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P0A9M9

- PTA_SHIFL

UniProt

P0A9M9 - PTA_SHIFL

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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Shigella flexneri
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in acetate metabolism.By similarity

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathwayi

GO - Molecular functioni

  1. phosphate acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00340; UER00459.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:SF2373, S2508
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000001006: Chromosome, UP000002673: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 714713Phosphate acetyltransferasePRO_0000179139Add
BLAST

Proteomic databases

PaxDbiP0A9M9.
PRIDEiP0A9M9.

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi198214.SF2373.

Structurei

3D structure databases

ProteinModelPortaliP0A9M9.
SMRiP0A9M9. Positions 403-710.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni391 – 714324Phosphate acetyltransferaseAdd
BLAST

Domaini

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site By similarity.By similarity

Sequence similaritiesi

In the N-terminal section; belongs to the CobB/CobQ family.Curated
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.Curated

Phylogenomic databases

eggNOGiCOG0280.
HOGENOMiHOG000053797.
KOiK13788.
OMAiKPIAQPH.
OrthoDBiEOG6BKJ5W.

Family and domain databases

Gene3Di3.40.1390.20. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR027417. P-loop_NTPase.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
IPR028979. Ser_kin/Pase_Hpr_N_like.
[Graphical view]
PfamiPF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF75138. SSF75138. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A9M9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRIIMLIPT GTSVGLTSVS LGVIRAMERK GVRLSVFKPI AQPRTGGDAP
60 70 80 90 100
DQTTTIVRAN SSTTTAAEPL KMSYVEGLLS SNQKDVLMEE IVANYHANTK
110 120 130 140 150
DAEVVLVEGL VPTRKHQFAQ SLNYEIAKTL NAEIVFVMSQ GTDTPEQLKE
160 170 180 190 200
RIELTRNSFG GAKNTNITGV IVNKLNAPVD EQGRTRPDLS EIFDDSSKAK
210 220 230 240 250
VNNVDPAKLQ ESSPLPVLGA VPWSFDLIAT RAIDMARHLN ATIINEGDIN
260 270 280 290 300
TRRVKSVTFC ARSIPHMLEH FRAGSLLVTS ADRPDVLVAA CLAAMNGVEI
310 320 330 340 350
GALLLTGGYE MDARISKLCE RAFATGLPVF MVNTNTWQTS LSLQSFNLEV
360 370 380 390 400
PVDDHERIEK VQEYVANYIN ADWIESLTAT SERSRRLSPP AFRYQLTELA
410 420 430 440 450
RKAGKRIVLP EGDEPRTVKA AAICAERGIA TCVLLGNPAE INRVAASQGV
460 470 480 490 500
ELGAGIEIVD PEVVRESYVG RLVELRKNKG MTETVAREQL EDNVVLGTLM
510 520 530 540 550
LEQDEVDGLV SGAVHTTANT IRPPLQLIKT APGSSLVSSV FFMLLPEQVY
560 570 580 590 600
VYGDCAINPD PTAEQLAEIA IQSADSAAAF GIEPRVAMLS YSTGTSGAGS
610 620 630 640 650
DVEKVREATR LAQEKRPDLM IDGPLQYDAA VMADVAKSKA PNSPVAGRAT
660 670 680 690 700
VFIFPDLNTG NTTYKAVQRS ADLISIGPML QGMRKPVNDL SRGALVDDIV
710
YTIALTAIQS AQQQ
Length:714
Mass (Da):77,172
Last modified:January 23, 2007 - v2
Checksum:iB45AF0C93494A04C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005674 Genomic DNA. Translation: AAN43886.1.
AE014073 Genomic DNA. Translation: AAP17704.1.
RefSeqiNP_708179.1. NC_004337.2.
NP_837894.1. NC_004741.1.

Genome annotation databases

EnsemblBacteriaiAAN43886; AAN43886; SF2373.
AAP17704; AAP17704; S2508.
GeneIDi1027244.
1078796.
KEGGisfl:SF2373.
sfx:S2508.
PATRICi18706611. VBIShiFle31049_2781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005674 Genomic DNA. Translation: AAN43886.1 .
AE014073 Genomic DNA. Translation: AAP17704.1 .
RefSeqi NP_708179.1. NC_004337.2.
NP_837894.1. NC_004741.1.

3D structure databases

ProteinModelPortali P0A9M9.
SMRi P0A9M9. Positions 403-710.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198214.SF2373.

Proteomic databases

PaxDbi P0A9M9.
PRIDEi P0A9M9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN43886 ; AAN43886 ; SF2373 .
AAP17704 ; AAP17704 ; S2508 .
GeneIDi 1027244.
1078796.
KEGGi sfl:SF2373.
sfx:S2508.
PATRICi 18706611. VBIShiFle31049_2781.

Phylogenomic databases

eggNOGi COG0280.
HOGENOMi HOG000053797.
KOi K13788.
OMAi KPIAQPH.
OrthoDBi EOG6BKJ5W.

Enzyme and pathway databases

UniPathwayi UPA00340 ; UER00459 .

Family and domain databases

Gene3Di 3.40.1390.20. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR027417. P-loop_NTPase.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
IPR028979. Ser_kin/Pase_Hpr_N_like.
[Graphical view ]
Pfami PF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view ]
PIRSFi PIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF75138. SSF75138. 1 hit.
TIGRFAMsi TIGR00651. pta. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
    Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
    , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
    Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 301 / Serotype 2a.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700930 / 2457T / Serotype 2a.

Entry informationi

Entry nameiPTA_SHIFL
AccessioniPrimary (citable) accession number: P0A9M9
Secondary accession number(s): P39184
, P78091, P78189, P78190, Q9EUP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3