SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P0A9H6

- BTUR_ECOL6

UniProt

P0A9H6 - BTUR_ECOL6

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cob(I)yrinic acid a,c-diamide adenosyltransferase

Gene
btuR, c1735
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids By similarity.

Catalytic activityi

ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.
ATP + cobinamide = triphosphate + adenosylcobinamide.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 427ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cob(I)yrinic acid a,c-diamide adenosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cobalamin biosynthetic process Source: UniProtKB-UniPathway
  2. porphyrin-containing compound biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cobalamin biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciECOL199310:C1735-MONOMER.
UniPathwayiUPA00148; UER00233.

Names & Taxonomyi

Protein namesi
Recommended name:
Cob(I)yrinic acid a,c-diamide adenosyltransferase (EC:2.5.1.17)
Alternative name(s):
Cob(I)alamin adenosyltransferase
Corrinoid adenosyltransferase
Gene namesi
Name:btuR
Ordered Locus Names:c1735
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001410: Chromosome

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196Cob(I)yrinic acid a,c-diamide adenosyltransferasePRO_0000065008Add
BLAST

Proteomic databases

PRIDEiP0A9H6.

Interactioni

Protein-protein interaction databases

STRINGi199310.c1735.

Structurei

3D structure databases

ProteinModelPortaliP0A9H6.
SMRiP0A9H6. Positions 28-196.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000260311.
KOiK00798.
OMAiKGERRNA.
OrthoDBiEOG6GN76J.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003724. AdoCbl_synth_CblAdoTrfase_CobA.
IPR025826. Co_AT_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF12557. Co_AT_N. 1 hit.
PF02572. CobA_CobO_BtuR. 1 hit.
[Graphical view]
PIRSFiPIRSF015617. Adensltrnsf_CobA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00708. cobA. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A9H6-1 [UniParc]FASTAAdd to Basket

« Hide

MSDERYQQRQ QRVKEKVDAR VAQAQDERGI IIVFTGNGKG KTTAAFGTAT    50
RAVGHGKKVG VVQFIKGTWP NGERNLLEPH GVEFQVMATG FTWDTQNRES 100
DTAACREVWQ HAKRMLADSS LDMVLLDELT YMVAYDYLPL EEVVQALNER 150
PHQQTVIITG RGCHRDILEL ADTVSELRPV KHAFDAGVKA QIGIDY 196
Length:196
Mass (Da):21,999
Last modified:July 19, 2005 - v1
Checksum:i4EE2FDD9C74FE8AE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN80201.1.
RefSeqiNP_753639.1. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN80201; AAN80201; c1735.
GeneIDi1035519.
KEGGiecc:c1735.
PATRICi18281392. VBIEscCol75197_1615.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN80201.1 .
RefSeqi NP_753639.1. NC_004431.1.

3D structure databases

ProteinModelPortali P0A9H6.
SMRi P0A9H6. Positions 28-196.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 199310.c1735.

Proteomic databases

PRIDEi P0A9H6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN80201 ; AAN80201 ; c1735 .
GeneIDi 1035519.
KEGGi ecc:c1735.
PATRICi 18281392. VBIEscCol75197_1615.

Phylogenomic databases

HOGENOMi HOG000260311.
KOi K00798.
OMAi KGERRNA.
OrthoDBi EOG6GN76J.

Enzyme and pathway databases

UniPathwayi UPA00148 ; UER00233 .
BioCyci ECOL199310:C1735-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003724. AdoCbl_synth_CblAdoTrfase_CobA.
IPR025826. Co_AT_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF12557. Co_AT_N. 1 hit.
PF02572. CobA_CobO_BtuR. 1 hit.
[Graphical view ]
PIRSFi PIRSF015617. Adensltrnsf_CobA. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00708. cobA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFT073 / ATCC 700928 / UPEC.

Entry informationi

Entry nameiBTUR_ECOL6
AccessioniPrimary (citable) accession number: P0A9H6
Secondary accession number(s): P13040
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi