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P0A9J5

- PANE_SHIFL

UniProt

P0A9J5 - PANE_SHIFL

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Protein
2-dehydropantoate 2-reductase
Gene
panE, apbA, SF0362, S0370
Organism
Shigella flexneri
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid By similarity.

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311NADP; via amide nitrogen By similarity
Binding sitei98 – 981NADP; via amide nitrogen By similarity
Binding sitei98 – 981Substrate By similarity
Binding sitei122 – 1221NADP; via amide nitrogen and carbonyl oxygen By similarity
Active sitei176 – 1761Proton donor By similarity
Binding sitei180 – 1801Substrate By similarity
Binding sitei184 – 1841Substrate By similarity
Binding sitei194 – 1941Substrate By similarity
Binding sitei241 – 2411Substrate By similarity
Binding sitei244 – 2441Substrate By similarity
Binding sitei256 – 2561NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 126NADP By similarity

GO - Molecular functioni

  1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00028; UER00004.

Names & Taxonomyi

Protein namesi
Recommended name:
2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Name:panE
Synonyms:apbA
Ordered Locus Names:SF0362, S0370
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000001006: Chromosome, UP000002673: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3033032-dehydropantoate 2-reductase
PRO_0000157305Add
BLAST

Proteomic databases

PaxDbiP0A9J5.

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi198214.SF0362.

Structurei

3D structure databases

ProteinModelPortaliP0A9J5.
SMRiP0A9J5. Positions 1-292.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000050223.
KOiK00077.
OMAiSQCHILL.
OrthoDBiEOG68SVW3.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A9J5-1 [UniParc]FASTAAdd to Basket

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MKITVLGCGA LGQLWLTALC KQGHEVQGWL RVPQPYCSVN LVETDGSIFN    50
ESLTANDPDF LATSDLLLVT LKAWQVSDAV KSLASTLPVT TPILLIHNGM 100
GTIEELQNIQ QPLLMGTTTH AARRDGNVII HVANGITHIG PARQQDGDYS 150
YLADILQTVL PDVAWHNNIR AELWRKLAVN CVINPLTAIW NCPNGELRHH 200
PQEIMQICEE VAAVIEREGH HTSAEDLRDY VMQVIDATAE NISSMLQDIR 250
ALRHTEIDYI NGFLLRRARA HGIAVPENTR LFEMVKRKES EYERIGTGLP 300
RPW 303
Length:303
Mass (Da):33,871
Last modified:July 19, 2005 - v1
Checksum:iED7027BFE6F86D6F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005674 Genomic DNA. Translation: AAN42020.1.
AE014073 Genomic DNA. Translation: AAP15896.1.
RefSeqiNP_706313.1. NC_004337.2.
NP_836090.1. NC_004741.1.

Genome annotation databases

EnsemblBacteriaiAAN42020; AAN42020; SF0362.
AAP15896; AAP15896; S0370.
GeneIDi1027702.
1076803.
KEGGisfl:SF0362.
sfx:S0370.
PATRICi18701740. VBIShiFle31049_0403.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005674 Genomic DNA. Translation: AAN42020.1 .
AE014073 Genomic DNA. Translation: AAP15896.1 .
RefSeqi NP_706313.1. NC_004337.2.
NP_836090.1. NC_004741.1.

3D structure databases

ProteinModelPortali P0A9J5.
SMRi P0A9J5. Positions 1-292.
ModBasei Search...

Protein-protein interaction databases

STRINGi 198214.SF0362.

Chemistry

BindingDBi P0A9J5.

Proteomic databases

PaxDbi P0A9J5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN42020 ; AAN42020 ; SF0362 .
AAP15896 ; AAP15896 ; S0370 .
GeneIDi 1027702.
1076803.
KEGGi sfl:SF0362.
sfx:S0370.
PATRICi 18701740. VBIShiFle31049_0403.

Phylogenomic databases

eggNOGi COG1893.
HOGENOMi HOG000050223.
KOi K00077.
OMAi SQCHILL.
OrthoDBi EOG68SVW3.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00004 .

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
    Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
    , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
    Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 301 / Serotype 2a.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700930 / 2457T / Serotype 2a.

Entry informationi

Entry nameiPANE_SHIFL
AccessioniPrimary (citable) accession number: P0A9J5
Secondary accession number(s): P77728, Q46947
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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