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Protein

Glycine cleavage system transcriptional repressor

Gene

gcvR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how GcvR acts as a repressor. It does not seem to bind DNA. It could interact with GcvA and suppress its activatory activity.

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: EcoCyc

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG11149-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine cleavage system transcriptional repressor
Alternative name(s):
gcv operon repressor
Gene namesi
Name:gcvR
Synonyms:yffD
Ordered Locus Names:b2479, JW2464
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11149 gcvR

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000874482 – 190Glycine cleavage system transcriptional repressorAdd BLAST189

Proteomic databases

EPDiP0A9I3
PaxDbiP0A9I3
PRIDEiP0A9I3

Interactioni

Protein-protein interaction databases

BioGridi42605808 interactors.
DIPiDIP-9754N
IntActiP0A9I3 3 interactors.
STRINGi316385.ECDH10B_2645

Structurei

3D structure databases

ProteinModelPortaliP0A9I3
SMRiP0A9I3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 91ACT 1PROSITE-ProRule annotationAdd BLAST82
Domaini97 – 176ACT 2PROSITE-ProRule annotationAdd BLAST80

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105RH4 Bacteria
COG2716 LUCA
HOGENOMiHOG000272598
InParanoidiP0A9I3
KOiK03567
OMAiQTGGTML
PhylomeDBiP0A9I3

Family and domain databases

InterProiView protein in InterPro
IPR002912 ACT_dom
IPR016867 GcvR
PfamiView protein in Pfam
PF01842 ACT, 1 hit
PIRSFiPIRSF028103 GcvR, 1 hit
PROSITEiView protein in PROSITE
PS51671 ACT, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A9I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLSSQHYLV ITALGADRPG IVNTITRHVS SCGCNIEDSR LAMLGEEFTF
60 70 80 90 100
IMLLSGSWNA ITLIESTLPL KGAELDLLIV MKRTTARPRP PMPASVWVQV
110 120 130 140 150
DVADSPHLIE RFTALFDAHH MNIAELVSRT QPAENERAAQ LHIQITAHSP
160 170 180 190
ASADAANIEQ AFKALCTELN AQGSINVVNY SQHDEQDGVK
Length:190
Mass (Da):20,769
Last modified:January 23, 2007 - v2
Checksum:i66A1998E767B556B
GO

Sequence cautioni

The sequence AAB88561 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023337 Genomic DNA Translation: AAC46232.1
U00096 Genomic DNA Translation: AAC75532.2
AP009048 Genomic DNA Translation: BAA16356.2
M63654 Genomic DNA Translation: AAB88561.1 Different initiation.
RefSeqiNP_416974.4, NC_000913.3
WP_000176187.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75532; AAC75532; b2479
BAA16356; BAA16356; BAA16356
GeneIDi946950
KEGGiecj:JW2464
eco:b2479
PATRICifig|1411691.4.peg.4260

Similar proteinsi

Entry informationi

Entry nameiGCVR_ECOLI
AccessioniPrimary (citable) accession number: P0A9I3
Secondary accession number(s): O30979, P23483, P77652
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome