P0A9H6 (BTUR_ECOL6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cob(I)yrinic acid a,c-diamide adenosyltransferase
EC=2.5.1.17

Alternative name(s):
Cob(I)alamin adenosyltransferase
Corrinoid adenosyltransferase

Gene names

Name:	btuR
Ordered Locus Names:	c1735

Organism

Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

199310 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids By similarity.
Catalytic activity	ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide. ATP + cobinamide = triphosphate + adenosylcobinamide.
Pathway	Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the Cob(I)alamin adenosyltransferase family.

Ontologies

Keywords
Biological process	Cobalamin biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cobalamin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cob(I)yrinic acid a,c-diamide adenosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 196	196	Cob(I)yrinic acid a,c-diamide adenosyltransferase		PRO_0000065008
Regions
	Nucleotide binding	36 – 42	7	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0A9H6 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: 4EE2FDD9C74FE8AE	FASTA	196	21,999
	10 20 30 40 50 60 MSDERYQQRQ QRVKEKVDAR VAQAQDERGI IIVFTGNGKG KTTAAFGTAT RAVGHGKKVG 70 80 90 100 110 120 VVQFIKGTWP NGERNLLEPH GVEFQVMATG FTWDTQNRES DTAACREVWQ HAKRMLADSS 130 140 150 160 170 180 LDMVLLDELT YMVAYDYLPL EEVVQALNER PHQQTVIITG RGCHRDILEL ADTVSELRPV 190 KHAFDAGVKA QIGIDY

References

[1]

"Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli." Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T., Donnenberg M.S., Blattner F.R. Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CFT073 / ATCC 700928 / UPEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014075 Genomic DNA. Translation: AAN80201.1.
RefSeq	NP_753639.1. NC_004431.1.
3D structure databases
ProteinModelPortal	P0A9H6.
SMR	P0A9H6. Positions 28-196.
ModBase	Search...
Protein-protein interaction databases
STRING	199310.c1735.
Proteomic databases
PRIDE	P0A9H6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN80201; AAN80201; c1735.
GeneID	1035519.
KEGG	ecc:c1735.
PATRIC	18281392. VBIEscCol75197_1615.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000260311.
KO	K00798.
OMA	WHTMGEG.
ProtClustDB	PRK05986.
Enzyme and pathway databases
UniPathway	UPA00148; UER00233.
Family and domain databases
InterPro	IPR003724. AdoCbl_synth_CblAdoTrfase_CobA. IPR025826. Co_AT_N_dom. [Graphical view]
Pfam	PF12557. Co_AT_N. 1 hit. PF02572. CobA_CobO_BtuR. 1 hit. [Graphical view]
PIRSF	PIRSF015617. Adensltrnsf_CobA. 1 hit.
TIGRFAMs	TIGR00708. cobA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

BTUR_ECOL6

Accession

Primary (citable) accession number: P0A9H6
Secondary accession number(s): P13040

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	July 19, 2005
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program