7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76488; AAC76488; b3463.
BAE77830; BAE77830; BAE77830.
GeneIDi947968.
KEGGiecj:JW3428.
eco:b3463.
PATRICi32122370. VBIEscCol129921_3562.

Organism-specific databases

EchoBASEiEB0336.
EcoGeneiEG10340. ftsE.

Phylogenomic databases

eggNOGiENOG4105CAK. Bacteria.
COG2884. LUCA.
InParanoidiP0A9R7.
KOiK09812.
OMAiYTHKEIR.
PhylomeDBiP0A9R7.

Enzyme and pathway databases

BioCyciEcoCyc:FTSE-MONOMER.
ECOL316407:JW3428-MONOMER.

Miscellaneous databases

PROiP0A9R7.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR005286. Cell_div_FtsE_ATP-bd.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02673. FtsE. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTSE_ECOLI
AccessioniPrimary (citable) accession number: P0A9R7
Secondary accession number(s): P10115, Q2M7C6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: September 7, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.