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Protein

Aerobic respiration control protein ArcA

Gene

arcA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. Controls the resistance of E.coli to dyes; required for expression of the alkaline phosphatase and sex factor F genes; It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expression of genes of aerobic function. Activates the transcription of the plfB operon by binding to its promoter.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi134 – 234101OmpR/PhoB-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • phosphorelay response regulator activity Source: EcoCyc
  • transcription factor activity, sequence-specific DNA binding Source: EcoCyc

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • phosphorelay signal transduction system Source: EcoCyc
  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:ARCA-MONOMER.
ECOL316407:JW4364-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aerobic respiration control protein ArcA
Alternative name(s):
Dye resistance protein
Gene namesi
Name:arcA
Synonyms:cpxC, dye, fexA, msp, seg, sfrA
Ordered Locus Names:b4401, JW4364
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10061. arcA.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Aerobic respiration control protein ArcAPRO_0000081008Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 5414-aspartylphosphatePROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated by ArcB.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP0A9Q1.
PaxDbiP0A9Q1.
PRIDEiP0A9Q1.

2D gel databases

SWISS-2DPAGEP0A9Q1.

Expressioni

Gene expression databases

CollecTFiEXPREG_00000800.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1119939,EBI-1119939
mexBP520022EBI-1119939,EBI-6400435From a different organism.

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi4259386. 13 interactions.
DIPiDIP-36035N.
IntActiP0A9Q1. 7 interactions.
STRINGi511145.b4401.

Structurei

Secondary structure

1
238
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 95Combined sources
Helixi13 – 2412Combined sources
Turni25 – 273Combined sources
Beta strandi29 – 357Combined sources
Helixi36 – 4510Combined sources
Beta strandi49 – 535Combined sources
Beta strandi58 – 603Combined sources
Helixi62 – 7211Combined sources
Beta strandi76 – 827Combined sources
Helixi86 – 9510Combined sources
Beta strandi98 – 1047Combined sources
Helixi107 – 12115Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XHEX-ray2.50A/B1-123[»]
1XHFX-ray2.15A/B1-123[»]
ProteinModelPortaliP0A9Q1.
SMRiP0A9Q1. Positions 1-234.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A9Q1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 118114Response regulatoryPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 OmpR/PhoB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG41065U4. Bacteria.
COG0745. LUCA.
HOGENOMiHOG000034819.
InParanoidiP0A9Q1.
KOiK07773.
OMAiFLECEGF.
PhylomeDBiP0A9Q1.

Family and domain databases

CDDicd00383. trans_reg_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. OmpR/PhoB-type_DNA-bd.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A9Q1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTPHILIVE DELVTRNTLK SIFEAEGYDV FEATDGAEMH QILSEYDINL
60 70 80 90 100
VIMDINLPGK NGLLLARELR EQANVALMFL TGRDNEVDKI LGLEIGADDY
110 120 130 140 150
ITKPFNPREL TIRARNLLSR TMNLGTVSEE RRSVESYKFN GWELDINSRS
160 170 180 190 200
LIGPDGEQYK LPRSEFRAML HFCENPGKIQ SRAELLKKMT GRELKPHDRT
210 220 230
VDVTIRRIRK HFESTPDTPE IIATIHGEGY RFCGDLED
Length:238
Mass (Da):27,292
Last modified:July 21, 1986 - v1
Checksum:i9316CF4DE8EABDE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10044 Genomic DNA. Translation: AAA23718.1.
U14003 Genomic DNA. Translation: AAA97297.1.
U00096 Genomic DNA. Translation: AAC77354.1.
AP009048 Genomic DNA. Translation: BAE78390.1.
L34010 Genomic DNA. Translation: AAA23476.1.
PIRiA03561. JYECR.
RefSeqiNP_418818.1. NC_000913.3.
WP_001194358.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77354; AAC77354; b4401.
BAE78390; BAE78390; BAE78390.
GeneIDi948874.
KEGGiecj:JW4364.
eco:b4401.
PATRICi32124420. VBIEscCol129921_4550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10044 Genomic DNA. Translation: AAA23718.1.
U14003 Genomic DNA. Translation: AAA97297.1.
U00096 Genomic DNA. Translation: AAC77354.1.
AP009048 Genomic DNA. Translation: BAE78390.1.
L34010 Genomic DNA. Translation: AAA23476.1.
PIRiA03561. JYECR.
RefSeqiNP_418818.1. NC_000913.3.
WP_001194358.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XHEX-ray2.50A/B1-123[»]
1XHFX-ray2.15A/B1-123[»]
ProteinModelPortaliP0A9Q1.
SMRiP0A9Q1. Positions 1-234.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259386. 13 interactions.
DIPiDIP-36035N.
IntActiP0A9Q1. 7 interactions.
STRINGi511145.b4401.

2D gel databases

SWISS-2DPAGEP0A9Q1.

Proteomic databases

EPDiP0A9Q1.
PaxDbiP0A9Q1.
PRIDEiP0A9Q1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77354; AAC77354; b4401.
BAE78390; BAE78390; BAE78390.
GeneIDi948874.
KEGGiecj:JW4364.
eco:b4401.
PATRICi32124420. VBIEscCol129921_4550.

Organism-specific databases

EchoBASEiEB0059.
EcoGeneiEG10061. arcA.

Phylogenomic databases

eggNOGiENOG41065U4. Bacteria.
COG0745. LUCA.
HOGENOMiHOG000034819.
InParanoidiP0A9Q1.
KOiK07773.
OMAiFLECEGF.
PhylomeDBiP0A9Q1.

Enzyme and pathway databases

BioCyciEcoCyc:ARCA-MONOMER.
ECOL316407:JW4364-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0A9Q1.
PROiP0A9Q1.

Gene expression databases

CollecTFiEXPREG_00000800.

Family and domain databases

CDDicd00383. trans_reg_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. OmpR/PhoB-type_DNA-bd.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARCA_ECOLI
AccessioniPrimary (citable) accession number: P0A9Q1
Secondary accession number(s): P03026, Q2M5R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.