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P0A9L5 (PPIC_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidyl-prolyl cis-trans isomerase C

Short name=PPIase C
EC=5.2.1.8
Alternative name(s):
Par10
Parvulin
Rotamase C
Gene names
Name:ppiC
Synonyms:parVA
Ordered Locus Names:b3775, JW3748
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length93 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

PPIases accelerate the folding of proteins. It prefers amino acid residues with hydrophobic side chains like leucine and phenylalanine in the P1 position of the peptides substrates.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the PpiC/parvulin rotamase family.

Contains 1 PpiC domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1 Ref.5
Chain2 – 9392Peptidyl-prolyl cis-trans isomerase C
PRO_0000193415

Regions

Domain2 – 9190PpiC

Secondary structure

.................... 93
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0A9L5 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 678A1BF2CBEA969B

FASTA9310,232
        10         20         30         40         50         60 
MAKTAAALHI LVKEEKLALD LLEQIKNGAD FGKLAKKHSI CPSGKRGGDL GEFRQGQMVP 

        70         80         90 
AFDKVVFSCP VLEPTGPLHT QFGYHIIKVL YRN 

« Hide

References

« Hide 'large scale' references
[1]"Confirmation of the existence of a third family among peptidyl-prolyl cis/trans isomerases. Amino acid sequence and recombinant production of parvulin."
Rahfeld J.-U., Ruecknagel K.P., Schelbert B., Ludwig B., Hacker J., Mann K., Fischer G.
FEBS Lett. 352:180-184(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-93.
[2]"Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes."
Daniels D.L., Plunkett G. III, Burland V.D., Blattner F.R.
Science 257:771-778(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], SEQUENCE REVISION.
Strain: K12 / MG1655 / ATCC 47076.
[4]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]"A novel peptidyl-prolyl cis/trans isomerase from Escherichia coli."
Rahfeld J.-U., Schierhorn A., Mann K., Fischer G.
FEBS Lett. 343:65-69(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-22, CHARACTERIZATION.
[6]"Conserved sequence motifs in bacterial and bacteriophage chaperonins."
Rudd K.E., Sofia H.J., Koonin E.V., Plunkett G. III, Lazar S., Rouviere P.E.
Trends Biochem. Sci. 20:14-15(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[7]"Solution structure of Escherichia coli Par10: the prototypic member of the parvulin family of peptidyl-prolyl cis/trans isomerases."
Kuhlewein A., Voll G., Hernandez Alvarez B., Kessler H., Fischer G., Rahfeld J.-U., Gemmecker G.
Protein Sci. 13:2378-2387(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S73874 Genomic DNA. Translation: AAB32054.1.
M87049 Genomic DNA. Translation: AAA67578.1.
U00096 Genomic DNA. Translation: AAC76780.1.
AP009048 Genomic DNA. Translation: BAE77522.1.
PIRS48658.
RefSeqNP_418223.1. NC_000913.3.
YP_491663.1. NC_007779.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1JNSNMR-A2-93[»]
1JNTNMR-A2-93[»]
ProteinModelPortalP0A9L5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-48081N.
IntActP0A9L5. 13 interactions.
MINTMINT-1225694.
STRING511145.b3775.

Proteomic databases

PaxDbP0A9L5.
PRIDEP0A9L5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC76780; AAC76780; b3775.
BAE77522; BAE77522; BAE77522.
GeneID12934320.
948285.
KEGGecj:Y75_p3400.
eco:b3775.
PATRIC32123045. VBIEscCol129921_3892.

Organism-specific databases

EchoBASEEB2256.
EcoGeneEG12352. ppiC.

Phylogenomic databases

eggNOGCOG0760.
HOGENOMHOG000275329.
KOK03769.
OMASCELLKP.
OrthoDBEOG690MCF.
PhylomeDBP0A9L5.

Enzyme and pathway databases

BioCycEcoCyc:EG12352-MONOMER.
ECOL316407:JW3748-MONOMER.
MetaCyc:EG12352-MONOMER.

Gene expression databases

GenevestigatorP0A9L5.

Family and domain databases

InterProIPR000297. PPIase_PpiC.
IPR023058. PPIase_PpiC_CS.
[Graphical view]
PfamPF00639. Rotamase. 1 hit.
[Graphical view]
PROSITEPS01096. PPIC_PPIASE_1. 1 hit.
PS50198. PPIC_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP0A9L5.
PROP0A9L5.

Entry information

Entry namePPIC_ECOLI
AccessionPrimary (citable) accession number: P0A9L5
Secondary accession number(s): P39159, Q2M884
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene