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P0A9H8

- CFA_ECOL6

UniProt

P0A9H8 - CFA_ECOL6

Protein

Cyclopropane-fatty-acyl-phospholipid synthase

Gene

cfa

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Transfers a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei354 – 3541By similarity

    GO - Molecular functioni

    1. cyclopropane-fatty-acyl-phospholipid synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciECOL199310:C2055-MONOMER.
    SABIO-RKP0A9H8.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclopropane-fatty-acyl-phospholipid synthase (EC:2.1.1.79)
    Short name:
    CFA synthase
    Short name:
    Cyclopropane fatty acid synthase
    Gene namesi
    Name:cfa
    Ordered Locus Names:c2055
    OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
    Taxonomic identifieri199310 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001410: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 382381Cyclopropane-fatty-acyl-phospholipid synthasePRO_0000089571Add
    BLAST

    Proteomic databases

    PRIDEiP0A9H8.

    Interactioni

    Protein-protein interaction databases

    STRINGi199310.c2055.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A9H8.
    SMRiP0A9H8. Positions 120-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni137 – 1382S-adenosyl-L-methionine bindingBy similarity
    Regioni171 – 1799S-adenosyl-L-methionine bindingBy similarity
    Regioni197 – 2026S-adenosyl-L-methionine bindingBy similarity

    Sequence similaritiesi

    Belongs to the CFA/CMAS family.Curated

    Phylogenomic databases

    HOGENOMiHOG000245194.
    KOiK00574.
    OMAiLMLDPYM.
    OrthoDBiEOG6BGNZP.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR003333. Mycolic_cyclopropane_synthase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF02353. CMAS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003085. CMAS. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0A9H8-1 [UniParc]FASTAAdd to Basket

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    MSSSCIEEVS VPDDNWYRIA NELLSRAGIA INGSAPADIR VKNPDFFKRV    50
    LQEGSLGLGE SYMDGWWECD RLDMFFSKVL RAGLENQLPH HFKDTLRIAG 100
    ARLFNLQSKK RAWIVGKEHY DLGNDLFSRM LDPFMQYSCA YWKDADNLES 150
    AQQAKLKMIC EKLQLKPGMR VLDIGCGWGG LAHYMASNYD VSVVGVTISA 200
    EQQKMAQERC EGLDVTILLQ DYRDLNDQFD RIVSVGMFEH VGPKNYDTYF 250
    AVVDRNLKPE GIFLLHTIGS KKTDLNVDPW INKYIFPNGC LPSVRQIAQS 300
    SEPHFVMEDW HNFGADYDTT LMAWYERFLA AWPEIADNYS ERFKRMFTYY 350
    LNACAGAFRA RDIQLWQVVF SRGVENGLRV AR 382
    Length:382
    Mass (Da):43,909
    Last modified:January 23, 2007 - v2
    Checksum:i861FF3314FDAF2C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN80515.1.
    RefSeqiNP_753950.1. NC_004431.1.

    Genome annotation databases

    EnsemblBacteriaiAAN80515; AAN80515; c2055.
    GeneIDi1036202.
    KEGGiecc:c2055.
    PATRICi18282011. VBIEscCol75197_1924.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN80515.1 .
    RefSeqi NP_753950.1. NC_004431.1.

    3D structure databases

    ProteinModelPortali P0A9H8.
    SMRi P0A9H8. Positions 120-359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 199310.c2055.

    Proteomic databases

    PRIDEi P0A9H8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN80515 ; AAN80515 ; c2055 .
    GeneIDi 1036202.
    KEGGi ecc:c2055.
    PATRICi 18282011. VBIEscCol75197_1924.

    Phylogenomic databases

    HOGENOMi HOG000245194.
    KOi K00574.
    OMAi LMLDPYM.
    OrthoDBi EOG6BGNZP.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci ECOL199310:C2055-MONOMER.
    SABIO-RK P0A9H8.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR003333. Mycolic_cyclopropane_synthase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF02353. CMAS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003085. CMAS. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CFT073 / ATCC 700928 / UPEC.

    Entry informationi

    Entry nameiCFA_ECOL6
    AccessioniPrimary (citable) accession number: P0A9H8
    Secondary accession number(s): P30010
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 64 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3