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P0A9H8

- CFA_ECOL6

UniProt

P0A9H8 - CFA_ECOL6

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Protein

Cyclopropane-fatty-acyl-phospholipid synthase

Gene
cfa, c2055
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Transfers a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge By similarity.

Catalytic activityi

S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei354 – 3541 By similarity

GO - Molecular functioni

  1. cyclopropane-fatty-acyl-phospholipid synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciECOL199310:C2055-MONOMER.
SABIO-RKP0A9H8.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclopropane-fatty-acyl-phospholipid synthase (EC:2.1.1.79)
Short name:
CFA synthase
Short name:
Cyclopropane fatty acid synthase
Gene namesi
Name:cfa
Ordered Locus Names:c2055
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001410: Chromosome

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 382381Cyclopropane-fatty-acyl-phospholipid synthasePRO_0000089571Add
BLAST

Proteomic databases

PRIDEiP0A9H8.

Interactioni

Protein-protein interaction databases

STRINGi199310.c2055.

Structurei

3D structure databases

ProteinModelPortaliP0A9H8.
SMRiP0A9H8. Positions 120-359.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni137 – 1382S-adenosyl-L-methionine binding By similarity
Regioni171 – 1799S-adenosyl-L-methionine binding By similarity
Regioni197 – 2026S-adenosyl-L-methionine binding By similarity

Sequence similaritiesi

Belongs to the CFA/CMAS family.

Phylogenomic databases

HOGENOMiHOG000245194.
KOiK00574.
OMAiLMLDPYM.
OrthoDBiEOG6BGNZP.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR003333. Mycolic_cyclopropane_synthase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF02353. CMAS. 1 hit.
[Graphical view]
PIRSFiPIRSF003085. CMAS. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A9H8-1 [UniParc]FASTAAdd to Basket

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MSSSCIEEVS VPDDNWYRIA NELLSRAGIA INGSAPADIR VKNPDFFKRV    50
LQEGSLGLGE SYMDGWWECD RLDMFFSKVL RAGLENQLPH HFKDTLRIAG 100
ARLFNLQSKK RAWIVGKEHY DLGNDLFSRM LDPFMQYSCA YWKDADNLES 150
AQQAKLKMIC EKLQLKPGMR VLDIGCGWGG LAHYMASNYD VSVVGVTISA 200
EQQKMAQERC EGLDVTILLQ DYRDLNDQFD RIVSVGMFEH VGPKNYDTYF 250
AVVDRNLKPE GIFLLHTIGS KKTDLNVDPW INKYIFPNGC LPSVRQIAQS 300
SEPHFVMEDW HNFGADYDTT LMAWYERFLA AWPEIADNYS ERFKRMFTYY 350
LNACAGAFRA RDIQLWQVVF SRGVENGLRV AR 382
Length:382
Mass (Da):43,909
Last modified:January 23, 2007 - v2
Checksum:i861FF3314FDAF2C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN80515.1.
RefSeqiNP_753950.1. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN80515; AAN80515; c2055.
GeneIDi1036202.
KEGGiecc:c2055.
PATRICi18282011. VBIEscCol75197_1924.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN80515.1 .
RefSeqi NP_753950.1. NC_004431.1.

3D structure databases

ProteinModelPortali P0A9H8.
SMRi P0A9H8. Positions 120-359.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 199310.c2055.

Proteomic databases

PRIDEi P0A9H8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN80515 ; AAN80515 ; c2055 .
GeneIDi 1036202.
KEGGi ecc:c2055.
PATRICi 18282011. VBIEscCol75197_1924.

Phylogenomic databases

HOGENOMi HOG000245194.
KOi K00574.
OMAi LMLDPYM.
OrthoDBi EOG6BGNZP.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci ECOL199310:C2055-MONOMER.
SABIO-RK P0A9H8.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR003333. Mycolic_cyclopropane_synthase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF02353. CMAS. 1 hit.
[Graphical view ]
PIRSFi PIRSF003085. CMAS. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFT073 / ATCC 700928 / UPEC.

Entry informationi

Entry nameiCFA_ECOL6
AccessioniPrimary (citable) accession number: P0A9H8
Secondary accession number(s): P30010
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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