Reviewed,
UniProtKB/Swiss-Prot P0A9L8 (P5CR_ECOLI)
Last modified
November 25, 2008.
Version 34.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Pyrroline-5-carboxylate reductase Short name=P5C reductase Short name=P5CR EC=1.5.1.2 | ||||
| Gene names |
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| Organism | Escherichia coli (strain K12) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 83333 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 269 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H. |
| Pathway | |
| Subcellular location | |
| Sequence similarities | Belongs to the pyrroline-5-carboxylate reductase family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Proline biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Direct protein sequencing |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic processInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | binding Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 269 | 269 | Pyrroline-5-carboxylate reductase | PRO_0000187289 | |||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| J01665 Genomic DNA. Translation: AAA86433.1. U73857 Genomic DNA. Translation: AAB18110.1. U00096 Genomic DNA. Translation: AAC73489.1. AP009048 Genomic DNA. Translation: BAE76167.1. | |
| PIR | RDECC. A00385. |
| RefSeq | AP_001037.1. NP_414920.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 945034. |
| GenomeReviews | Gene locus b0386 in contig U00096_GR. Gene locus JW0377 in contig AP009048_GR. |
| KEGG | ecj:JW0377. eco:b0386. |
Organism-specific databases | |
| EchoBASE | EB0762. |
| EcoGene | EG10769. proC. |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P0A9L8. |
Enzyme and pathway databases | |
| BioCyc | EcoCyc:PYRROLINECARBREDUCT-MON. MetaCyc:PYRROLINECARBREDUCT-MON. |
Family and domain databases | |
| InterPro | IPR016040. NAD(P)-bd. IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR11645. P5CR. 1 hit. |
| Pfam | PF03807. F420_oxidored. 1 hit. [Graphical view] |
| PIRSF | PIRSF000193. Pyrrol-5-carb_rd. 1 hit. |
| TIGRFAMs | TIGR00112. proC. 1 hit. |
| PROSITE | PS00521. P5CR. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| LinkHub | P0A9L8. |
Entry information
| Entry name | P5CR_ECOLI | ||||||||
| Accession | Primary (citable) accession number: P0A9L8 Secondary accession number(s): P00373, Q2MC39 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Escherichia coli Escherichia coli (strain K12): entries and cross-references to EcoGene |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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