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P0A9H6

- BTUR_ECOL6

UniProt

P0A9H6 - BTUR_ECOL6

Protein

Cob(I)yrinic acid a,c-diamide adenosyltransferase

Gene

btuR

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids By similarity.By similarity

    Catalytic activityi

    ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.
    ATP + cobinamide = triphosphate + adenosylcobinamide.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi36 – 427ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cob(I)yrinic acid a,c-diamide adenosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cobalamin biosynthetic process Source: UniProtKB-UniPathway
    2. porphyrin-containing compound biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Cobalamin biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciECOL199310:C1735-MONOMER.
    UniPathwayiUPA00148; UER00233.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cob(I)yrinic acid a,c-diamide adenosyltransferase (EC:2.5.1.17)
    Alternative name(s):
    Cob(I)alamin adenosyltransferase
    Corrinoid adenosyltransferase
    Gene namesi
    Name:btuR
    Ordered Locus Names:c1735
    OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
    Taxonomic identifieri199310 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001410: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 196196Cob(I)yrinic acid a,c-diamide adenosyltransferasePRO_0000065008Add
    BLAST

    Proteomic databases

    PRIDEiP0A9H6.

    Interactioni

    Protein-protein interaction databases

    STRINGi199310.c1735.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A9H6.
    SMRiP0A9H6. Positions 28-196.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000260311.
    KOiK00798.
    OMAiKGERRNA.
    OrthoDBiEOG6GN76J.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003724. AdoCbl_synth_CblAdoTrfase_CobA.
    IPR025826. Co_AT_N_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF12557. Co_AT_N. 1 hit.
    PF02572. CobA_CobO_BtuR. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015617. Adensltrnsf_CobA. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00708. cobA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0A9H6-1 [UniParc]FASTAAdd to Basket

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    MSDERYQQRQ QRVKEKVDAR VAQAQDERGI IIVFTGNGKG KTTAAFGTAT    50
    RAVGHGKKVG VVQFIKGTWP NGERNLLEPH GVEFQVMATG FTWDTQNRES 100
    DTAACREVWQ HAKRMLADSS LDMVLLDELT YMVAYDYLPL EEVVQALNER 150
    PHQQTVIITG RGCHRDILEL ADTVSELRPV KHAFDAGVKA QIGIDY 196
    Length:196
    Mass (Da):21,999
    Last modified:July 19, 2005 - v1
    Checksum:i4EE2FDD9C74FE8AE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN80201.1.
    RefSeqiNP_753639.1. NC_004431.1.

    Genome annotation databases

    EnsemblBacteriaiAAN80201; AAN80201; c1735.
    GeneIDi1035519.
    KEGGiecc:c1735.
    PATRICi18281392. VBIEscCol75197_1615.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN80201.1 .
    RefSeqi NP_753639.1. NC_004431.1.

    3D structure databases

    ProteinModelPortali P0A9H6.
    SMRi P0A9H6. Positions 28-196.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 199310.c1735.

    Proteomic databases

    PRIDEi P0A9H6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN80201 ; AAN80201 ; c1735 .
    GeneIDi 1035519.
    KEGGi ecc:c1735.
    PATRICi 18281392. VBIEscCol75197_1615.

    Phylogenomic databases

    HOGENOMi HOG000260311.
    KOi K00798.
    OMAi KGERRNA.
    OrthoDBi EOG6GN76J.

    Enzyme and pathway databases

    UniPathwayi UPA00148 ; UER00233 .
    BioCyci ECOL199310:C1735-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003724. AdoCbl_synth_CblAdoTrfase_CobA.
    IPR025826. Co_AT_N_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF12557. Co_AT_N. 1 hit.
    PF02572. CobA_CobO_BtuR. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015617. Adensltrnsf_CobA. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00708. cobA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CFT073 / ATCC 700928 / UPEC.

    Entry informationi

    Entry nameiBTUR_ECOL6
    AccessioniPrimary (citable) accession number: P0A9H6
    Secondary accession number(s): P13040
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3